| 1. |
- Tschiderer, L., et al.
(författare)
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Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies
- 2023
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Ingår i: Journal of the American Heart Association (JAHA). - 2047-9980. ; 12:12
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and ResultsWe undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). ConclusionsOur large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
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| 2. |
- Tschiderer, Lena, et al.
(författare)
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Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies
- 2023
-
Ingår i: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 12:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development.Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques).Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
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| 3. |
- David, J. C., et al.
(författare)
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Modeling astatine production in liquid lead-bismuth spallation targets
- 2013
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 49:3
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Tidskriftsartikel (refereegranskat)abstract
- Astatine isotopes can be produced in liquid lead-bismuth eutectic targets through proton-induced double charge exchange reactions on bismuth or in secondary helium-induced interactions. Models implemented into the most common high-energy transport codes generally have difficulties to correctly estimate their production yields as was shown recently by the ISOLDE Collaboration, which measured release rates from a lead-bismuth target irradiated by 1.4 and 1 GeV protons. In this paper, we first study the capability of the new version of the Liege intranuclear cascade model, INCL4.6, coupled to the de-excitation code ABLA07 to predict the different elementary reactions involved in the production of such isotopes through a detailed comparison of the model with the available experimental data from the literature. Although a few remaining deficiencies are identified, very satisfactory results are found, thanks in particular to improvements brought recently on the treatment of low-energy helium-induced reactions. The implementation of the models into MCNPX allows identifying the respective contributions of the different possible reaction channels in the ISOLDE case. Finally, the full simulation of the ISOLDE experiment is performed, taking into account the likely rather long diffusion time from the target, and compared with the measured diffusion rates for the different astatine isotopes, at the two studied energies, 1.4 and 1 GeV. The shape of the isotopic distribution is perfectly reproduced as well as the absolute release rates, assuming in the calculation a diffusion time between 5 and 10 hours. This work finally shows that our model, thanks to the attention paid to the emission of high-energy clusters and to low-energy cluster induced reactions, can be safely used within MCNPX to predict isotopes with a charge larger than that of the target by two units in spallation targets, and, probably, more generally to isotopes created in secondary reactions induced by composite particles.
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| 4. |
- La Tessa, Chiara, 1979, et al.
(författare)
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Test of weak and strong factorization in nucleus-nucleus collisions at several hundred MeV/nucleon
- 2007
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Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 791:3-4, s. 434-450
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Tidskriftsartikel (refereegranskat)abstract
- Projectile total and partial charge-changing cross sections have been measured for argon ions at 400 MeV/nucleon in carbon, aluminum, copper, tin and lead targets; cross sections for hydrogen were also obtained using a polyethylene target. The validity of weak and strong factorization properties has been investigated for partial charge-changing cross sections; measurements obtained for carbon, neon and silicon beams at 290 and 400 MeV/nucleon and iron beam at 400 MeV/nucleon, in carbon, aluminum, copper, tin and lead targets have also been used for the test. Two different analysis methods were applied and both indicated that these properties are valid, without any significant difference between weak and strong factorization. The factorization parameters have then been calculated and analyzed in order to find some systematic behavior useful for modeling purposes. (C) 2007 Elsevier B.V. All rights reserved.
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| 5. |
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| 6. |
- Mancusi, C., et al.
(författare)
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Impact of isolated systolic hypertension on normalization of left ventricular structure during antihypertensive treatment in patients with electrocardiographic left ventricular hypertrophy (LIFE)
- 2013
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 34:Supplement: 1, s. 597-597
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Objective: Hypertension is associated with changes in left ventricular(LV) mass and geometry. We tested the impact of isolated systolichypertension (ISH) on normalization of LV structure during antihypertensive treatment.Methods: Baseline and annual echocardiograms were recorded in 875 hypertensive patients with electrocardiographic signs of LV hypertrophy during 4.8 years randomized losartan or atenolol-based antihypertensive treatment in the Losartan Intervention For Endpoint (LIFE) reduction inhypertension study.Results: Patients with ISH at baseline (n=128) were older, included more women, patients with diabetes or previous myocardial infarctioncompared to non-ISH patients (n=747) (all p<0.05). Baseline systolicblood pressure (BP), LV mass and ejection fraction (EF) did not differ between groups, while pulse pressure/stroke volume index (PP/SVi, an index of arterial stiffness) was higher in the ISH group (p<0.01). At the final study visit, systolic BP, LV mass, relative wall thickness (RWT) and PP/SVi were higher in the ISH group (all p<0.05). In particular, ISH patients had less reduction in LV mass and more residual LV hypertrophy compared to non-ISH patients (p<0.05). In multivariate analysis, ISH at baseline predicted higher LV mass at study end (β=0.53) independent ofhigher baseline LV mass (β=0.54) body mass index (β=0.10), atenolol-based treatment (β=0.09), and higher systolic BP (β=0.07), RWT (β=0.23) and lower LV EF (β=-0.24) at the final visit (all p<0.05), while age, historyof diabetes and PP/SVi were not significant covariates in the model.Conclusions: Antihypertensive treatment is associated with impairednormalization of LV mass and LV geometry in ISH patients with ECG LV hypertrophy. The findings may help explain the higher cardiovascular event-rate previously reported in LIFE ISH-patients.
