| 1. |
- Mansoori, Nasim, et al.
(författare)
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Serum Folic Acid and RFC A80G Polymorphism in Alzheimers Disease and Vascular Dementia
- 2014
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Ingår i: American Journal of Alzheimer’s Disease and Other Dementia. - : SAGE Publications (UK and US). - 1533-3175 .- 1938-2731. ; 29:1, s. 38-44
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Tidskriftsartikel (refereegranskat)abstract
- Low level of vitamin B12 and folic acid has been reported to play an important role in the pathogenesis of Alzheimer's disease (AD) and vascular dementia (VaD). Serum folic acid and vitamin B12 were assayed in 80 AD and 50 VaD cases and in 120 healthy controls. The reduced folate carrier (RFC1) gene, rs1051266, which encodes the RFC 1, protein was analyzed for polymorphism by polymerase chain reaction-restriction fragment length polymorphism. It was observed that the patients having folic acid <8.45 ng/mL had 2.4 (95% confidence interval [CI]: 1.4-4.5) times higher odds of having AD and 2.1 (95% CI: 1.1-4.2) times higher odds of having VaD than patients having folic acid ≥8.45 ng/mL. Serum vitamin B12 level did not show any such statistically significant effect in altering the odds. No direct association was found between variant (G) allele or genotype of rs1051266 with AD and VaD cases. On serum folate level no association was observed with gene polymorphism.
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| 2. |
- Milosavljevic, Stephan, et al.
(författare)
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Exploring how anthropometric, vehicle and workplace factors influence whole-body vibration exposures during on-farm use of a quad bike
- 2012
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Ingår i: International Journal of Industrial Ergonomics. - : Elsevier BV. - 0169-8141 .- 1872-8219. ; 42:4, s. 392-396
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Tidskriftsartikel (refereegranskat)abstract
- The primary aim of this study is to determine whether a combination of body height, terrain and vehicle mechanical factors confound for the effect of body mass on WBV exposure while using a quad bike under normal rural working conditions. A seat pad mounted triaxial accelerometer and data logger recorded full work day vibration and shock data from 130 New Zealand rural workers. Personal, vehicle and workplace characteristics were gathered using a modified version of the Whole Body Vibration Health Surveillance Questionnaire. Whole-body vibrations were analysed in accordance with the ISO 2631-1 and ISO 2631-5 standards and it is presented as one hour vibration dose value in the Z-direction (1 h VDVZ). Body mass did not demonstrate any significant bivariate association (P > 0.20) with I h VDVZ. However BMI, body height, vehicle weight, sheep farm, dairy farm, 2 shock absorber solid axle rear suspension, flat farmland and engine capacity (cc) all demonstrated threshold bivariate associations (P <= 0.20) with 1 h VDVZ. Body mass, body height, 2 shock absorber solid rear axle suspension, and working on a sheep farm created the strongest multiple regression model explaining 16% of variance in VDVZ. Relevance to industry: The influence of driver's body mass on vibration exposure is strongly influenced by work environment and vehicle mechanical factors and this should be taken in to consideration for research that explores exposures and/or designing seating and suspension systems to attenuate vibration exposures in small on-farm vehicles. (C) 2012 Elsevier B.V. All rights reserved.
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| 3. |
- Milosavljevic, Stephan, et al.
(författare)
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Exposure to whole-body vibration and mechanical shock : a field study of quad bike use in agriculture
- 2011
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Ingår i: Annals of Occupational Hygiene. - : Oxford University Press (OUP). - 0003-4878 .- 1475-3162. ; 55:3, s. 286-295
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The purpose of this study was to determine exposure to whole-body vibration (WBV) and mechanical shock in rural workers who use quad bikes and to explore how personal, physical, and workplace characteristics influence exposure. METHODS: A seat pad mounted triaxial accelerometer and data logger recorded full workday vibration and shock data from 130 New Zealand rural workers. Personal, physical, and workplace characteristics were gathered using a modified version of the Whole Body Vibration Health Surveillance Questionnaire. WBVs and mechanical shocks were analysed in accordance with the International Standardization for Organization (ISO 2631-1 and ISO 2631-5) standards and are presented as vibration dose value (VDV) and mechanical shock (S(ed)) exposures. RESULTS: VDV(Z) consistently exceeded European Union (Guide to good practice on whole body vibration. Directive 2002/44/EC on minimum health and safety, European Commission Directorate General Employment, Social Affairs and Equal Opportunities. 2006) guideline exposure action thresholds with some workers exceeding exposure limit thresholds. Exposure to mechanical shock was also evident. Increasing age had the strongest (negative) association with vibration and shock exposure with body mass index (BMI) having a similar but weaker effect. Age, daily driving duration, dairy farming, and use of two rear shock absorbers created the strongest multivariate model explaining 33% of variance in VDV(Z). Only age and dairy farming combined to explain 17% of the variance for daily mechanical shock. Twelve-month prevalence for low back pain was highest at 57.7% and lowest for upper back pain (13.8%). CONCLUSIONS: Personal (age and BMI), physical (shock absorbers and velocity), and workplace characteristics (driving duration and dairy farming) suggest that a mix of engineered workplace and behavioural interventions is required to reduce this level of exposure to vibration and shock.
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| 4. |
- Nijs, Jo, et al.
(författare)
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Central sensitisation in chronic pain conditions : latest discoveries and their potential for precision medicine
- 2021
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Ingår i: The Lancet Rheumatology. - : Elsevier. - 2665-9913. ; 3:5, s. E383-E392
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Forskningsöversikt (refereegranskat)abstract
- Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms represents a diagnostic challenge for rheumatology specialists. Central sensitisation, defined as an amplification of neural signalling within the CNS that elicits pain hypersensitivity, has been investigated as a reason for this discrepancy. Features of central sensitisation have been documented in various pain conditions common in rheumatology practice, including fibromyalgia, osteoarthritis, rheumatoid arthritis, Ehlers-Danlos syndrome, upper extremity tendinopathies, headache, and spinal pain. Within individual pain conditions, there is substantial variation among patients in terms of presence and magnitude of central sensitisation, stressing the importance of individual assessment. Central sensitisation predicts poor treatment outcomes in multiple patient populations. The available evidence supports various pharmacological and non-pharmacological strategies to reduce central sensitisation and to improve patient outcomes in several conditions commonly seen in rheumatology practice. These data open up new treatment perspectives, with the possibility for precision pain medicine treatment according to pain phenotyping as a logical next step. With this view, studies suggest the possibility of matching non-pharmacological approaches, or medications, or both to the central sensitisation pain
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