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- Sonesson, Mikael, et al.
(författare)
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Minor salivary gland secretion in children and adults
- 2003
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Ingår i: Archives of Oral Biology. - : Elsevier. - 0003-9969 .- 1879-1506. ; 48:7, s. 535-539
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Tidskriftsartikel (refereegranskat)abstract
- The minor salivary glands are of great importance in the physiology and pathology of the oral cavity. So far, studies of the minor glands have concentrated on adults. In the present study, minor salivary gland secretion was studied in the buccal and labial mucosa of 3-year-old children, adolescents and young adults. In addition, the number of glands per surface area was assessed in the labial mucosa. A total of 90 individuals were included, 30 in each age-group. Saliva was collected on filter paper discs and the salivary secretion rate was measured using a Periotron 8000. The number of secreting labial glands was assessed on PAS-stained filter paper discs under a microscope. Salivary secretion in the buccal mucosa was found to be age-related, with a statistically significant lower rate of secretion (P=0.003) in the 3-year-olds (mean 7.7 microl x cm(-2) x min(-1)) compared with the young adults (11.9 microl x cm(-2) x min(-1)). No significant differences between the sexes were noted. For the labial glands, no age- or sex-related differences were found. In all age-groups, salivary secretion was significantly higher in the buccal than in the labial mucosal area. A statistically significant difference in number of secreting glands was found between all age-groups, with a decreasing number of glands per surface unit with age. The number of glands was significantly lower in males compared with females in the group of adults. The lower rate of buccal salivary secretion in the young children may imply that the oral mucosa is more vulnerable to external injury and that caries protection on the buccal molar surfaces is lower. Previous studies indicate that adults with a reduced rate of minor salivary gland secretion are more susceptible to caries.
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| 2. |
- Bergman, Ebba, 1977-, et al.
(författare)
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Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers
- 2010
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Ingår i: Journal of clinical pharmacology. - : Wiley. - 0091-2700 .- 1552-4604. ; 50:9, s. 1039-1049
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Tidskriftsartikel (refereegranskat)abstract
- The effect of a single intrajejunal dose of gemfibrozil (600 mg) on the plasma pharmacokinetics and biliary excretion of a single intrajejunal dose of rosuvastatin (20 mg) was investigated by using a multichannel catheter positioned in the distal duodenum/proximal jejunum in eight healthy volunteers. Bile and plasma samples were collected every 20 min for 200 min, with additional plasma samples being withdrawn for up to 48 hrs. Gemfibrozil did not affect the bioavailability of rosuvastatin, although it increased the apparent absorption phase during the initial 200 minutes (AUC0-200) by 1.56-fold (95%CI: 1.14-2.15). The interaction was less pronounced in this single dose study than in a previous report when gemfibrozil was administered repeatedly, nevertheless, the interaction coincided with the highest exposure to gemfibrozil. The plausible reason why the interaction in this investigation was only minor is the low exposure to gemfibrozil (and its metabolites), suggesting that the total plasma concentration of gemfibrozil needs to be above 20 µM in order to affect the disposition of rosuvastatin. This study demonstrates the value of monitoring the plasma pharmacokinetics of the inhibitor, and not only the drug under investigation, to improve the mechanistic interpretation.
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| 3. |
- Bergman, Frida, Medicine doktor, 1984-, et al.
(författare)
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Walking Time Is associated With Hippocampal Volume in Overweight and Obese Office Workers
- 2020
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Ingår i: Frontiers in Human Neuroscience. - : Frontiers Media S.A.. - 1662-5161. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To investigate the long-term effects on cognition and brain function after installing treadmill workstations in offices for 13 months.Methods: Eighty healthy overweight or obese office workers aged 40–67 years were individually randomized to an intervention group, receiving a treadmill workstation and encouraging emails, or to a control group, continuing to work as usual. Effects on cognitive function, hippocampal volume, prefrontal cortex (PFC) thickness, and circulating brain-derived neurotrophic factor (BDNF) were analyzed. Further, mediation analyses between changes in walking time and light-intensity physical activity (LPA) on changes in BDNF and hippocampal volume between baseline and 13 months, and multivariate analyses of the baseline data with percentage sitting time as the response variable, were performed.Results: No group by time interactions were observed for any of the outcomes. In the mediation analyses, positive associations between changes in walking time and LPA on changes in hippocampal volume were observed, although not mediated by changes in BDNF levels. In the multivariate analyses, a negative association between percentage sitting time and hippocampal volume was observed, however only among those older than 51 years of age.Conclusion: Although no group by time interactions were observed, our analyses suggest that increased walking and LPA may have positive effects on hippocampal volume and that sedentary behavior is associated with brain structures of importance for memory functions.Trial Registration: www.ClinicalTrials.gov as NCT01997970.
