| 1. |
- Ovadia, C., et al.
(författare)
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Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
- 2021
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Ingår i: Lancet Gastroenterology & Hepatology. - : Elsevier BV. - 2468-1253. ; 6:7
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Tidskriftsartikel (refereegranskat)abstract
- Background Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet its largest trial detected minimal benefit for a composite outcome (stillbirth, preterm birth, and neonatal unit admission). We aimed to examine whether ursodeoxycholic acid affects specific adverse perinatal outcomes. Methods In this systematic review and individual participant data meta-analysis, we searched PubMed, Web of Science, Embase, MEDLINE, CINAHL, Global Health, MIDIRS, and Cochrane without language restrictions for relevant articles published between database inception, and Jan 1, 2020, using search terms referencing intrahepatic cholestasis of pregnancy, ursodeoxycholic acid, and perinatal outcomes. Eligible studies had 30 or more study participants and reported on at least one individual with intrahepatic cholestasis of pregnancy and bile acid concentrations of 40 mu mol/L or more. We also included two unpublished cohort studies. Individual participant data were collected from the authors of selected studies. The primary outcome was the prevalence of stillbirth, for which we anticipated there would be insufficient data to achieve statistical power. Therefore, we included a composite of stillbirth and preterm birth as a main secondary outcome. A mixed-effects meta-analysis was done using multi-level modelling and adjusting for bile acid concentration, parity, and multifetal pregnancy. Individual participant data analyses were done for all studies and in different subgroups, which were produced by limiting analyses to randomised controlled trials only, singleton pregnancies only, or two-arm studies only. This study is registered with PROSPERO, CRD42019131495. Findings The authors of the 85 studies fulfilling our inclusion criteria were contacted. Individual participant data from 6974 women in 34 studies were included in the meta-analysis, of whom 4726 (67.8%) took ursodeoxycholic acid. Stillbirth occurred in 35 (0.7%) of 5097 fetuses among women with intrahepatic cholestasis of pregnancy treated with ursodeoxycholic acid and in 12 (0.6%) of 2038 fetuses among women with intrahepatic cholestasis of pregnancy not treated with ursodeoxycholic acid (adjusted odds ratio [aOR] 1.04, 95% CI 0.35-3.07; p=0.95). Ursodeoxycholic acid treatment also had no effect on the prevalence of stillbirth when considering only randomised controlled trials (aOR 0.29, 95% CI 0.04-2.42; p=0.25). Ursodeoxycholic acid treatment had no effect on the prevalence of the composite outcome in all studies (aOR 1.28, 95% CI 0.86-1.91; p=0.22), but was associated with a reduced composite outcome when considering only randomised controlled trials (0.60, 0.39-0.91; p=0.016). Interpretation Ursodeoxycholic acid treatment had no significant effect on the prevalence of stillbirth in women with intrahepatic cholestasis of pregnancy, but our analysis was probably limited by the low overall event rate. However, when considering only randomised controlled trials, ursodeoxycholic acid was associated with a reduction in stillbirth in combination with preterm birth, providing evidence for the clinical benefit of antenatal ursodeoxycholic acid treatment. Copyright (C) 2021 The Authors(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 3. |
- Abelev, Betty, et al.
(författare)
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Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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| 4. |
- Abelev, Betty, et al.
(författare)
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Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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| 5. |
- Gabry, Frédéric, et al.
(författare)
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Cooperation for Secure Broadcasting in Cognitive Radio Networks
- 2012
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Ingår i: Communications (ICC), 2012 IEEE International Conference on. - : IEEE. - 9781457720529 ; , s. 5613-5618
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Konferensbidrag (refereegranskat)abstract
- This paper explores the trade-off between cooperation and secrecy in cognitive radio networks. We consider a scenario consisting of a primary and a secondary system. In the simplest case, each system is represented by a pair of transmitter and receiver. We assume a secrecy constraint on the transmission in the sense that the message of the primary transmitter has to be concealed from the secondary receiver. Both situations where the secondary transmitter is aware and unaware of the primary message are investigated and compared. In the first case, the secondary transmitter helps by allocating power for jamming, which increases the secrecy of the first message. In the latter case, it can also act as a relay for the primary message, thus improving the reliability of the primary transmission. Furthermore, we extend our results to the scenario where the secondary system comprises multiple receivers. For each case we present achievable rate regions. We then provide numerical illustrations for these rate regions. Our main result is that, in spite of the secrecy constraint, cooperation is beneficial in terms of the achievable rates. In particular, the secondary system can achieve a significant rate without decreasing the primary rate below the benchmark rate achievable without the help of the secondary transmitter. Finally, we investigate the influence of the distances between users on the system's performance.
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| 6. |
- Gabry, Frédéric, et al.
(författare)
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On the Optimization of the Secondary Transmitter's Strategy in Cognitive Radio Channels with Secrecy
- 2014
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Ingår i: IEEE Journal on Selected Areas in Communications. - 0733-8716 .- 1558-0008. ; 32:3, s. 451-463
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Tidskriftsartikel (refereegranskat)abstract
- This paper investigates cooperation for secrecy in cognitive radio networks. In particular, we consider a four-node cognitive scenario where the secondary receiver is treated as a potential eavesdropper with respect to the primary transmission. The cognitive transmitter can help the primary transmission, and it should also ensure that the primary message is not leaked to the secondary user. We consider two cognitive scenarios depending on whether the secondary transmitter knows the primary message or not. In the first case, the secondary transmitter is unaware of the primary transmitter's message and acts as a helping interferer to enhance the secrecy of the primary transmission, whereas in the second case, relaying of the primary message is also within its capabilities. First, we find achievable rate regions for these two scenarios in the case of AWGN channels. We then investigate three different optimization problems: the maximization of the primary rate, the maximization of the secondary rate and the minimization of the secondary transmit power. For these optimization problems, we find closed-form expressions in important special cases. Furthermore, we analyze the cooperation between the primary and secondary transmitters from a game-theoretic perspective. We model their interaction as a Stackelberg game, for which we define and find the Stackelberg equilibrium. Finally, we use numerical examples to illustrate the rate regions, the three optimizations, and the impact of the Stackelberg game on the achievable rates and on the transmission strategies of the secondary transmitter.
