| 1. |
- Ahlberg, Kerstin, 1947-, et al.
(författare)
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Monitoring compliance with labour standards : restriction of economic freedoms or effective protection of rights?
- 2014
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Ingår i: Regulating transnational labour in Europe. - Oslo : Privaträttsfondet. - 9788272362392 - 8272362392 ; , s. 187-216
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- From a labour law perspective different institutional arrangements for monitoring employment conditions are analysed primarily as means of effective protection of rights. From the perspective of market integration and particularly the free mobement of services, on the other hand, national monitoring measures are analysed primarily as restrictions of economic freedoms. The aim of this chapter is to analyse how these different perspectives on arrangements for monitoring labour standards for posted workers are reflected in the position taken by the EU institutions and the Member States.
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| 2. |
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| 3. |
- Andersson, Axel, et al.
(författare)
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Points2Regions : Fast, interactive clustering of imaging-based spatial transcriptomics data
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Imaging-based spatial transcriptomics techniques generate image data that, once processed, results in a set of spatial points with categorical labels for different mRNA species. A crucial part of analyzing downstream data involves the analysis of these point patterns. Here, biologically interesting patterns can be explored at different spatial scales. Molecular patterns on a cellular level would correspond to cell types, whereas patterns on a millimeter scale would correspond to tissue-level structures. Often, clustering methods are employed to identify and segment regions with distinct point-patterns. Traditional clustering techniques for such data are constrained by reliance on complementary data or extensive machine learning, limiting their applicability to tasks on a particular scale. This paper introduces 'Points2Regions', a practical tool for clustering spatial points with categorical labels. Its flexible and computationally efficient clustering approach enables pattern discovery across multiple scales, making it a powerful tool for exploratory analysis. Points2Regions has demonstrated efficient performance in various datasets, adeptly defining biologically relevant regions similar to those found by scale-specific methods. As a Python package integrated into TissUUmaps and a Napari plugin, it offers interactive clustering and visualization, significantly enhancing user experience in data exploration. In essence, Points2Regions presents a user-friendly and simple tool for exploratory analysis of spatial points with categorical labels.
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| 5. |
- Andersson, Jonas, et al.
(författare)
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Exact analysis of One-Warehouse-Multiple-Retailer inventory systems with quantity restricted deliveries
- 2023
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Ingår i: European Journal of Operational Research. - : Elsevier BV. - 0377-2217. ; 309:3, s. 1161-1172
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Tidskriftsartikel (refereegranskat)abstract
- Joint consideration and coordination of inventory and shipment decisions is an important challenge in the quest for sustainable distribution systems. This paper addresses this issue by presenting a method for exact analysis of the inventory level distributions in a centralized One-Warehouse-Multiple-Retailer (OWMR) inventory system with quantity restricted deliveries from the warehouse. The system is characterized by continuous review (R,nQ) policies, complete backordering, and compound Poisson demand. The class of quantity restricted delivery policies we consider is motivated by a common desire in practice to ship full load carriers. It generalizes the assumption of unrestricted partial deliveries often used in the literature, and allows the warehouse to only ship retailer specific delivery batch quantities to the different retailers. The delivery batches typically represent package or pallet sizes, containers, or full truckloads. An attractive feature of our approach is that it does not add to the computational effort of analyzing the special case of unrestricted partial deliveries available in the existing literature. A numerical study shows that accounting for quantitative delivery restrictions used in transportation and handling operations when optimizing the reorder points in multi-echelon systems can be very important. Failure to do so can lead to high backorder costs and inadequate customer service.
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| 6. |
- Bengtsson, Ylva, et al.
(författare)
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Serum copper, zinc and copper/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study
- 2023
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Ingår i: Redox Biology. - 2213-2317. ; 63
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe essential trace elements copper and zinc, and their ratio (copper/zinc), are important for maintaining redox homeostasis. Previous studies suggest that these elements may impact breast cancer survival. However, no epidemiological study has so far been conducted on the potential association between copper and copper/zinc levels and survival after breast cancer diagnosis. In this study, we aimed to examine the relationship between serum copper, zinc and copper/zinc levels and survival following breast cancer diagnosis.Patients and methodsThe Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a population-based cohort study including multiple participating hospitals in Sweden. A total of 1998 patients diagnosed with primary invasive breast cancer were followed for approximately nine years. Serum levels of copper and zinc and their ratio at the time of diagnosis was analyzed in relation to breast cancer survival using multivariate Cox regression, yielding hazard ratios (HR) with 95% confidence intervals.ResultsA higher copper/zinc ratio was associated with lower overall survival after breast cancer diagnosis. Comparing patients with a copper/zinc ratio in quartile 4 vs 1, the crude HR was 2.29 (1.65–3.19) (Ptrend ConclusionThere is evidence that the serum copper/zinc ratio provides an independent predictive value for overall survival following breast cancer diagnosis.
