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| 2. |
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| 3. |
- Korenblik, R., et al.
(författare)
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Dragon 1 Protocol Manuscript : Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy
- 2022
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Ingår i: Cardiovascular and Interventional Radiology. - : Springer. - 0174-1551 .- 1432-086X. ; 45, s. 1391-1398
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Tidskriftsartikel (refereegranskat)abstract
- Study Purpose The DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) to accelerate future liver remnant (FLR) hypertrophy in patients with borderline resectable colorectal cancer liver metastases. Methods The DRAGON 1 trial is a worldwide multicenter prospective single arm trial. The primary endpoint is a composite of the safety of PVE/HVE, 90-day mortality, and one year accrual monitoring of each participating center. Secondary endpoints include: feasibility of resection, the used PVE and HVE techniques, FLR-hypertrophy, liver function (subset of centers), overall survival, and disease-free survival. All complications after the PVE/HVE procedure are documented. Liver volumes will be measured at week 1 and if applicable at week 3 and 6 after PVE/HVE and follow-up visits will be held at 1, 3, 6, and 12 months after the resection. Results Not applicable. Conclusion DRAGON 1 is a prospective trial to assess the safety and feasibility of PVE/HVE. Participating study centers will be trained, and procedures standardized using Work Instructions (WI) to prepare for the DRAGON 2 randomized controlled trial. Outcomes should reveal the accrual potential of centers, safety profile of combined PVE/HVE and the effect of FLR-hypertrophy induction by PVE/HVE in patients with CRLM and a small FLR.
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| 4. |
- Borge, M. J. G., et al.
(författare)
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Asymmetry in the super-allowed beta-transitions of the A=9 isobars
- 2004
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Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 738:1-4 SUPPL., s. 206-210
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Tidskriftsartikel (refereegranskat)abstract
- We report here on the recent beta-decay studies of the A = 9 isobar made at ISOLDE/CERN. Mirror beta transitions in the A=9 chain are compared and a large asymmetry factor is deduced for the transitions to high excitation energy in Be-9 (11.8 MeV) and B-9 (12.2 MeV) fed in the beta-decay of Li-9 and C-9 respectively. It is shown that the asymmetry is not due to experimental problems or differences in the mechanisms of breakup or in the spin of the states. Only differences in the partial decay branches of the breakup channels have been found. As no asymmetry is found in the gs to gs transition it must be due to the particular structure of these excited states.
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| 5. |
- Deschasaux, M., et al.
(författare)
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Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study
- 2018
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Ingår i: Plos Medicine. - : Public Library of Science (PLoS). - 1549-1676 .- 1549-1277. ; 15:9
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Tidskriftsartikel (refereegranskat)abstract
- Background Helping consumers make healthier food choices is a key issue for the prevention of cancer and other diseases. In many countries, political authorities are considering the implementation of a simplified labelling system to reflect the nutritional quality of food products. The Nutri-Score, a five-colour nutrition label, is derived from the Nutrient Profiling System of the British Food Standards Agency (modified version) (FSAm-NPS). How the consumption of foods with high/low FSAm-NPS relates to cancer risk has been studied in national/regional cohorts but has not been characterized in diverse European populations. This prospective analysis included 471,495 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC, 1992-2014, median follow-up: 15.3 y), among whom there were 49,794 incident cancer cases (main locations: breast, n = 12,063; prostate, n = 6,745; colon-rectum, n = 5,806). Usual food intakes were assessed with standardized country-specific diet assessment methods. The FSAm-NPS was calculated for each food/beverage using their 100-g content in energy, sugar, saturated fatty acid, sodium, fibres, proteins, and fruits/vegetables/legumes/nuts. The FSAm-NPS scores of all food items usually consumed by a participant were averaged to obtain the individual FSAm-NPS Dietary Index (DI) scores. Multi-adjusted Cox proportional hazards models were computed. A higher FSAm-NPS DI score, reflecting a lower nutritional quality of the food consumed, was associated with a higher risk of total cancer (HRQ5 versus (Q1) = 1.07; 95% CI 1.03-1.10, P-trend < 0.001). Absolute cancer rates in those with high and low (quintiles 5 and 1) FSAm-NPS DI scores were 81.4 and 69.5 cases/10,000 person-years, respectively. Higher FSAm-NPS DI scores were specifically associated with higher risks of cancers of the colon-rectum, upper aerodigestive tract and stomach, lung for men, and liver and postmenopausal breast for women (all P < 0.05). The main study limitation is that it was based on an observational cohort using self-reported dietary data obtained through a single baseline food frequency questionnaire; thus, exposure misclassification and residual confounding cannot be ruled out. In this large multinational European cohort, the consumption of food products with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher risk of cancer. This supports the relevance of the FSAm-NPS as underlying nutrient profiling system for front-of-pack nutrition labels, as well as for other public health nutritional measures.
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| 6. |
- Grigorenko,, et al.