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| 7. |
- Brogårdh-Roth, Susanne, et al.
(författare)
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Dental anxiety patterns in adolescents born preterm compared with matched controls
- 2009
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Ingår i: International Journal of Paediatric Dentistry. - 0960-7439 .- 1365-263X. ; 19:Supplement 1, s. 66-170
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Introduction A high frequency of cognitive and behavioural disturbances has been reported in preterm children. It is not known if this affects the children’s apperceptions or behaviours during dental treatment. The aim was therefore to investigate dental behavioural management problems (BMP) and dental anxiety (DA) in preterm children from age 3-14, and to compare with matched controls. Materials and Methods 187 preterm children (23-32 weeks of gestation), born 1994-96 were followed regarding BMP and DA. Comparisons were made with matched full-term controls. Data on BMP were collected from dental records for the ages 3 and 6 yrs. During the school years, parents were interviewed twice regarding BMP in their children. Two periods of time were covered; preschool period, and early school years. Finally, at 12-14 yrs the children filled out the CFSS-DS scale, measuring DA. Results During pre-school years pre-term children showed significantly more BMP at various kinds of dental treatments (32% vs. 15%; p<0.001). This was confirmed in the first interviews of the parents (20%vs. 10%; p=0.028). At the second interviews, covering early school years, no differences were found between the groups. This was also verified by the children’s scorings on CFSS-DS at age 12-14 where no differences in mean scores were revealed. Conclusion Children born preterm seem to have a high prevalence of BMP during preschool years. But this difference decreases with increasing age, possibly reflecting a catch-up. At school years and early adolescence no differences were seen between the groups regarding BMP or DA.
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| 8. |
- Brogårdh-Roth, Susanne, et al.
(författare)
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Dental behavioural management problems and dental caries prevalence in 3-to 6-year-old Swedish children born preterm
- 2008
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Ingår i: International Journal of Paediatric Dentistry. - 0960-7439 .- 1365-263X. ; 18:5, s. 341-347
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Tidskriftsartikel (refereegranskat)abstract
- Background. Today, most children born preterm survive without major impairments. But high frequencies of cognitive and behavioural difficulties arise. Studies on dental behavioural management problems (DBMP) in these children are lacking. In addition, studies on caries prevalence are few and inconclusive. Aim. This study aims to compare the frequency of behavioural problems and poor compliance with dental treatment in preschool children born preterm with those born full-term. The prevalence of caries was also studied. Methods. The study group included 187 children born between 23 and 32 weeks of gestation. The control group constituted full-term children matched by age, sex, immigrant background, and dental operator. DBMP, number of dental visits, missed appointments, and caries between ages 3 and 6 were noted. Results. At age 3, but not at age 6, the prevalence of DBMP at clinical examinations was significantly higher in preterm children compared with the control group. Of the children who received dental treatments during preschool years, preterm children displayed significantly more DBMP. No significant difference in dental visits or in caries prevalence was found. Preterm children, however, missed significantly more dental appointments. Conclusion. Children born preterm display a higher prevalence of DBMP at dental examinations and treatments during preschool years.
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| 9. |
- Brogårdh-Roth, Susanne, et al.
(författare)
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Dental fear and anxiety and oral health behaviour in 12-to-14-year-olds born preterm
- 2010
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Ingår i: International Journal of Paediatric Dentistry. - 0960-7439 .- 1365-263X. ; 20:6, s. 391-399
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: An enhanced frequency of cognitive and behavioural disturbances has been reported in preterm children. It is not known if this affects their perceptions of or behaviour in the dental care situation. HYPOTHESIS: The hypotheses were that preterm (PT) children aged 12-14 years more often exhibit dental fear and anxiety (DFA) than full-term controls (C), while no differences were expected regarding oral health behaviour. METHODS: One hundred and nine PT and 108 C children took part in the present questionnaire study. DFA was assessed using the Children's Fear Survey Schedule - Dental Subscale (CFSS-DS). In addition the questionnaire covered items including satisfaction with received dental care, oral health behaviour and medical health. RESULTS: The children's CFSS-DS scores revealed no differences between the PT and C groups. Regarding oral health behaviour there were no differences, except that PT children more often used dental floss and extra fluoride supplements. PT children reported more medical health problems than C children. CONCLUSIONS: Preterm (PT) children 12- to 14-years-old, as well as C of same age group, seem to be satisfied with their dental care and display low prevalence of DFA. Still, a higher frequency of medical health problems in the PT children suggests that these children should be regarded as potential risk patients for oral health problems.
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