| 1. |
- Alleva, Jessica M., et al.
(författare)
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What can my body do vs. how does it look?: A qualitative analysis of young women and men's descriptions of their body functionality or physical appearance
- 2019
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Ingår i: Body Image. - : Elsevier BV. - 1740-1445. ; 31, s. 71-80
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to explore the themes that emerge when individuals are asked to describe their body functionality, and those that emerge when individuals are asked to describe their physical appearance. Data were gathered from undergraduate women and men's (N = 75, Mage = 20.66) responses to a writing exercise (Alleva et al., 2014), wherein they were either asked to describe their body functionality or their physical appearance. Through thematic analysis, six themes were identified from participants’ descriptions of their body functionality (ordered by frequency): (a) evaluating the functionality of the body, (b) positive body-self connection, (c) resilient body, (d) comparisons to the norm, (e) body behind the scenes, and (f) enjoyment of body functions. Five themes were identified from participants’ descriptions of their physical appearance (ordered by frequency): (a) comparisons to the norm, (b) evaluating the appearance of the body – own evaluations, (c) evaluating the appearance of the body – other people's evaluations, (d) the body project, and (e) appearance appreciation. Overall, the findings suggest that the themes that emerge when people are asked to reflect on their body functionality tend to be more positive, as they can be linked to positive embodiment, gratitude, and less self-objectification.
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| 2. |
- Hagger, Martin S., et al.
(författare)
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A Multilab Preregistered Replication of the Ego-Depletion Effect
- 2016
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Ingår i: Perspectives on Psychological Science. - : Sage Publications. - 1745-6916 .- 1745-6924. ; 11:4, s. 546-573
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Tidskriftsartikel (refereegranskat)abstract
- Good self-control has been linked to adaptive outcomes such as better health, cohesive personal relationships, success in the workplace and at school, and less susceptibility to crime and addictions. In contrast, self-control failure is linked to maladaptive outcomes. Understanding the mechanisms by which self-control predicts behavior may assist in promoting better regulation and outcomes. A popular approach to understanding self-control is the strength or resource depletion model. Self-control is conceptualized as a limited resource that becomes depleted after a period of exertion resulting in self-control failure. The model has typically been tested using a sequential-task experimental paradigm, in which people completing an initial self-control task have reduced self-control capacity and poorer performance on a subsequent task, a state known as ego depletion. Although a meta-analysis of ego-depletion experiments found a medium-sized effect, subsequent meta-analyses have questioned the size and existence of the effect and identified instances of possible bias. The analyses served as a catalyst for the current Registered Replication Report of the ego-depletion effect. Multiple laboratories (k = 23, total N = 2,141) conducted replications of a standardized ego-depletion protocol based on a sequential-task paradigm by Sripada et al. Meta-analysis of the studies revealed that the size of the ego-depletion effect was small with 95% confidence intervals (CIs) that encompassed zero (d = 0.04, 95% CI [-0.07, 0.15]. We discuss implications of the findings for the ego-depletion effect and the resource depletion model of self-control.
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| 3. |
- Schophuizen, Carolien M. S., et al.
(författare)
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Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter
- 2013
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Ingår i: Pflügers Archiv. - : Springer Science and Business Media LLC. - 0031-6768. ; 465:12, s. 1701-1714
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Tidskriftsartikel (refereegranskat)abstract
- Several organic cations, such as guanidino compounds and polyamines, have been found to accumulate in plasma of patients with kidney failure due to inadequate renal clearance. Here, we studied the interaction of cationic uremic toxins with renal organic cation transport in a conditionally immortalized human proximal tubule epithelial cell line (ciPTEC). Transporter activity was measured and validated in cell suspensions by studying uptake of the fluorescent substrate 4-(4-(dimethylamino)styryl)-N-methylpyridinium-iodide (ASP(+)). Subsequently, the inhibitory potencies of the cationic uremic toxins, cadaverine, putrescine, spermine and spermidine (polyamines), acrolein (polyamine breakdown product), guanidine, and methylguanidine (guanidino compounds) were determined. Concentration-dependent inhibition of ASP(+) uptake by TPA, cimetidine, quinidine, and metformin confirmed functional endogenous organic cation transporter 2 (OCT2) expression in ciPTEC. All uremic toxins tested inhibited ASP(+) uptake, of which acrolein required the lowest concentration to provoke a half-maximal inhibition (IC50 = 44 +/- 2 mu M). A Dixon plot was constructed for acrolein using three independent inhibition curves with 10, 20, or 30 mu M ASP(+), which demonstrated competitive or mixed type of interaction (K (i) = 93 +/- 16 mu M). Exposing the cells to a mixture of cationic uremic toxins resulted in a more potent and biphasic inhibitory response curve, indicating complex interactions between the toxins and ASP(+) uptake. In conclusion, ciPTEC proves a suitable model to study cationic xenobiotic interactions. Inhibition of cellular uptake transport was demonstrated for several uremic toxins, which might indicate a possible role in kidney disease progression during uremia.
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