| 1. |
- Jeon, Il, et al.
(författare)
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Lithium-Ion Endohedral Fullerene (Li+@C-60) Dopants in Stable Perovskite Solar Cells Induce Instant Doping and Anti-Oxidation
- 2018
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 57:17, s. 4607-4611
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Tidskriftsartikel (refereegranskat)abstract
- Herein, we report use of [Li+@C-60]TFSI- as a dopant for spiro-MeOTAD in lead halide perovskite solar cells. This approach gave an air stability nearly 10-fold that of conventional devices using Li+TFSI-. Such high stability is attributed to the hydrophobic nature of [Li+@C-60]TFSI- repelling moisture and absorbing intruding oxygen, thereby protecting the perovskite device from degradation. Furthermore, [Li+@C-60]TFSI- could oxidize spiro-MeOTAD without the need for oxygen. The encapsulated devices exhibited outstanding air stability for more than 1000h while illuminated under ambient conditions.
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| 2. |
- Arai, Kaori, et al.
(författare)
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Subjectivity of the Ainu People Described in the Book ‘Nibutani’, Edited by Kaizawa Tadashi : A New Discovery and Approach to Ainu Research
- 2014
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Ingår i: Re: Mindings. - Uppsala : The Hugo Valentin Centre, Uppsala University. - 9789186531102 ; , s. 17-25
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Bokkapitel (refereegranskat)abstract
- Ainu studies still lack an inside perspective from the Ainu themselves though the importance of such perspective has been recognized for a deeper understanding of the Ainu by a few Ainu and Wajin [ethnic Japanese] postmodern scholar. To begin with, Ainu “self telling history” have been considered by researchers of Ainu studies to be “non-existent.” In other words, it can be said that the very act of dealing with modern history in relation to the Ainu by those materials was under a taboo for both the Ainu and the Wajin.This article demonstrates that a history book of the Nibutani Community entitled “Nibutani” edited by Kaizawa Tadashi in cooperation with local residents is a rare ex- ample of modern Ainu history compiled by the Ainu themselves. The book covers all the details of each family with family trees though the Ainu hardly confessed them- selves as Ainu under severe discrimination at the time. Further most of its lifestories were collected through the interviewing of those families by Kaizawa himself. As far as the contents are concerned, some stories are related to the Ainu, whereas others are seemingly related to their personal life. Thus the book presented a variety of stories that represent the then lives of the local residents in the Nibutani Community.At the moment when ‘Nibutani’ was published the Ainu did not voluntari- ly talk about their own history, and neither were expected to do so. ‘Nibutani’, which was completed by Kaizawa, connected the individually divided histories to each other, and made clear the relationships between the individuals and the community. As a result, the local residents in the Nibutani Community have ap- preciated this book for highlighting their own perspectives on their local history.
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| 3. |
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| 4. |
- Dong, Jiao, et al.
(författare)
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Dental pulp stem cell-derived small extracellular vesicle in irradiation-induced senescence
- 2021
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Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 0006-291X. ; 575, s. 28-35
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Tidskriftsartikel (refereegranskat)abstract
- Small extracellular vesicles (sEV) facilitate signaling molecule transfer among cells. We examined the therapeutic efficacy of human dental pulp stem cell-derived sEV (hDPSC-sEV) against cellular senescence in an irradiated-submandibular gland mouse model. Seven-week-old mice were exposed to 25 Gy radiation and randomly assigned to control, phosphate-buffered saline (PBS), or hDPSC-sEV groups. At 18 days post-irradiation, saliva production was measured; histological and reverse transcription-quantitative PCR analyses of the submandibular glands were performed. The salivary flow rate did not differ significantly between the PBS and hDPSC-sEV groups. AQP5-expressing acinar cell numbers and AQP5 expression levels in the submandibular glands were higher in the hDPSC-sEV group than in the other groups. Furthermore, compared with non-irradiated mice, mice in the 25 Gy + PBS group showed a high senescence-associated-β-galactosidase-positive cell number and upregulated senescence-related gene (p16INK4a, p19Arf, p21) and senescence-associated secretory phenotypic factor (MMP3, IL-6, PAI-1, NF-κB, and TGF-β) expression, all of which were downregulated in the hDPSC-sEV group. Superoxide dismutase levels were lower in the PBS group than in the hDPSC-sEV group. In summary, hDPSC-sEV reduced inflammatory cytokine and senescence-related gene expression and reversed oxidative stress in submandibular cells, thereby preventing irradiation-induced cellular senescence. Based on these results, we hope to contribute to the development of innovative treatment methods for salivary gland dysfunction that develops after radiotherapy for head and neck cancer.
