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- Ackermann, M., et al.
(författare)
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Gamma-ray observations of the orion molecular clouds with the fermi large area telescope
- 2012
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 756:1, s. 4-
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Tidskriftsartikel (refereegranskat)abstract
- We report on the gamma-ray observations of giant molecular clouds Orion A and B with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. The gamma-ray emission in the energy band between similar to 100 MeV and similar to 100 GeV is predicted to trace the gas mass distribution in the clouds through nuclear interactions between the Galactic cosmic rays (CRs) and interstellar gas. The gamma-ray production cross-section for the nuclear interaction is known to similar to 10% precision which makes the LAT a powerful tool to measure the gas mass column density distribution of molecular clouds for a known CR intensity. We present here such distributions for Orion A and B, and correlate them with those of the velocity-integrated CO intensity (W-CO) at a 1 degrees x 1 degrees pixel level. The correlation is found to be linear over a W-CO range of similar to 10-fold when divided in three regions, suggesting penetration of nuclear CRs to most of the cloud volumes. The W-CO-to-mass conversion factor, X-CO, is found to be similar to 2.3 x 10(20) cm(-2) (K km s(-1))(-1) for the high-longitude part of Orion A (l > 212 degrees), similar to 1.7 times higher than similar to 1.3 x 10(20) found for the rest of Orion A and B. We interpret the apparent high XCO in the high-longitude region of Orion A in the light of recent works proposing a nonlinear relation between H-2 and CO densities in the diffuse molecular gas. W-CO decreases faster than the H-2 column density in the region making the gas "darker" to W-CO.
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- Ochi, Y, et al.
(författare)
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Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 2833-
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Tidskriftsartikel (refereegranskat)abstract
- Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 BC and 148 chronic phase (CP) samples obtained from 216 CML patients using exome and targeted sequencing. One or more genetic abnormalities are found in 126 (92.6%) out of the 136 BC patients, including the RUNX1-ETS2 fusion and NBEAL2 mutations. The number of genetic alterations increase during the transition from CP to BC, which is markedly suppressed by tyrosine kinase inhibitors (TKIs). The lineage of the BC and prior use of TKIs correlate with distinct molecular profiles. Notably, genetic alterations, rather than clinical variables, contribute to a better prediction of BC prognosis. In conclusion, genetic abnormalities can help predict clinical outcomes and can guide clinical decisions in CML.
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- Margutti, R., et al.
(författare)
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INVERSE COMPTON X-RAY EMISSION FROM SUPERNOVAE WITH COMPACT PROGENITORS : APPLICATION TO SN2011fe
- 2012
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 751:2, s. 134-
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Tidskriftsartikel (refereegranskat)abstract
- We present a generalized analytic formalism for the inverse Compton X-ray emission from hydrogen-poor supernovae and apply this framework to SN 2011fe using Swift X-Ray Telescope (XRT), UVOT, and Chandra observations. We characterize the optical properties of SN 2011fe in the Swift bands and find them to be broadly consistent with a normal SN Ia, however, no X-ray source is detected by either XRT or Chandra. We constrain the progenitor system mass-loss rate (M) over dot < 2 x 10(-9) M-circle dot yr(-1) (3 sigma c.l.) for wind velocity v(w) = 100 km s(-1). Our result rules out symbiotic binary progenitors for SN 2011fe and argues against Roche lobe overflowing subgiants and main-sequence secondary stars if greater than or similar to 1% of the transferred mass is lost at the Lagrangian points. Regardless of the density profile, the X-ray non-detections are suggestive of a clean environment (n(CSM) < 150 cm(-3)) for 2 x 10(15) less than or similar to R less than or similar to 5 x 10(16) cm around the progenitor site. This is either consistent with the bulk of material being confined within the binary system or with a significant delay between mass loss and supernova explosion. We furthermore combine X-ray and radio limits from Chomiuk et al. to constrain the post-shock energy density in magnetic fields. Finally, we searched for the shock breakout pulse using gamma-ray observations from the Interplanetary Network and find no compelling evidence for a supernova-associated burst. Based on the compact radius of the progenitor star we estimate that the shock breakout pulse was likely not detectable by current satellites.
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