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Sökning: WFRF:(Matejka G)

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1.
  • Nilsson, A B, et al. (författare)
  • IGF-I treatment attenuates renal abnormalities induced by neonatal ACE inhibition.
  • 2000
  • Ingår i: American journal of physiology. Regulatory, integrative and comparative physiology. - 0363-6119. ; 279:3
  • Tidskriftsartikel (refereegranskat)abstract
    • An intact renin-angiotensin system (RAS) during nephrogenesis is essential for normal renal development. We have shown previously that neonatal inhibition of the RAS, either with ANG II type 1-receptor blockade or angiotensin-converting enzyme (ACE) inhibition, induces irreversible renal abnormalities. The aim of the present study was to investigate whether an interrupted RAS can be compensated for by exogenous administration of another important renal growth-promoting factor, the insulin-like growth factor-I (IGF-I). Rats were treated daily with either the ACE inhibitor enalapril (10 mg/kg), recombinant human IGF-I (3 mg/kg), or the combination enalapril + IGF-I from perinatal day 3 to 13. Urinary concentrating ability, renal function, and renal morphology were assessed at adult age. The gene expression and localization of IGF-I, its receptor, and the growth hormone receptor (GHR) were investigated during ongoing ACE inhibition. The present study demonstrates normalized renal function and histology in enalapril + IGF-I-treated animals. Ongoing ACE inhibition suppressed the medullary IGF-I mRNA expression and altered the local distribution of both IGF-I and GHR. Thus the present study provides evidence for an interaction between the RAS and GH/IGF-I axis in renal development.
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  • Ekman, Inger, et al. (författare)
  • Outpatient care programmes for the elderly
  • 1999
  • Ingår i: European Heart Journal. - London, United Kingdom : W. B. Saunders Co. Ltd.. - 0195-668X .- 1522-9645. ; 20:5, s. 393-4
  • Tidskriftsartikel (refereegranskat)
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  • Matějka, V., et al. (författare)
  • On the running-in of brake pads and discs for dyno bench tests
  • 2017
  • Ingår i: Tribology International. - : Elsevier Ltd. - 0301-679X .- 1879-2464. ; 115, s. 424-431
  • Tidskriftsartikel (refereegranskat)abstract
    • Running-in process of low metallic brake pads and cast iron discs are investigated using full scale inertia brake dynamometer designed for particle emission studies. The airborne particles are measured using ELPI+ and collected on filters. The pads and disc contact surfaces are studied using microscopy techniques. It is observed that the particle emissions from the new pads and discs are significantly higher compared with the used ones and indicates importance of proper running-in of the pads and disc for wear particle emission tests. The results also indicate that pads and disc pairs which are able to stabilize friction behavior faster will produce less particle emissions which could influence the strategies of brake material formulations or steps during their production.
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  • Resultat 1-7 av 7

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