(författare)
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Deep excursion beyond the proton dripline. II. Toward the limits of existence of nuclear structure
- 2018
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 98:6
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Tidskriftsartikel (refereegranskat)abstract
- Prospects of experimental studies of argon and chlorine isotopes located far beyond the proton dripline are studied by using systematics and cluster models. The deviations from the widespread systematics observed in Cl-28,Cl-29 and Ar-29,Ar-30 have been theoretically substantiated, and analogous deviations have been predicted for the lighter chlorine and argon isotopes. The limits of nuclear structure existence are predicted for Ar and Cl isotopic chains, with Ar-26 and Cl-25 found to be the lightest sufficiently long-living nuclear systems. By simultaneous measurements of protons and gamma rays following decays of such systems as well as their beta-delayed emission, an interesting synergy effect may be achieved, which is demonstrated by the example of Cl-30 and Ar-31 ground-state studies. Such a synergy effect may be provided by the new EXPERT setup (EXotic Particle Emission and Radioactivity by Tracking) being operated inside the fragment separator and spectrometer facility at GSI, Darmstadt.
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| 7. |
- Kostyleva, D., et al.
(författare)
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Towards the Limits of Existence of Nuclear Structure: Observation and First Spectroscopy of the Isotope K-31 by Measuring Its Three-Proton Decay
- 2019
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 123:9
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Tidskriftsartikel (refereegranskat)abstract
- The most remote isotope from the proton dripline (by 4 atomic mass units) has been observed: K-31. It is unbound with respect to three-proton (3p) emission, and its decays have been detected in flight by measuring the trajectories of all decay products using microstrip detectors. The 3p emission processes have been studied by the means of angular correlations of S-28 + 3p and the respective decay vertices. The energies of the previously unknown ground and excited states of K-31 have been determined. This provides its 3p separation energy value S-3p of -4.6(2) MeV. Upper half-life limits of 10 ps of the observed K-31 states have been derived from distributions of the measured decay vertices.
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| 8. |
- Mukha, I. G., et al.
(författare)
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Deep excursion beyond the proton dripline. I. Argon and chlorine isotope chains
- 2018
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Ingår i: Physical Review C. - 2469-9993 .- 2469-9985. ; 98:6
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Tidskriftsartikel (refereegranskat)abstract
- The proton-unbound argon and chlorine isotopes have been studied by measuring trajectories of their decay-in-flight products by using a tracking technique with microstrip detectors. The proton (1p) and two-proton (2p) emission processes have been detected in the measured angular correlations "heavy-fragment"+p and "heavy-fragment"+p+p, respectively. The ground states of the previously unknown isotopes Cl30 and Cl28 have been observed for the first time, providing the 1p-separation energies Sp of -0.48(2) and -1.60(8), MeV, respectively. The relevant systematics of 1p- and 2p-separation energies have been studied theoretically in the core+p and core+p+p cluster models. The first-time observed excited states of Ar31 allow one to infer the 2p-separation energy S2p of 6(34) keV for its ground state. The first-time observed state in Ar29 with S2p=-5.50(18) MeV can be identified as either a ground state or an excited state according to different systematics.
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| 9. |
- Mukha, I., et al.
(författare)
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Observation and Spectroscopy of New Proton-Unbound Isotopes Ar-30 and Cl-29: An Interplay of Prompt Two-Proton and Sequential Decay
- 2015
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 115:20, s. 7-
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Tidskriftsartikel (refereegranskat)abstract
- Previously unknown isotopes Ar-30 and Cl-29 have been identified by measurement of the trajectories of their in-flight decay products S-28 + p + p and S-28 + p, respectively. The analysis of angular correlations of the fragments provided information on decay energies and the structure of the parent states. The ground states of Ar-30 and Cl-29 were found at 2.25(-0.10)(+0.15) and 1.8 +/- 0.1 MeV above the two-and one-proton thresholds, respectively. The lowest states in Ar-30 and Cl-29 point to a violation of isobaric symmetry in the structure of these unbound nuclei. The two-proton decay has been identified in a transition region between simultaneous two-proton and sequential proton emissions from the Ar-30 ground state, which is characterized by an interplay of three-body and two-body decay mechanisms. The first hint of a fine structure of the two-proton decay of Ar-30*(2(+)) has been obtained by detecting two decay branches into the ground and first-excited states of the S-28 fragment.
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| 10. |
- Rousseau-Nepton, L., et al.
(författare)
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SIGNALS : I. Survey description
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 489:4, s. 5530-5546
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Tidskriftsartikel (refereegranskat)abstract
- SIGNALS, the Star formation, Ionized Gas, and Nebular Abundances Legacy Survey, is a large observing programme designed to investigate massive star formation and HII regions in a sample of local extended galaxies. The programme will use the imaging Fourier transform spectrograph SITELLE at the Canada-France-Hawaii Telescope. Over 355 h (54.7 nights) have been allocated beginning in fall 2018 for eight consecutive semesters. Once completed, SIGNALS will provide a statistically reliable laboratory to investigate massive star formation, including over 50 000 resolved HII regions: the largest, most complete, and homogeneous data base of spectroscopically and spatially resolved extragalactic HII regions ever assembled. For each field observed, three datacubes covering the spectral bands of the filters SN1 (363386 nm), SN2 (482-513 nm), and SN3 (647-685 nm) are gathered. The spectral resolution selected for each spectral band is 1000, 1000, and 5000, respectively. As defined, the project sample will facilitate the study of small-scale nebular physics and many other phenomena linked to star formation at a mean spatial resolution of similar to 20 pc. This survey also has considerable legacy value for additional topics, including planetary nebulae, diffuse ionized gas, and supernova remnants. The purpose of this paper is to present a general outlook of the survey, notably the observing strategy, galaxy sample, and science requirements.
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