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- Hansson, Emma C., 1985, et al.
(författare)
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Platelet function recovery after ticagrelor withdrawal in patients awaiting urgent coronary surgery
- 2017
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Ingår i: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. - : Oxford University Press (OUP). - 1010-7940 .- 1873-734X. ; 51:4, s. 633-637
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Dual antiplatelet therapy with ticagrelor and aspirin is associated with an increased risk of perioperative bleeding complications. Current guidelines recommend therefore discontinuation of ticagrelor 5 days before surgery to allow sufficient recovery of platelet function. It is not known how the time to recovery varies between individual patients after discontinuation of ticagrelor. METHODS: Twenty-five patients accepted for urgent coronary artery bypass surgery and treated with ticagrelor and aspirin were included in a prospective observational study. Platelet aggregation was evaluated with impedance aggregometry at five timepoints 12-96 h after discontinuation of ticagrelor. In a subset of patients (n = 15), we also tested the ex vivo efficacy of platelet concentrate supplementation on platelet aggregation. RESULTS: There was a gradual increase in mean adenosine diphosphate-induced platelet aggregation after discontinuation of ticagrelor. After 72 h, mean aggregation was 38 +/-23 aggregation units (U), which is above a previously suggested cut-off of 22 U, when patients can be operated without increased bleeding risk. However, there was a large interindividual variability (range 488 U at 72 h) and 6/24 patients (25%) had <22 U after 72 h. Ex vivo administration of platelet concentrate did not improve adenosine diphosphate-induced aggregation at any timepoint after ticagrelor discontinuation. CONCLUSIONS: Adenosine diphosphate-induced aggregation was acceptable after 72 h in the majority of patients but with a large interindividual variability. Due to the large variability, platelet function testing may prove to be a valuable tool in timing of surgery in patients with ongoing or recently stopped ticagrelor treatment. Adenosine diphosphate-induced aggregation was not improved by addition of platelet concentrate.
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- Leontowitsch, Miranda, et al.
(författare)
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Participatory action research on webs of caring in the digital age across four European countries
- 2023
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Ingår i: Quality in Ageing and Older Adults. - West Yorkshire : Emerald Group Publishing Limited. - 2044-1827 .- 2044-1835.
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The digital age requires people of all ages to communicate and organise their lives through digital technologies. The project EQualCare investigates how the growing population of older people living alone is managing this transition, how it shapes their (non-)digital social networks and what changes on a local level need to be brought about. This paper aims to give insight into the process of participatory action research (PAR) with older people in the community across four countries and reflects on experiences made by academic and co-researchers.Design/methodology/approach: Following the emancipatory underpinnings of PAR, which aims to reduce inequalities through collaboration and co-design, EQualCare involved nine teams of co-researchers across Finland, Germany, Latvia and Sweden making older people the centre of policy development. Co-researchers were involved in formulating research aims, collecting data, reflecting on data, formulating and disseminating recommendations for local policy stakeholders.Findings: Co-researchers’ motivation to invest considerable time and effort was driven by a desire to create a more equal future for older people living alone. Moreover, they were keen to involve marginalised older people and became frustrated when this proved difficult. Power dynamics played a role throughout the process but became productive as roles and responsibilities were renegotiated. Doing PAR with older people can be emotionally challenging for co-researchers when negative feelings around ageing are encountered.Originality/value: The paper advances understanding on the process of PAR in ageing research by reflecting on the social, cultural and political contexts of doing PAR with diverse sets of older people.
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- Leontowitsch, Miranda, et al.
(författare)
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Participatory action research on webs of caring in the digital age across four European countries
- 2024
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Ingår i: Quality in Ageing and Older Adults (QAOA). - : Emerald Group Publishing Limited. - 2044-1827 .- 2044-1835. ; 25:1, s. 21-32
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Tidskriftsartikel (refereegranskat)abstract
- Purpose The digital age requires people of all ages to communicate and organise their lives through digital technologies. The project EQualCare investigates how the growing population of older people living alone is managing this transition, how it shapes their (non-)digital social networks and what changes on a local level need to be brought about. This paper aims to give insight into the process of participatory action research (PAR) with older people in the community across four countries and reflects on experiences made by academic and co-researchers. Design/methodology/approach Following the emancipatory underpinnings of PAR, which aims to reduce inequalities through collaboration and co-design, EQualCare involved nine teams of co-researchers across Finland, Germany, Latvia and Sweden making older people the centre of policy development. Co-researchers were involved in formulating research aims, collecting data, reflecting on data, formulating and disseminating recommendations for local policy stakeholders. Findings Co-researchers' motivation to invest considerable time and effort was driven by a desire to create a more equal future for older people living alone. Moreover, they were keen to involve marginalised older people and became frustrated when this proved difficult. Power dynamics played a role throughout the process but became productive as roles and responsibilities were renegotiated. Doing PAR with older people can be emotionally challenging for co-researchers when negative feelings around ageing are encountered. Originality/value The paper advances understanding on the process of PAR in ageing research by reflecting on the social, cultural and political contexts of doing PAR with diverse sets of older people.