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| 7. |
- Björkdahl, Erika P, 1967-
(författare)
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Lojalitet och kontraktsliknande förhållanden : En civilrättslig studie av förutsättningarna för ansvar vid förhandlingar eller andra kontakter mellan avtalsmässigt obundna parter
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Björkdahl, E. P., 2007. Lojalitetsplikt och kontraktsliknande förhållanden. En civilrättslig studie av förutsättningarna för ansvar vid förhandlingar och andra kontakter mellan avtalsmässigt obundna parter A Pre-Contractual Basis for Liability - A Private Law Study of the Conditions for Liability based on Negotiations and Other Contacts between Parties not Contractually Bound.The research objective of this dissertation is to investigate and clarify those behaviors in negotiations and other contacts between parties not contractually bound that are not viewed as acceptable in the sense that they can result in private law sanctions. The objective in general with this dissertation is to provide a systematization that can be used in an explanatory model for a basis of liability with respect to blameworthy behavior with negotiations and other contacts in non-contractual situations. Included in this objective is clarifying under which circumstances pure economic losses that have arisen in such situations can be compensated. The study begins with certain contractual regulations in order to examine the criteria that can be viewed as included in the explanatory model as to that which is a basis for liable behavior.The first main part of the dissertation, concerns situations in which the preparatory contacts between two parties lead to a contract. Mapped out in this part is a number of selected contract law regulations. The ambition of this approach is to delineate with the help of these regulations an action norm that can be utilized in the investigation of that which is blameworthy behavior with negotiations and other contacts between parties not contractually bound. In the second main part of the dissertation conclusions from the first part are applied on the non-contractual area. This part concerns situations in which the preparatory contacts are focused on a contract being entered into later between those parties communicating with each other, but in which a contract for different reasons is not executed and such situations in which contacts have the purpose of creating a basis or information to an agreement that is to be taken with another party outside of these contacts.
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| 8. |
- Björkström, Niklas K, et al.
(författare)
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Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
- 2011
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 208:1, s. 13-21
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Tidskriftsartikel (refereegranskat)abstract
- Natural killer (NK) cells are known to mount a rapid response to several virus infections. In experimental models of acute viral infection, this response has been characterized by prompt NK cell activation and expansion followed by rapid contraction. In contrast to experimental model systems, much less is known about NK cell responses to acute viral infections in humans. We demonstrate that NK cells can rapidly expand and persist at highly elevated levels for >60 d after human hantavirus infection. A large part of the expanding NK cells expressed the activating receptor NKG2C and were functional in terms of expressing a licensing inhibitory killer cell immunoglobulin-like receptor (KIR) and ability to respond to target cell stimulation. These results demonstrate that NK cells can expand and remain elevated in numbers for a prolonged period of time in humans after a virus infection. In time, this response extends far beyond what is considered normal for an innate immune response.
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| 9. |
- Brueffer, Christian, et al.