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| 5. |
- Liu, Kehong, et al.
(författare)
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Conditioned medium of human mesenchymal stem cells affects stem cell senescence in osteoporosis
- 2024
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Ingår i: Biochemical and Biophysical Research Communications. - 0006-291X. ; 711
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Tidskriftsartikel (refereegranskat)abstract
- Systemic transplantation of mesenchymal stem cells (MSCs) and conditioned medium derived from MSCs have been reported to recover bone loss in animal models of osteoporosis; however, the underlying mechanisms remain unclear. We recently reported that extracellular vesicles released from human mesenchymal stem cells (hMSCs) prevent senescence of stem cells in bisphosphonate-related osteonecrosis of the jaw model. In this study, we aimed to compare the effects of conditioned medium (hMSCs-CM) from early and late passage hMSCs on cellular senescence and to verify the benefits of CM from early passage hMSCs in mitigating the progression of osteoporosis through the prevention of cellular senescence. We investigated the distinct endocrine effects of early (P5) and late (P17) passage hMSCs in vitro, as well as the preventive benefits of early passage hMSCs-CM in osteoporosis model triggered by ovariectomy. Our results indicate that long-term cultured hMSCs contributed to the progression of inflammatory transcriptional programs in P5 hMSCs, ultimately impairing their functionality and enhancing senescence-related characteristics. Conversely, early passage hMSCs reversed these alterations. Moreover, early passage hMSCs-CM infused intravenously in a postmenopausal osteoporosis mouse model suppressed bone degeneration and prevented osteoporosis by reducing ovariectomy-induced senescence in bone marrow MSCs and reducing the expression of senescence-associated secretory phenotype-related cytokines. Our findings highlight the high translational value of early passage hMSCs-CM in antiaging intervention and osteoporosis prevention.
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| 6. |
- Maruyama, Toshi, et al.
(författare)
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Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain
- 2012
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Ingår i: Journal of Neurochemistry. - : John Wiley & Sons. - 0022-3042 .- 1471-4159. ; 121:6, s. 891-902
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Tidskriftsartikel (refereegranskat)abstract
- Signal regulatory protein α (SIRPα) is a neuronal membrane protein that undergoes tyrosine phosphorylation in the brain of mice in response to forced swim (FS) stress in cold water, and this response is implicated in regulation of depression-like behavior in the FS test. We now show that subjection of mice to the FS in warm (37°C) water does not induce the tyrosine phosphorylation of SIRPα in the brain. The rectal temperature (T(rec) ) of mice was reduced to 27° to 30°C by performance of the FS for 10 min in cold water, whereas it was not affected by the same treatment in warm water. The level of tyrosine phosphorylation of SIRPα in the brain was increased by administration of ethanol or picrotoxin, starvation, or cooling after anesthesia, all of which also induced hypothermia. Furthermore, the tyrosine phosphorylation of SIRPα in cultured hippocampal neurons was induced by lowering the temperature of the culture medium. CD47, a ligand of SIRPα, as well as Src family kinases or SH2 domain-containing protein phosphatase 2 (Shp2), might be important for the basal and the hypothermia-induced tyrosine phosphorylation of SIRPα. Hypothermia is therefore likely an important determinant of both the behavioral immobility and tyrosine phosphorylation of SIRPα observed in the FS test.
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| 7. |
- Ohnishi, Hiroshi, et al.
