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- Horsch, S., et al.
(författare)
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Randomized Control Trial of Postnatal rhIGF-1/rhIGFBP-3 Replacement in Preterm Infants: Post-hoc Analysis of Its Effect on Brain Injury
- 2020
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Ingår i: Frontiers in Pediatrics. - : Frontiers Media SA. - 2296-2360. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Background: Postnatal insulin-like growth factor-1 (IGF-1) replacement with recombinant human (rh)IGF-1 and IGF binding protein-3 (rhIGF-1/rhIGFBP-3) is being studied as a potential treatment to reduce comorbidities of prematurity. We have recently reported on a phase II, multicenter, randomized, controlled trial comparing postnatal rhIGF-1/rhIGFBP-3 replacement with standard of care (SOC) in extremely preterm infants (NCT01096784). Maximum severity of retinopathy of prematurity was the primary endpoint of the trial and presence of GMH-IVH/PHI one of the pre-specified secondary endpoints. Infants therefore received serial cranial ultrasound scans (CUS) between birth and term age. In this post-hoc analysis we present a detailed analysis of the CUS data of this trial and evaluate the effect of postnatal rhIGF-1/rhIGFBP-3 replacement on the incidence of different kinds of brain injury in extremely preterm infants. Methods: This report is an exploratory post-hoc analysis of a phase II trial in which infants <28 weeks gestational age were randomly allocated to rhIGF-1/rhIGFBP-3 or SOC. Serial cranial ultrasounds were performed between birth and term-equivalent age. Presence of germinal matrix hemorrhage and intraventricular hemorrhage (GMH-IVH), periventricular hemorrhagic infarction (PHI), post-hemorrhagic ventricular dilatation, and white matter injury (WMI) were scored by two independent masked readers. Results: The analysis included 117 infants; 58 received rhIGF-1/rhIGFBP-3 and 59 received SOC. A trend toward less grade II-III GMH-IVH and PHI was observed in treated infants vs. SOC. A subanalysis of infants without evidence of GMH-IVH at study entry (n = 104) showed reduced progression to GMH-IVH in treated infants (25.0% [13/52] vs. 40.4% [21/52]; not significant). No effects of rhIGF-1/rhIGFBP-3 on WMI were observed. Conclusion: The potential protective effect of rhIGF-1/rhIGFBP-3 on the occurrence of GMH-IVH/PHI appeared most pronounced in infants with no evidence of GMH-IVH at treatment start.
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- Rinaldi, S., et al.
(författare)
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A Cognitive Strategy for Renovation and Maintenance of Buildings through IoT Technology
- 2020
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Ingår i: Proceedings. - : IEEE Computer Society. - 9781728154145 ; , s. 1949-1954
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Konferensbidrag (refereegranskat)abstract
- Recently, designers of the home automation framework are looking to the Internet of Things (IoT) model to make it easier to deploy devices capable of gathering data from various plants. This situation is pushing a further evolution: from the conventional building automation, where the logic is determined by the installer or by the customer, to a cognitive system, capable of learning from the customers' preferences what the best plant configuration would be. The aim of this research work is to identify issues related to the implementation of cognitive solutions during the renovation process of buildings. The paper proposes a cognitive framework to help the operation and management phases of buildings, by means of the digitalization of the supply chain of the construction industry, from the single building aspect to the entire construction cycle. The paper presents the design of smart building elements with integrated capability to generate a massive amount of data for monitoring the energy and maintenance status of renovated buildings. The IoT paradigm has been used to link the physical word of building elements with the cognitive layer. The proposed approach has been applied and validated into a real test case. © 2020 IEEE.
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