| 1. |
- Zhang, Jiao-Long, et al.
(författare)
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Assessment of the Added Value of Multiscale Modeling of Concrete for Structural Analysis of Segmental Tunnel Rings
- 2021
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Ingår i: Encyclopedia of Materials. - : Elsevier. - 9780128197318 - 9780128197240 ; , s. 69-78
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Bokkapitel (refereegranskat)abstract
- This contribution deals with an assessment of the added value resulting from the use of a multiscale model of concrete as the basis for structural analysis of a segmental tunnel ring. The assessment rests on the comparison of a triad of results. They are obtained from a real-scale test of a segmental tunnel ring, from conventional structural analysis based on the concrete model of the fib Model Code, and from multiscale structural analysis based on a more recently developed multiscale model of concrete. In the experiment, a segmental tunnel ring was subjected to point loads simulating ground pressure. For both modes of structural analysis, a nonlinear hybrid method was used. It is termed hybrid, because not only the external loading was part of the input, but also the displacements at the joints were measured during testing. The method is nonlinear, because bending-induced cracking of concrete is accounted for. The analyzed segmental tunnel ring was subdivided into elements that are either intact or contain one central crack band. Structural analysis was based on transfer relations, representing analytical solutions of the linear theory of circular arches. As for the convergences, it is shown that conventional and multiscale structural analysis are equally reliable. Concerning cracking of concrete, it is demonstrated that multiscale structural analysis allows for a correct prediction of the initiation of cracking, while the results from conventional structural analysis overestimate the external loading at initiation of cracking by 86%. This underlines the added value of multiscale structural analysis for durability analysis of segmental tunnel linings with a designed service life of 100 years and more. © 2021 Elsevier Ltd. All rights reserved.
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| 2. |
- Gilling, Mette, et al.
(författare)
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Biparental inheritance of chromosomal abnormalities in male twins with non-syndromic mental retardation
- 2011
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Ingår i: European Journal of Medical Genetics. - : Elsevier BV. - 1769-7212. ; 54:4, s. 383-388
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Tidskriftsartikel (refereegranskat)abstract
- In a monozygotic twin couple with mental retardation (MR), we identified a maternally inherited inversion and a paternally inherited translocation: 46,XY,inv(10)(p11.2q21.2)mat,t(9;18)(p22;q21.1) pat. The maternally inherited inv(10) was a benign variant without any apparent phenotypical implications. The translocation breakpoint at 9p was within a cluster of interferon a genes and the 18q21 breakpoint truncated ZBTB7C (zinc finger and BTB containing 7C gene). In addition, analyses with array-CGH revealed a 931 kb maternally inherited deletion on chromosome 8q22 as well as an 875 kb maternally inherited duplication on 5p14. The deletion encompasses the RIM2 (Rab3A-interacting molecule 2), FZD6 (Frizzled homolog 6) and BAALC (Brain and Acute Leukemia Gene, Cytoplasmic) genes and the duplication includes the 5' end of the CDH9 (cadherin 9) gene. Exome sequencing did not reveal any additional mutations that could explain the MR phenotype. The protein products of the above mentioned genes are involved in different aspects of brain development and/or maintenance of the neurons which suggest that accumulation of genetic defects segregating from both parents might be the basis of MR in the twins. This hypothesis was further supported by protein interaction analysis. (C) 2011 Elsevier Masson SAS. All rights reserved.
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| 3. |
- Minocherhomjl, Sheroy, et al.
(författare)
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Sequence and expression analysis of gaps in human chromosome 20
- 2012
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Ingår i: Nucleic Acids Research. - : Oxford University Press. - 0305-1048 .- 1362-4962. ; 40:14, s. 6660-6672
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Tidskriftsartikel (refereegranskat)abstract
- The finished human genome-assemblies comprise several hundred un-sequenced euchromatic gaps, which may be rich in long polypurine/polypyrimidine stretches. Human chromosome 20 (chr 20) currently has three unfinished gaps remaining on its q-arm. All three gaps are within gene-dense regions and/or overlap disease-associated loci, including the DLGAP4 locus. In this study, we sequenced ~99% of all three unfinished gaps on human chr 20, determined their complete genomic sizes and assessed epigenetic profiles using a combination of Sanger sequencing, mate pair paired-end high-throughput sequencing and chromatin, methylation and expression analyses. We found histone 3 trimethylated at Lysine 27 to be distributed across all three gaps in immortalized B-lymphocytes. In one gap, five novel CpG islands were predominantly hypermethylated in genomic DNA from peripheral blood lymphocytes and human cerebellum. One of these CpG islands was differentially methylated and paternally hypermethylated. We found all chr 20 gaps to comprise structured non-coding RNAs (ncRNAs) and to be conserved in primates. We verified expression for 13 candidate ncRNAs, some of which showed tissue specificity. Four ncRNAs expressed within the gap at DLGAP4 show elevated expression in the human brain. Our data suggest that unfinished human genome gaps are likely to comprise numerous functional elements.
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| 4. |
- Zhang, Jiaolong, et al.
(författare)
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On the added value of multi-scale modeling of concrete
- 2022
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Ingår i: Frontiers of Structural and Civil Engineering. - : Springer. - 2095-2430 .- 2095-2449. ; 16:1, s. 1-23
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Tidskriftsartikel (refereegranskat)abstract
- This review of the added value of multi-scale modeling of concrete is based on three representative examples. The first one is concerned with the analysis of experimental data, taken from four high-dynamic tests. The structural nature of the high-dynamic strength increase can be explained by using a multi-scale model. It accounts for the microstructure of the specimens. The second example refers to multi-scale thermoelastic analysis of concrete pavements, subjected to solar heating. A sensitivity analysis with respect to the internal relative humidity (RH) of concrete has underlined the great importance of the RH for an assessment of the risk of microcracking of concrete. The third example deals with multi-scale structural analysis of a real-scale test of a segmental tunnel ring. It has turned out that multi-scale modeling of concrete enables more reliable predictions of crack opening displacements in tunnel segments than macroscopic models taken from codes of practice. Overall, it is concluded that multi-scale models have indeed a significant added value. However, its degree varies with these examples. In any case, it can be assessed by means of a comparison of the results from three sources, namely, multi-scale structural analysis, conventional structural analysis, and experiments.
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