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1.	Franceschini, N, et al. (author) GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes 2018 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 5141- Journal article (peer-reviewed)abstract Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
2.	Rajewsky, N, et al. (author) Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine 2021 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 592:78537852, s. E8-E8 Journal article (other academic/artistic)abstract A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03287-8.
3.	Achim, K, et al. (author) High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin 2015 In: Nature biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 33:5, s. 503-U215 Journal article (peer-reviewed)
4.	Davies, G, et al. (author) Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2068- Journal article (other academic/artistic)abstract Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
5.	de Vries, PS, et al. (author) A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels 2024 In: Blood. - 1528-0020. ; 143:18, s. 1845-1855 Journal article (peer-reviewed)
6.	Dobie, R, et al. (author) Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis 2019 In: Cell reports. - : Elsevier BV. - 2211-1247. ; 29:7, s. 1832- Journal article (peer-reviewed)
7.	Doust, C, et al. (author) Discovery of 42 genome-wide significant loci associated with dyslexia 2022 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:11, s. 1621- Journal article (peer-reviewed)abstract Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.
8.	Linner, RK, et al. (author) Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:2, s. 245- Journal article (peer-reviewed)
9.	Matchett, KP, et al. (author) Multimodal decoding of human liver regeneration 2024 In: Nature. - 1476-4687. Journal article (peer-reviewed)
10.	Pantazis, CB, et al. (author) A reference human induced pluripotent stem cell line for large-scale collaborative studies 2022 In: Cell stem cell. - : Elsevier BV. - 1875-9777 .- 1934-5909. ; 29:12, s. 1685- Journal article (peer-reviewed)

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Result 1-10 of 14

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Type of publication: journal article (14)

Type of content: peer-reviewed (11); other academic/artistic (3)

Author/Editor: Marioni, JC (7); Psaty, BM (6); Davies, G (4); Trompet, S (4); Jukema, JW (4); Rotter, JI (4); show more...; Schmidt, H. (3); Scholz, M. (3); Zhao, W. (3); Bis, JC (3); Hofer, E (3); Smith, AV (3); Teumer, A (3); Gudnason, V (3); Schmidt, R (3); Martin, NG (3); Ikram, MA (3); Liu, T. (2); Kaprio, J (2); Peters, A (2); Bennett, DA (2); Linnarsson, S (2); Fontanillas, P (2); Pedersen, NL (2); Amin, N (2); van Duijn, CM (2); Lind, Lars (2); Luciano, M (2); Wigmore, SJ (2); Koenig, W. (2); Ponting, CP (2); Seshadri, S (2); Liewald, DCM (2); Yanek, LR (2); Yang, JY (2); Amouyel, P (2); Hofman, A (2); Homuth, G (2); Montgomery, GW (2); Nalls, MA (2); Nauck, M (2); Stott, DJ (2); Tzourio, C (2); Uitterlinden, AG (2); Deary, IJ (2); Wright, MJ (2); Launer, LJ (2); Fornage, M (2); Debette, S (2); Delgado, GE (2); show less...

University: Karolinska Institutet (14); Uppsala University (3); University of Gothenburg (1); Royal Institute of Technology (1); Lund University (1); Stockholm School of Economics (1); show more...; Högskolan Dalarna (1); show less...

Language: English (14)

Research subject (UKÄ/SCB): Medical and Health Sciences (4); Natural sciences (1)

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