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| 7. |
- Mancusi, Davide, 1980, et al.
(författare)
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PHITS - benchmark of partial charge-changing cross sections for intermediate-mass systems
- 2007
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 254:1, s. 30-38
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Tidskriftsartikel (refereegranskat)abstract
- The PHITS (Particle and Heavy Ion Transport System) code is a three-dimensional Monte Carlo code that is able to simulate the transport of nuclei and other particles in complicated geometries and calculate fluxes, doses, energy-deposition distributions and many other observables. Among its many possible fields of application, it can be used e.g. to design and optimise radiation shields for space vessels. However, the reliability of the predictions of the code depends directly on the certified accuracy of the code components, i.e. the models the code uses to estimate the quantities necessary for the transport calculation. As a part of a comprehensive benchmarking program, we have investigated the possibility of using PHITS to calculate partial charge-changing cross sections and we have compared the results with measurements performed by some of us (CZ, LH, JM, SG). The results, although limited, suggest that the current reaction-cross-section models might be inadequate for use in space radioprotection; we therefore claim the need for a thorough benchmarking of the models and for new reaction-cross-section measurements and experimental techniques.
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| 8. |
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| 9. |
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| 10. |
- Sihver, Lembit, 1962, et al.
(författare)
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Bench marking of calculated projectile fragmentation cross sections using the 3-D, MC codes PHITS, FLUKA, HETC-HEDS, MCNPX_HI, and NUCFRG2
- 2008
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Ingår i: Acta Astronautica. - : Elsevier BV. - 0094-5765. ; 63:7-10, s. 865-877
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Tidskriftsartikel (refereegranskat)abstract
- Particles and heavy ions are used in various fields of nuclear physics, medical physics, and material science, and their interactions with different media, including human tissue and critical organs, have therefore carefully been investigated both experimentally and theoretically since the 1930s. However, heavy-ion transport includes many complex processes and measurements for all possible systems, including critical organs, would be impractical or too expensive e.g. direct measurements of dose equivalents to critical organs in humans cannot be performed. A reliable and accurate particle and heavy-ion transport code is therefore an essential tool in the design study of accelerator facilities as well as for other various applications. Recently, new applications have also arisen within transmutation and reactor science, space and medicine, especially radiotherapy, and several accelerator facilities are operating or planned for construction. Accurate knowledge of the physics of interaction of particles and heavy ions is also necessary for estimating radiation damage to equipment used on space vehicles, to calculate the transport of the heavy ions in the galactic cosmic ray (GCR) through the interstellar medium, and the evolution of the heavier elements after the Big Bang. Concerns about the biological effect of space radiation and space dosimetry are increasing rapidly due to the perspective of long-duration astronaut missions, both in relation to the International Space Station and to manned interplanetary missions in near future. Radiation protection studies for crews of international flights at high altitude have also received considerable attention in recent years. There is therefore a need to develop accurate and reliable particle and heavy-ion transport codes. To be able to calculate complex geometries, including production and transport of protons, neutrons, and alpha particles, 3-dimensional transport using Monte Carlo (MC) technique must be used. Today several particle and heavy-ion MC transport codes exist, e.g. Particle and Heavy-Ion Transport code System (PHITS), High Energy Transport Code-Human Exploration and Development of Space (HETC-HEDS). SHIELD-HIT, GEANT4, FLUKA. MARS. and MCNPX. In this paper, we present an extensive benchmarking of the calculated projectile fragmentation cross-sections from the reactions of 300-1000MeV/u Si-28, Ar-40, and Fe-56 on polyethylene, carbon. aluminum. and copper targets (relevant to space radioprotection) using PHITS, FLUKA, HETC-HEDS, and MCNPX, against measurements. The influence of the different models used in the different transport codes on the calculated results is also discussed. Some measured cross-sections are also compared to the calculated cross-sections using NUCFRG2, which are incorporated in the 1-dimensional, deterministic radiation transport code HZETRN.
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