| 1. |
- Bruze, Magnus, et al.
(författare)
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Contact allergy to oxidised geraniol may be over-represented in individuals with photocontact allergy to ketoprofen
- 2024
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Ingår i: Contact Dermatitis. - 0105-1873. ; 90:1, s. 79-83
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Tidskriftsartikel (refereegranskat)abstract
- Background: Simultaneous overrepresentations of contact allergies and photocontact allergies are common in individuals with photocontact allergy to ketoprofen. Aims: To investigate whether contact allergy to oxidised (ox.) geraniol, geraniol, geranial, neral and citral is overrepresented in individuals with photocontact allergy to ketoprofen. Methods: The contact allergy rates to ox. geraniol, geraniol, geranial, neral and citral in routinely patch tested dermatitis patients were compared with the corresponding rates in individuals with photocontact allergy to ketoprofen. Results: Allergic patch test reactions were noted to ox. geraniol 11% (n = 39, 5.8%), ox. geraniol 6% (n = 12, 1.8%), geraniol 6% (n = 2, 0.3%), geranial (n = 18, 2.7%), neral (n = 7, 1.0%) and citral (n = 15, 2.2%). In those four patients who were diagnosed with photocontact allergy to ketoprofen during the test period, a significant overrepresentation (p = 0.020) of simultaneous contact allergy to ox. geraniol 11% was demonstrated. Overrepresentation of simultaneous contact allergy to various combinations of ox. geraniol, ox. limonene and ox. linalool was also noted in ketoprofen-photoallergic patients. Conclusions: Contact allergy to ox. geraniol, geranial and citral is common in routinely tested dermatitis patients. There is an overrepresentation of simultaneous contact allergy to ox. geraniol, ox. limonene and ox. linalool in patients with photocontact allergy to ketoprofen.
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| 2. |
- Bruze, Magnus, et al.
(författare)
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Contact Allergy to Oxidized Linalool and Oxidized Limonene is Over-represented in Individuals with Photocontact Allergy to Ketoprofen
- 2021
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 1651-2057. ; 101:5
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Tidskriftsartikel (refereegranskat)abstract
- Simultaneous contact allergies are common in individuals with photocontact allergy to ketoprofen. The rate of contact allergy to the fragrance substances oxidized linalool and oxidized limonene in ketoprofen-photo-allergic individuals were investigated in comparison with the corresponding rates in individuals without photo-contact allergy to ketoprofen, using Fisher's exact test. A total of 4,021 patients were routinely tested with oxidized linalool; of whom 190 (4.7%) tested positively. For oxidized limonene the numbers were 3,797 patients and 111 positive reactions (2.9%). A total of 19 contact allergic reactions to oxidized linalool were noted in 29 patients (65.5%) who also had photocontact allergy to ketoprofen (p < 0.0001). The corresponding figures for oxidized limonene were 10 positive reactions in 24 ketoprofen-photoallergic individuals (41.7%) (p < 0.0001). Contact allergy to oxidized linalool and/or oxidized limonene is common in routinely tested patients with dermatitis and, particularly, in those patients who are photoallergic to ketoprofen.
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| 3. |
- Marmgren, Victoria, et al.
(författare)
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Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen
- 2021
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 85:6, s. 660-670
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Contact allergy to fragrance mix I (FM I) is over-represented in patients photoallergic to ketoprofen. The prevalence of contact allergy to two components of FM I, cinnamal and cinnamyl alcohol, in ketoprofen-photoallergic patients is higher than in dermatitis patients.OBJECTIVE: To explore the prevalence of contact allergy to FM I and its individual components in patients with photocontact allergy to ketoprofen, and to compare with a dermatitis and the general population.METHODS: Data on patch and photopatch tests performed between 2009-2018 were collected. Ketoprofen-photoallergic patients were compared with dermatitis patients and published data on the general population regarding the prevalence and the distribution of contact allergy to FM I and its components.RESULTS: A higher prevalence of contact allergy to cinnamyl alcohol compared to cinnamal (23.3% vs 10.0%), and eugenol compared to isoeugenol (23.3% vs 6.7%), was observed in ketoprofen-photoallergic patients, while the relationship was the opposite in dermatitis group (0.7% vs 1.05%; 0.4% vs 0.9%). Overall prevalence of contact allergy to several components of FM I was significantly higher in ketoprofen-photoallergic patients.CONCLUSIONS: Contact allergy to FM I and many of its components is over-represented in patients photoallergic to ketoprofen compared to dermatitis patients and the general population. This article is protected by copyright. All rights reserved.