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- Lundwall, Åke, et al.
(författare)
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Molecular cloning of complementary DNA encoding mouse seminal vesicle-secreted protein SVSI and demonstration of homology with copper amine oxidases
- 2003
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Ingår i: Biology of Reproduction. - : Oxford University Press (OUP). - 1529-7268 .- 0006-3363. ; 69:6, s. 1923-1930
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Tidskriftsartikel (refereegranskat)abstract
- The primary structure of mouse SVS I was determined by peptide sequencing and nucleotide sequencing of cloned cDNA. The precursor molecule consists of 820 amino acid residues, including a signal peptide of 24 residues, and the mature polypeptide chain of 91 kDa has one site for potential N-linked glycosylation. The SVS I is homologous with amiloride-binding protein 1 (ABP1), a diamine oxidase. However, it probably lacks enzymatic activity, because the cDNA codes for His instead of Tyr at the position of the active-site topaquinon. The SVS I monomer probably binds one molecule of copper, because the His residues coordinated by Cu(II) are conserved. The SVS I gene consists of five exons and is situated on mouse chromosome 6,B2.3. It is located in a region of 100 kilobases (kb) containing several genes with homology to SVS 1, including the gene of ABP1 and two other proteins with homology to diamine oxidase. The locus is conserved on rat chromosome 4q24, but the homologous region on human chromosome 7q34-q36 solely contains ABP1. The other genes with homology to diamine oxidase were probably present in a progenitor of primates and rodents but were lost in the evolutionary lineage leading to humans-presumably during recombination between chromosomes. The estimated molecular mass of rat SVS I is 102 kDa (excluding glycosylation). The species difference in size of SVS I is caused by tandem repeats of 18 amino acid residues in the central part of the molecule: The mouse has seven repeats, and the rat has 12 repeats.
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- Malm, Camilla, et al.
(författare)
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A balance between putting on the researcher's hat and being a fellow human being : a researcher perspective on informal carer involvement in health and social care research
- 2022
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Ingår i: Health Research Policy and Systems. - : BioMed Central (BMC). - 1478-4505. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Public involvement in health and social care research is increasingly prioritized by policy-makers and research funders. Often, the impact of the involvement is described in terms of how it has contributed to the research outcomes and how it has affected the involved members of the public. There is a dearth of studies reporting from the perspective of researchers themselves of having involved members of the public in their research. Nevertheless, there is a general expectation for researchers to accept and embrace public involvement in research. This study aims to explore researchers' views of involving informal carers in health and social care research. Methods: Eleven individual in-depth interviews with researchers in the fields of social work, caring science, health science and medical science constituted the dataset of this qualitative study, inspired by discourse psychology. Results: The qualitative data analysis resulted in two interpretative repertoires describing researchers' views of involving informal carers in research, "Philosophy of Science " and "Personal relationships and growth ". Both repertoires need to be recognized; however, as of today, the Philosophy of Science repertoire is more acknowledged, while the second repertoire describing empathy, relationships and emotions may be viewed as the researcher being "unprofessional ". Further, the findings highlighted the dual perspective of being a researcher and a carer as creating opportunities for growth on the part of the researcher, on both a professional and a personal level. Conclusions: Researchers and their research work would benefit from acknowledging, discussing and reporting both interpretative repertoires in their publications, as well as recognizing the benefit of dialectal positions, for example, having a dual perspective as both a researcher and an informal carer.
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| 10. |
- Malm, Camilla, et al.
(författare)
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Carers' views and experiences of the co-creation of a national carer strategy
- 2019
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Ingår i: Presented at the International Association of Gerontology and Geriatrics European Region Congress 2019, Gothenburg, Sweden, May 23-25, 2019, 2019.
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Konferensbidrag (refereegranskat)abstract
- In Sweden, increasingly the care of older people is carried out by informal/family carers. That is, family members- adult children and spouses, but also relatives and friends. In the move towards people-centred, integrated care systems, there is a growing argument for carers to be seen as partners in care alongside the person they are caring for and health and care staff. Whilst there is an increasing awareness of carers’ role within service systems and their own needs for support, their involvement in research has not been systematically explored. One of the university nodes within the UserAge research programme, focuses on this theme. This presentation will examine recent research to create a national carer strategy in Sweden. In particular, to examine carers’ involvement during the research and development (R&D) process. An overview of the initial stages of the design process will be given drawing on the theoretical foundations for the work with reference to the temporal model of family caring and the carer as expert model. The presentation will focus on findings from a qualitative study (n=12) that explored how carers perceived R&D work and their own experiences of being involved in the development of a national carer strategy. Interview participants were purposively selected from those carers that participated in focus group interviews conducted in the earlier design phase. Main findings include the challenges and benefits of carer involvement in research and their aspirations and concerns regarding their involvement in research generally, and with regards to the national carer strategy. The discussion will examine the level of carers’ involvement and the significance of their involvement in the co-creation process of the national carer strategy. Concluding comments will highlight that genuine carer involvement in research also demands a high level of engagement from involved researchers and policymakers during the entire process.
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