(författare)
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Abstract P4-09-03: On the development and clinical value of RNA-sequencing-based classifiers for prediction of the five conventional breast cancer biomarkers: A report from the population-based multicenter SCAN-B study
- 2018
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Ingår i: Cancer research. Supplement. - 1538-7445. ; 78:4
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Konferensbidrag (refereegranskat)abstract
- Background:In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and treatment: estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (ERBB2/HER2), Ki67, and Nottingham histological grade (NHG). We aimed to develop classifiers for these biomarkers based on tumor mRNA-sequencing (RNA-seq), compare classification performance to conventional histopathology, and test whether RNA-seq-based predictors could add value for patient risk-stratification.Patients and Methods:In total, 3678 breast tumors were studied. For 405 breast tumors in the training cohort, a comprehensive histopathological biomarker evaluation was performed by three pathology readings to estimate inter-pathologist variability on the original diagnostic slides as well as on repeat immunostains for this study, and the consensus biomarker status for all five conventional biomarkers was determined. Whole transcriptome gene expression profiling was performed by RNA-sequencing on the Illumina platform. Using RNA-seq-derived tumor gene expression data as input, single-gene classifiers (SGC) and multi-gene classifiers (MGC) were trained on the consensus pathology biomarker labels. The trained classifiers were tested on an independent prospective population-based series of 3273 primary breast cancer cases from the multicenter SCAN-B study with median 41 months follow-up (ClinicalTrials.gov identifier NCT02306096), and classifications were evaluated by agreement statistics and by Kaplan-Meier and Cox regression survival analyses.Results:For the histopathological evaluation, pathologist evaluation concordance was high for ER, PgR, and HER2 (average kappa values of .920, .891, and .899, respectively), but moderate for Ki67 and NHG (.734 and .581). Classification concordance between RNA-seq classifiers and histopathology for the independent 3273-cohort was similar to that within histopathology assessments, with SGCs slightly outperforming MGCs. Importantly, patients with discordant results, classified as hormone responsive (HoR+) by histopathology but non-hormone responsive by MGC, presented with significantly inferior overall survival compared to patients with concordant results. These results extended to patients with no adjuvant systemic therapy (hazard ratio, HR, 4.54; 95% confidence interval, CI, 1.42-14.5), endocrine therapy alone (HR 3.46; 95% CI, 2.01-5.95), or receiving chemotherapy (HR 2.57; 95% CI 1.13-5.86). For HoR+ cases receiving endocrine therapy alone, the MGC HoR classifier remained significant after multivariable adjustment (HR 3.14; 95% CI, 1.75-5.65).Conclusions:RNA-seq-based classifiers for the five key early breast cancer biomarkers were generally equivalent to conventional histopathology with regards to classification error rate. However, when benchmarked using overall survival, our RNA-seq classifiers provided added clinical value in particular for cases that are determined by histopathology to be hormone-responsive but by RNA-seq appear hormone-insensitive and have a significantly poorer outcome when treated with endocrine therapy alone
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| 10. |
- Brueffer, Christian, et al.
(författare)
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Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative
- 2018
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Ingår i: JCO Precision Oncology. - 2473-4284. ; 2, s. 1-18
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Tidskriftsartikel (refereegranskat)abstract
- PurposeIn early breast cancer (BC), five conventional biomarkers—estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), Ki67, and Nottingham histologic grade (NHG)—are used to determine prognosis and treatment. We aimed to develop classifiers for these biomarkers that were based on tumor mRNA sequencing (RNA-seq), compare classification performance, and test whether such predictors could add value for risk stratification.MethodsIn total, 3,678 patients with BC were studied. For 405 tumors, a comprehensive multi-rater histopathologic evaluation was performed. Using RNA-seq data, single-gene classifiers and multigene classifiers (MGCs) were trained on consensus histopathology labels. Trained classifiers were tested on a prospective population-based series of 3,273 BCs that included a median follow-up of 52 months (Sweden Cancerome Analysis Network—Breast [SCAN-B], ClinicalTrials.gov identifier: NCT02306096), and results were evaluated by agreement statistics and Kaplan-Meier and Cox survival analyses.ResultsPathologist concordance was high for ER, PgR, and HER2 (average κ, 0.920, 0.891, and 0.899, respectively) but moderate for Ki67 and NHG (average κ, 0.734 and 0.581). Concordance between RNA-seq classifiers and histopathology for the independent cohort of 3,273 was similar to interpathologist concordance. Patients with discordant classifications, predicted as hormone responsive by histopathology but non–hormone responsive by MGC, had significantly inferior overall survival compared with patients who had concordant results. This extended to patients who received no adjuvant therapy (hazard ratio [HR], 3.19; 95% CI, 1.19 to 8.57), or endocrine therapy alone (HR, 2.64; 95% CI, 1.55 to 4.51). For cases identified as hormone responsive by histopathology and who received endocrine therapy alone, the MGC hormone-responsive classifier remained significant after multivariable adjustment (HR, 2.45; 95% CI, 1.39 to 4.34).ConclusionClassification error rates for RNA-seq–based classifiers for the five key BC biomarkers generally were equivalent to conventional histopathology. However, RNA-seq classifiers provided added clinical value in particular for tumors determined by histopathology to be hormone responsive but by RNA-seq to be hormone insensitive.
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