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| 4. |
- Marmgren, Victoria
(författare)
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Photocontact Allergy to Ketoprofen and Simultaneous Contact Allergies
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Ketoprofen is a non-steroidal anti-inflammatory drug with analgesic, antipyretic, and anti-inflammatory properties. It is available in both oral and topical formulations. Photocontact allergy to topically applied ketoprofen has been the most frequent side effect of the formulation, and is fairly well studied. The risk of development of photocontact allergy and of persistent photosensitivity as the result of photosensitization has led to warnings and restricted distribution of ketoprofen-containing gels. Apart from the risk of developing a photoallergic contact dermatitis upon repeated exposure to ketoprofen, the sensitized individuals show higher rates of photocontact and contact allergy to some other sensitizers. Simultaneous photocontact allergic reactions to benzophenones, fentichlor, chlorpromazine, bithionol, tetrachlorosalicylanilide and promethazine were described in patients with photocontact allergy to ketoprofen in the middle of 2000s. Similarly, an overrepresentation of contact allergy to fragrance mix I and Myroxylon pereirae in the same group has been known for decades. There is no known common mechanism of simultaneous photocontact and contact allergy, but several research groups have suggested the possibility of cross-reactivity between ketoprofen, which is a substituted benzophenone, and other chemicals with a benzophenone moiety.This thesis forms a part of the search for an explanation of the phenomenon of simultaneous contact allergies in individuals with photocontact allergy to ketoprofen. A broad perspective is essential in order to understand any phenomenon, which in this case means that we need to obtain better knowledge of which sensitizers individuals with photocontact allergy to ketoprofen may react to more often compared to controls.Study I examined the possibility of simplifying the procedure of photopatch testing with ketoprofen, and found that reliable results can be obtained by shortening the occlusion time from 24 hours to 1 hour, with no need to change other parameters such as concentration or UVA dose. Studies II, III, and IV were concerned with the epidemiology of simultaneous contact allergy in patients with photocontact allergy to ketoprofen. Study II revealed that patch testing with some of the individual components of fragrance mix I (cinnamal, cinnamyl alcohol, eugenol, and isoeugenol) produced significantly higher numbers of positive patch test reactions in those with photocontact allergy to ketoprofen compared to controls. Similarly, Study IV found that a number of sensitizers tested within the baseline series led to significantly higher rates of contact allergy in those with photocontact allergy to ketoprofen than in dermatitis patients and in the general population. Study III confirmed a clinical suspicion that contact allergy to oxidized linalool and oxidized limonene was indeed overrepresented in the ketoprofen group.The clinical relevance of these findings is yet to be investigated, but this thesis discusses some of the hypotheses proposed by various researchers in order to explain the phenomenon of simultaneous contact allergies that arise in connection with photosensitization to ketoprofen. Although no definite explanation can be given to date, the main goal of this research is to gain a better understanding of the epidemiology of simultaneous contact allergy, which can act as a building block in future research.
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| 5. |
- Marmgren, Victoria, et al.
(författare)
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Successful Photopatch Testing with Ketoprofen Using One-Hour Occlusion.
- 2011
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 1651-2057 .- 0001-5555. ; 91, s. 131-136
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Tidskriftsartikel (refereegranskat)abstract
- The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen. A total of 22 patients with a known or suspected photo-allergy to ketoprofen were simultaneously photopatch-tested with ketoprofen using both 1 h and 24 h occlusion. One side of the patient's back was irradiated with 5 J/cm2 UVA, and the other side was covered. Measurements were made after 3 days on both irradiated and non-irradiated sides. A total of 20 controls were photopatch-tested with ketoprofen using 1 h occlusion. All of the patients showed positive reactions on the irradiated side. No positive reactions were observed on the non-irradiated side. All controls were negative. In conclusion, 1 h occlusion time is sufficient to establish photo-contact allergy to ketoprofen. No adjustments in UVA or ketoprofen dose were needed. Limiting occlu-sion time to 1 h could simplify the photopatch test procedure by eliminating one visit to the clinic. These results apply only to ketoprofen; further studies are needed to determine whether a similar approach can be used with other components of photopatch test series.
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