(författare)
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Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test
- 2010
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Ingår i: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 30:31, s. 10472-10483
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Tidskriftsartikel (refereegranskat)abstract
- Severe stress induces changes in neuronal function that are implicated in stress-related disorders such as depression. The molecular mechanisms underlying the response of the brain to stress remain primarily unknown, however. Signal regulatory protein alpha (SIRPalpha) is an Ig-superfamily protein that undergoes tyrosine phosphorylation and binds the protein tyrosine phosphatase Shp2. Here we show that mice expressing a form of SIRPalpha that lacks most of the cytoplasmic region manifest prolonged immobility (depression-like behavior) in the forced swim (FS) test. FS stress induced marked tyrosine phosphorylation of SIRPalpha in the brain of wild-type mice through activation of Src family kinases. The SIRPalpha ligand CD47 was important for such SIRPalpha phosphorylation, and CD47-deficient mice also manifested prolonged immobility in the FS test. Moreover, FS stress-induced tyrosine phosphorylation of both the NR2B subunit of the NMDA subtype of glutamate receptor and the K+-channel subunit Kvbeta2 was regulated by SIRPalpha. Thus, tyrosine phosphorylation of SIRPalpha is important for regulation of depression-like behavior in the response of the brain to stress.
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| 8. |
- Proletov, Ian, et al.
(författare)
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Primary and secondary glomerulonephritides 1.
- 2014
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 29 Suppl 3:May, s. 186-200
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Tidskriftsartikel (refereegranskat)
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| 9. |
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Re: Mindings : Co-Constituting Indigenous, Academic, Artistic Knowledges
- 2014
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- RE: Mindings brings together indigenous scholars, artists and activists, and indigenous allies to speak of whose positions, contexts and experiences it is that inform the construction of knowledges, histories and sciences. In short, whose experience counts? The purpose of RE:Mindings is to encourage its authors and readers to investigate what it means to resist exploitation of humans, non-humans and nature within the frames of modern nation states. Examples are provided from communities within or across the borders of existing nation states: Sámi and Saepmie/Sábme/Sápmi in Fenno-Scandinavia; Aboriginal-Martu in Australia; Ainu people in Japan, Dakota-Native Americans in USA and Mapuche in Chile. This publication originates from the supradisciplinary symposium RE: Mindings; Co-Constituting Indigenous/Academic/Artistic Knowledges and Understandings of Land-, Water-, Body-, and Lab-scapes, held at Uppsala University, 10-12 October 2012.The RE:Mindings publication has been funded through research projects financed by the Swedish Research Council (Vetenskapsrådet) and Formas - the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning.
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| 10. |
- Svalastog, Anna Lydia, 1966-, et al.
(författare)
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On Teachers’ Education in Sweden, School Curriculums, and the Sámi People
- 2014
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Ingår i: Re: Mindings. - Uppsala : The Hugo Valentin Centre, Uppsala University. - 9789186531102 ; , s. 153-171
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Bokkapitel (refereegranskat)abstract
- This article discusses the intersection of Teachers’ Education and the Swedish society with regards to Sámi religion, history and culture. It aims at a renewed understanding of present premises for construction of curriculums in courses on Sámi history, culture and religion. An important back drop is the Swedish State’s regulation of Teachers Education, their inclusion of indigenous peoples’ inte- rests, and the general demand for research based and reflexive academic teaching. I argue that Teachers’ Education and Swedish bookstores present research based knowledge on the Sámi People’s religion, history and culture in a weak and accidental manner. For a better understanding, I discuss Anthony Giddens’ description of society as regionalized into “back stage” and “front stage” regions structured by different rules – back stage rules being loosely structured and characterized by feelings, subjectivity and bodily activities, while front stage rules are strictly disciplined, and not characterized by personal feelings or bodily excursion. Universities and Colleges fit front stage characteristics, though Teachers’ Education, as well as Swedish bookstores, seems to be structured by back stage rules when it comes to the Sámi People. Giddens emphasizes how social encounters between people contribute to the construction of social institutions and their organization. As such, the loose link between research based teaching and Teachers Education regarding the Sámi people, generates societal consequences. If reflexivity is a major feature of present academic life, we should expect universities to change present premises for research based new curriculums regarding Sámi history, culture and religion. The argument forwarded in this article is thus that, first of all, this situation needs to be made visible. The blind spot has to be identified and targeted. Qualified and reflexive knowledge and competence in Sámi religion, history and culture need to be integrated within all disciplines of academic education. Secondly, I argue that there is an urgent need for the (re-)establishment of the discipline of Native Studies – Indigenous Studies headed and fronted by Sámi scholars – which would have the responsibility of developing and renewing research-based curriculums on Sámi culture, history and religion. To be able to reach the full extent and depth of Sámi religion, culture and history, this discipline needs to be directed by Sámi scholars.
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