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| 7. |
- Gabry, Frédéric, et al.
(författare)
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Secure Broadcasting in Cooperative Cognitive Radio Networks
- 2012
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Ingår i: 2012 Future Network and Mobile Summit, FutureNetw 2012. - : IIMC. - 9781905824304
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Konferensbidrag (refereegranskat)abstract
- This paper explores the trade-off between cooperation and secrecy in cognitive radio networks. We consider a scenario consisting of a primary and a secondary system. In the simplest case, each system is represented by a pair of transmitter and receiver. We assume a secrecy constraint on the transmission in the sense that the message of the primary transmitter has to be concealed from the secondary user. Both situations where the secondary transmitter is aware and unaware of the primary message are investigated and compared. Furthermore, we extend our results to the scenario where the secondary system comprises multiple users. For each case we sketch the derivation of the rates that are achievable from an information theoretic perspective. We then investigate the findings by numerical simulations. Our main result is that, in spite of the secrecy constraint, cooperation is beneficial in terms of the achievable rates. The secondary transmitter has the two contradicting tasks of helping the primary system and transmitting its own message. Our results show that both tasks can be accomplished simultaneously, improving both systems' performance. In particular, the secondary system can achieve a significant rate without decreasing the primary rate below the benchmark rate achievable without the help of the secondary transmitter. In the case of multiple secondary users, the rate region reduces, which results in a lower individual rate. However, the linear increase in sumrate counterbalances this effect.
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| 8. |
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| 9. |
- Girnyk, Maksym, 1984-
(författare)
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A Statistical-Physics Approach to the Analysisof Wireless Communication Systems
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Multiple antennas at each side of the communication channel seem to be vital for future wireless communication systems. Multi-antenna communication provides throughput gains roughly proportional to the smallest number of antennas at the communicating terminals. On the other hand, multiple antennas at a terminal inevitably increase the hardware complexity of the latter. For efficient design of such systems relevant mathematical tools, capable of capturing the most significant features of the wireless multi-antenna channel - such as fading, spatial correlation, interference - are essential.This thesis, based on the asymptotic methods from statistical physics and random matrix theory, develops a series of asymptotic approximations for various metrics characterizing the performance of multi-antenna systems in different settings. The approximations become increasingly precise as the number of antennas at each terminal grows large and are shown to significantly simplify the performance analysis. This, in turn, enables efficient performance optimization, which would otherwise be intractable.After a general introduction, provided in Chapter 2, this thesis provides four different applications of large-system analysis. Thus, Chapter 3 analyzes multi-antenna multiple-access channel in the presence of non-Gaussian interference. The obtained large-system approximation of the sum rate is further used to carry out the precoder optimization routine for both Gaussian and finite-alphabet types of inputs. Meanwhile, Chapter 4 carries out the large-system analysis for a multi-hop relay channel with an arbitrary number of hops. Suboptimality of some conventional detectors has been captured through the concept of generalized posterior mean estimate. The obtained decoupling principle allows performance evaluation for a number of conventional detection schemes in terms of achievable rates and bit error rate. Chapter 5, in turn, studies achievable secrecy rates of multi-antenna wiretap channels in three different scenarios. In the quasi-static scenario, an alternating-optimization algorithm for the non-convex precoder optimization problem is proposed. The algorithm is shown to outperform the existing solutions, and it is conjectured to provide a secrecy capacity-achieving precoder. In the uncorrelated ergodic scenario, a large-system analysis is carried out for the ergodic secrecy capacity yielding a closed-form expression. In the correlated ergodic scenario, the obtained large-system approximation is used to address the corresponding problem of precoder optimization. Finally, Chapter6 addresses a practical case of random network topology for two scenarios: i) cellular mobile networks with randomly placed mobile users and ii) wiretap channel with randomly located eavesdroppers. Large-system approximations for the achievable sum rates are derived for each scenario, yielding simplified precoder optimization procedures for various system parameters.
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| 10. |
- Girnyk, Maksym, 1984-, et al.
(författare)
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Asymptotic properties of dual-hop AF relay MIMO communication systems
- 2014
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Ingår i: 2014 IEEE International Symposium on Information Theory (ISIT). - : IEEE conference proceedings. - 9781479951864 ; , s. 476-480
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Konferensbidrag (refereegranskat)abstract
- The present paper studies the asymptotic performance of dual-hop amplify-and-forward multiple-input multiple-output relay communication systems. In the corresponding setup, a relay amplifies the signal received from a source, retransmitting it towards a destination, while the direct source-destination link is absent. Ergodic achievable rates under separate decoding, along with the average bit error rate under various detection schemes are derived in the regime where the number of antennas at each terminal grows without bound. To overcome the mathematical difficulty of averaging over both channel realizations and input signals we apply large-system analysis based on the replica method from statistical physics. The validity of the large-system analysis is further verified through Monte Carlo simulations, providing particularly good accuracy at low SNR.
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