| 1. |
- Bellopede, Rossana, et al.
(författare)
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Assessment of the European Standard for the determination of resistance of marble to thermal and moisture cycles : recommendations for improvements
- 2016
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Ingår i: Environmental Earth Sciences. - : Springer Berlin/Heidelberg. - 1866-6280 .- 1866-6299. ; 75:11
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Tidskriftsartikel (refereegranskat)abstract
- The bowing phenomenon is so relevant that two projects, EU funded, from 1999 studied it and a European Standard to assess the resistance to thermal and moisture cycles (influencing bowing) has been recently adopted. In particular, according EN 16306: 2013, measurements of bowing and flexural strength should be performed before and at the end of the ageing cycles. Additional non-destructive tests are recommended, but are not compulsory for the standard. Moreover, Annex A of EN 16306 contains guidance on the limit values for the selection of marble types suitable for outdoor uses, especially façade applications. Eleven varieties of marble have been tested by means of this laboratory ageing test. Non-destructive tests such as the measurements of ultrasonic pulse velocity (UPV), adjacent grains analysis, open porosity, and water absorption have been executed together with the conventional flexural strength test. The results obtained from image analysis on thin sections indicate that the AGA index may not always be correlated with the other tests: amount of bowing, loss of flexural strength, or loss of UPV. Some consideration of the decrease in mechanical resistance and the bowing in relation to the variety of marble tested and the limit values indicated in Annex A of EN 16306 can be noted. It is known that bowing and rapid strength loss occur in some varieties of marble when used as exterior cladding and other exterior applications. Additional conclusions have been drawn: bowing and flexural strength correlate well and can be used to assess the suitability of the marble to be employed in outdoors.
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| 2. |
- Mancina, Rosellina Margherita, et al.
(författare)
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PSD3 downregulation confers protection against fatty liver disease.
- 2022
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Ingår i: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 4:1, s. 60-75
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Tidskriftsartikel (refereegranskat)abstract
- Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability component. Using a candidate gene approach, we identify a locus (rs71519934) at the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene resulting in a leucine to threonine substitution at position 186 of the protein (L186T) that reduces susceptibility to the entire spectrum of FLD in individuals at risk. PSD3 downregulation by short interfering RNA reduces intracellular lipid content in primary human hepatocytes cultured in two and three dimensions, and in human and rodent hepatoma cells. Consistent with this, Psd3 downregulation by antisense oligonucleotides in vivo protects against FLD in mice fed a non-alcoholic steatohepatitis-inducing diet. Thus, translating these results to humans, PSD3 downregulation might be a future therapeutic option for treating FLD.
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| 3. |
- Maranesi, Margherita, et al.
(författare)
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Resistin in endocrine pancreas of sheep : Presence and expression related to different diets
- 2024
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Ingår i: General and Comparative Endocrinology. - : Elsevier. - 0016-6480 .- 1095-6840. ; 348
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Tidskriftsartikel (refereegranskat)abstract
- Resistin (RETN), a recently discovered adipokine, is a cysteine-rich and secretory protein produced by adipocytes. RETN has been detected in several tissues, including human and laboratory animals' pancreas, wherein impairs glucose tolerance and insulin (INS) action and causes INS resistance. This study aims to evaluate the presence and expression of RETN in the pancreas of 15 adult female sheep reared on Apennine pastures, which show a decrease in their nutritional value due to the drought stress linked to the increasing summer aridity. The sheep were divided into 3 groups according to the diet they were subjected to: maximum pasture flowering (MxF) group, maximum pasture dryness (MxD) group, and experimental (Exp) group which received a feed supplementation in addition to the MxD group feeding. Immunohistochemistry and immunofluorescence were performed on formalin-fixed and paraffin-embedded sections of the pancreas to detect the RETN presence and to evaluate the co-localization of RETN with both glucagon (GCG)- and INS-producing cells. In addition, the expression of the three molecules was evaluated also in relation to different diets. RETN was observed only in the endocrine pancreas, showing a wide distribution throughout the pancreatic islets with few negative cells and the RETN producing cells colocalized with both alpha cells and ss cells. No differences in distribution and immunostaining intensity of RETN, GCG and INS were observed among the three groups. Quantitative PCR showed the expression of RETN, GCG and INS in all tested samples. No significant differences were observed for RETN and GCG among all three groups of sheep. Instead, a high statistically significant expression of INS was detected in the MxF group with respect to the Exp and MxD groups. These results highlight the localization of RETN in GCG- and INS-secreting cells involved in glucose homeostasis suggesting a modulatory role for RETN. Furthermore, the RETN expression is not influenced by food supplementation and thus is not affected by diet.
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| 4. |
- Neudecker, Denise, et al.
(författare)
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Templates of expected measurement uncertainties
- 2023
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Ingår i: EPJ NUCLEAR SCIENCES & TECHNOLOGIES. - : EDP Sciences. - 2491-9292. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- The covariance committee of CSEWG (Cross Section Evaluation Working Group) established templates of expected measurement uncertainties for neutron-induced total, (n,gamma), neutron-induced charged-particle, and (n,xn) reaction cross sections as well as prompt fission neutron spectra, average prompt and total fission neutron multiplicities, and fission yields. Templates provide a list of what uncertainty sources are expected for each measurement type and observable, and suggest typical ranges of these uncertainties and correlations based on a survey of experimental data, associated literature, and feedback from experimenters. Information needed to faithfully include the experimental data in the nuclear-data evaluation process is also provided. These templates could assist (a) experimenters and EXFOR compilers in delivering more complete uncertainties and measurement information relevant for evaluations of new experimental data, and (b) evaluators in achieving a more comprehensive uncertainty quantification for evaluation purposes. This effort might ultimately lead to more realistic evaluated covariances for nuclear-data applications. In this topical issue, we cover the templates coming out of this CSEWG effort-typically, one observable per paper. This paper here prefaces this topical issue by introducing the concept and mathematical framework of templates, discussing potential use cases, and giving an example of how they can be applied (estimating missing experimental uncertainties of 235U(n,f) average prompt fission neutron multiplicities), and their impact on nuclear-data evaluations.
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