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- Mangione, A., et al.
(författare)
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Estimation of pre-dolomitisation porosity and permeability of a nummulitic carbonate reservoir rock using the Multi-Component Architecture Method (MCAM)
- 2021
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Ingår i: Marine and Petroleum Geology. - : Elsevier BV. - 0264-8172. ; 132
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Tidskriftsartikel (refereegranskat)abstract
- The fossiliferous Eocene carbonate reservoir interval of the offshore Hasdrubal Field has a diagenetic history in which dolomitisation of micrite-rich facies has significantly enhanced reservoir quality. Using published information on the diagenetic evolution, digital textural representations of the limestones and dolostones are created using the Multi-Component Architecture Method (MCAM). This technique allows integration of images at different length scales (e.g., SEM, micro-/nano- XRT) which provide different forms of information about the pre-dolomitisation rock, including textural and compositional factors, and the arrangements of preserved components. These digital representations of the dolostones, together with their now completely overprinted precursor micritic limestones, permit exploration of the impact on porosity and permeability of uncemented, partly cemented and biomoulds Nummulites, their number per unit volume, and their orientation (i.e., uniformly or randomly orientated) allowing investigation of the petrophysical consequences of different distributions, orientations and abundances of the matrix and fossiliferous components. Viable diagenetic pathways, which were identified by thin section analysis as well as data available in the literature, are linked to petrophysical property evolution. In this way MCAM permits investigation of earlier stages of the diagenetic processes which were overprinted by later diagenetic processes.
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- Valleix, Sophie, et al.
(författare)
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D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Apolipoprotein C-III deficiency provides cardiovascular protection, but apolipoprotein C-III is not known to be associated with human amyloidosis. Here we report a form of amyloidosis characterized by renal insufficiency caused by a new apolipoprotein C-III variant, D25V. Despite their uremic state, the D25V-carriers exhibit low triglyceride (TG) and apolipoprotein C-III levels, and low very-low-density lipoprotein (VLDL)/high high-density lipoprotein (HDL) profile. Amyloid fibrils comprise the D25V-variant only, showing that wild-type apolipoprotein C-III does not contribute to amyloid deposition in vivo. The mutation profoundly impacts helical structure stability of D25V-variant, which is remarkably fibrillogenic under physiological conditions in vitro producing typical amyloid fibrils in its lipid-free form. D25V apolipoprotein C-III is a new human amyloidogenic protein and the first conferring cardioprotection even in the unfavourable context of renal failure, extending the evidence for an important cardiovascular protective role of apolipoprotein C-III deficiency. Thus, fibrate therapy, which reduces hepatic APOC3 transcription, may delay amyloid deposition in affected patients.
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