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| 2. |
- Mayes, Maureen D, et al.
(författare)
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Immunochip analysis identifies multiple susceptibility Loci for systemic sclerosis.
- 2014
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 94:1, s. 47-61
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Tidskriftsartikel (refereegranskat)abstract
- In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested. These analyses resulted in a model composed of six polymorphic amino acid positions and seven SNPs that explained the observed significant associations in the region. In addition, a replication step comprising 4,017 SSc cases and 5,935 controls was carried out for several selected non-HLA variants, reaching a total of 5,850 cases and 9,401 controls of European ancestry. Following this strategy, we identified and validated three SSc risk loci, including DNASE1L3 at 3p14, the SCHIP1-IL12A locus at 3q25, and ATG5 at 6q21, as well as a suggested association of the TREH-DDX6 locus at 11q23. The associations of several previously reported SSc risk loci were validated and further refined, and the observed peak of association in PXK was related to DNASE1L3. Our study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci.
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| 3. |
- Lindwall, Magnus, et al.
(författare)
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Approaching a broadened view on behavioral regulation in exercise : A closer look at different facets of introjected regulation using the revised BREQ-4
- 2019
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Ingår i: Abstract Book.
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Konferensbidrag (refereegranskat)abstract
- Identifying different types of motivation that regulate behavior in an exercise context has been of high interest in exercise psychology science. One of the most widely used instruments for this purpose is the Behavioural Regulation in Exercise Questionnaire-2 (BREQ-2; Markland & Tobin, 2004), which recently has been revised (BREQ-3, Cid et al., 2018) to include also integrated regulation. In previous work, questions have been raised about the nature of introjected regulation, suggesting it can be divided into two different types of regulations, mirroring avoidance and approach. Therefore, BREQ-3 has been further revised to include items that measure: two facets of introjected regulation (approach and avoidance), resulting in a 28-item instrument (named BREQ-4) measuring seven types of exercise regulation.The purpose of this paper is to examine: (i) the factorial structure of the new and revised instrument BREQ-4; and (ii) associations between the two newly developed facets of introjected regulation (approach and avoidance), exercise behavior and the other types of regulation in the context of exercise.Two subsamples, one from the UK consisting of 412 younger (mean age: 21.6 years) adults recruited from various Facebook groups, and one from Sweden, consisting of 369 middle aged (mean age: 40.7) working individuals, also recruited via Facebook, were used. In both samples, data was collected online through Qualtrics. Structural equation modeling was used to examine factorial validity and associations between latent constructs of exercise regulation in BREQ-4 and self-reported exercise behavior.Confirmatory factor analysis revealed that the 28-item 7-factor model displayed acceptable fit to data in both samples. Configural and metric invariance, but not scalar invariance, between the two samples was established. Avoidance regulation was unrelated to exercise behavior in both samples, whereas approach regulation was weakly and positively associated with exercise in the UK sample. Avoidance and approach was moderately to strongly associated in both samples. In terms of patterns of associations with the other types of regulations, results were similar in both samples: avoidance was more strongly associated with extrinsic regulation whereas approach was more robustly associated with self-determined types of motivation (identified, integrated and intrinsic motivation).
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| 4. |
- Lindwall, Magnus, 1975, et al.
(författare)
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Stirring the motivational soup: withinperson latent profiles of motivation in exercise
- 2017
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Ingår i: International Journal of Behavioral Nutrition and Physical Activity. - London : Springer Science and Business Media LLC. - 1479-5868. ; 14:4, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- Background: The purpose of the present study was to use a person-oriented analytical approach to identify latent motivational profiles, based on the different behavioural regulations for exercise, and to examine differences in satisfaction of basic psychological needs (competence, autonomy and relatedness) and exercise behaviour across these motivational profiles. Methods: Two samples, consisting of 1084 and 511 adults respectively, completed exercise-related measures of behavioural regulation and psychological need satisfaction as well as exercise behaviour. Latent profile analyses were used to identify motivational profiles. Results: Six profiles, representing different combinations of regulations for exercise, were found to best represent data in both samples. Some profiles were found in both samples (e.g., low motivation profile, self-determined motivation profile and self-determined with high introjected regulation profile), whereas others were unique to each sample. In line with the Self-Determination Theory, individuals belonging to more self-determined profiles demonstrated higher scores on need satisfaction. Conclusions: The results support the notions of motivation being a multidimensional construct and that people have different, sometimes competing, reasons for engaging in exercise. The benefits of using person-oriented analyses to examine within-person interactions of motivation and different regulations are discussed.
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| 5. |
- Teixeira, Pedro J., et al.
(författare)
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Classification of Techniques Used in Self-Determinationheory-Based Interventions in Health Contexts : An Expert Consensus Study
- 2020
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Ingår i: Motivation Science. - Washington, DC : American Psychological Association (APA). - 2333-8113 .- 2333-8121. ; 6:4, s. 438-445
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Tidskriftsartikel (refereegranskat)abstract
- While evidence suggests that interventions based on self-determination theory can be effective in motivating adoption and maintenance of health-related behaviors, and in promoting adaptive psychological outcomes, the motivational techniques that comprise the content of these interventions have not been comprehensively identified or described. The aim of the present study was to develop a classification system of the techniques that comprise self-determination theory interventions, with satisfaction of psychological needs as an organizing principle. Candidate techniques were identified through a comprehensive review of self-determination theory interventions and nomination by experts. The study team developed a preliminary list of candidate techniques accompanied by labels, definitions, and function descriptions of each. Each technique was aligned with the most closely-related psychological need satisfaction construct (autonomy, competence, or relatedness). Using an iterative expert consensus procedure, participating experts (N = 18) judged each technique on the preliminary list for redundancy, essentiality, uniqueness, and the proposed link between the technique and basic psychological need. The procedure produced a final classification of 21 motivation and behavior change techniques (MBCTs). Redundancies between final MBCTs against techniques from existing behavior change technique taxonomies were also checked. The classification system is the first formal attempt to systematize self-determination theory intervention techniques. The classification is expected to enhance consistency in descriptions of self-determination theory-based interventions in health contexts, and assist in facilitating synthesis of evidence on interventions based on the theory. The classification is also expected to guide future efforts to identify, describe, and classify the techniques that comprise self-determination theory-based interventions in multiple domains. © 2020, American Psychological Association.
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