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- Cruz, Raquel, et al.
(författare)
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Novel genes and sex differences in COVID-19 severity
- 2022
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:22, s. 3789-3806
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Tidskriftsartikel (refereegranskat)abstract
- Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
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- Sánchez Alcón, José A, et al.
(författare)
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Automated determination of security services to ensure personal data protection in the Internet of Things applications
- 2013
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Ingår i: IEEE Third international conference on Innovative Computing Technology - INTECH 2013. - 9781479900473 ; , s. 71-76
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Konferensbidrag (refereegranskat)abstract
- This paper describes a method aimed at automatically determining security services to be implementedin products, services and devices involved on the Internet of Things scenarios. It is important toconsider the specific context, legislative diversity and nature of the information since its main objective is to have correct and fair data processing that avoids users in perceiving any danger to their privacy. This paper gives a brief overview based on several types of security threat scenarios. It tries tointroduce “Utility Matrix” concept that connects involved users, their security needs, and legal imperatives all together. Based on “Utility Matrix”, an expert system is proposed in order to automatesecurity service decisions and solution for personal data protection on the area of Internet of Things. Different approaches are presented, and several applied use cases are given for AWARE product, such as application. This automated system is in the development phase. Nevertheless, this project has toconnect areas of the Industry to the judicial and technology, taking into account that users are in themiddle of the scenario. As a result of this project, a certificate of personal data protection to users and companies could be obtained. It could be a tool to simulate and evaluate the impact of new services, new laws, and new needs in technology and research.
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| 9. |
- Castillejo, Pedro, et al.
(författare)
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An Internet of Things approach for managing smart services provided by wearable devices
- 2013
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Ingår i: International Journal of Distributed Sensor Networks. - : Hindawi Publishing Corporation. - 1550-1329 .- 1550-1477. ; 2013, s. Article number 190813-
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Tidskriftsartikel (refereegranskat)abstract
- The Internet of Things (IoT) is growing at a fast pace with new devices getting connected all the time. A new emerging group of these devices is the wearable devices, and the wireless sensor networks are a good way to integrate them in the IoT concept and bring new experiences to the daily life activities. In this paper, we present an everyday life application involving a WSN as the base of a novel context-awareness sports scenario, where physiological parameters are measured and sent to the WSN by wearable devices. Applications with several hardware components introduce the problem of heterogeneity in the network. In order to integrate different hardware platforms and to introduce a service-oriented semantic middleware solution into a single application, we propose the use of an enterprise service bus (ESB) as a bridge for guaranteeing interoperability and integration of the different environments, thus introducing a semantic added value needed in the world of IoT-based systems. This approach places all the data acquired (e.g., via internet data access) at application developers disposal, opening the system to new user applications. The user can then access the data through a wide variety of devices (smartphones, tablets, and computers) and operating systems (Android, iOS, Windows, Linux, etc.).
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| 10. |
- Castillejo, Pedro, et al.
(författare)
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Integration of wearable devices in a wireless sensor network for an E-health application
- 2013
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Ingår i: IEEE wireless communications. - 1536-1284 .- 1558-0687. ; 20:4, s. 38-49
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Tidskriftsartikel (refereegranskat)abstract
- Applications based on Wireless Sensor Networks for Internet of Things scenarios are on the rise. The multiple possibilities they offer have spread towards previously hard to imagine fields, like e-health or human physiological monitoring. An application has been developed for its usage in scenarios where data collection is applied to smart spaces, aiming at its usage in fire fighting and sports. This application has been tested in a gymnasium with real, non-simulated nodes and devices. A Graphic User Interface has been implemented to suggest a series of exercises to improve a sportsman/woman s condition, depending on the context and their profile. This system can be adapted to a wide variety of e-health applications with minimum changes, and the user will interact using different devices, like smart phones, smart watches and/or tablets.
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