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- Ekstrom, M, et al.
(författare)
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mu SR investigation of single crystalline dysprosium
- 1997
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Ingår i: HYPERFINE INTERACTIONS. - : BALTZER SCI PUBL BV. - 0304-3843. ; 104:1-4, s. 281-285
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Muon spin rotation (mu SR) data on a single crystalline sample of Dy have been obtained as function of temperature and applied hydrostatic pressure. The discontinuity observed in our new data at the phase transition at 85 K strongly suggests that the muon
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2. |
- Graffner-Nordberg, Malin, et al.
(författare)
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Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues
- 2000
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 1520-4804 .- 0022-2623. ; 43:21, s. 3852-3861
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Tidskriftsartikel (refereegranskat)abstract
- The relative binding affinities to human dihydrofolate reductase of four new potential antifolates, containing ester linkages between the two aromatic systems, were estimated by free energy perturbation simulations. The ester analogue, predicted to exhibit the highest binding affinity to human dihydrofolate reductase, and a reference ester (more structurally related to methotrexate) were synthesized. As deduced from the measured IC(50) values, the calculated ranking of the ligands was correct although a greater difference in affinity was indicated by the experimental measurements. Among the new antifolates the most potent inhibitor exhibited a similar pharmacokinetic profile to methotrexate but lacked activity in a complex antiarthritic model in rat in vivo.
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4. |
- Schreier, E, et al.
(författare)
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Internal fields in magnetically ordered dysprosium, holmium and erbium
- 2000
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Ingår i: PHYSICA B. - : ELSEVIER SCIENCE BV. - 0921-4526. ; 289, s. 240-243
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Tidskriftsartikel (refereegranskat)abstract
- Muon spin rotation data on single-crystalline samples of the heavy rare earth metals Dy, Ho and Er have been obtained as function of temperature in both the antiferromagnetic (afm) and the ferromagnetic (fm) state. In the afm state the temperature depende
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