| 1. |
- Joshi, Peter K, et al.
(författare)
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Directional dominance on stature and cognition in diverse human populations
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 523:7561, s. 459-462
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Tidskriftsartikel (refereegranskat)abstract
- Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.
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| 2. |
- Hammar, Linus, 1979, et al.
(författare)
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Cumulative impact assessment for ecosystem-based marine spatial planning
- 2020
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 734
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Tidskriftsartikel (refereegranskat)abstract
- Claims for ocean space are growing while marine ecosystems suffer from centuries of insufficient care. Human pressures from runoff, atmospheric emissions, marine pollution, fishing, shipping, military operations and other activities wear on habitats and populations. Ecosystem-based marine spatial planning (MSP) has emerged worldwide as a strategic instrument for handling conflicting spatial claims among competing sectors and the environment. The twofold objective of both boosting the blue economy and protecting the environment is challenging in practice and marine planners need decision support. Cumulative Impact Assessment (CIA) was originally developed to provide an overview of the human imprint on the world's ocean ecosystems. We have now added a scenario component to the CIA model and used it within Swedish ecosystem-based MSP. This has allowed us to project environmental impacts for different planning alternatives throughout the planning process, strengthening the integration of environmental considerations into strategic decision-making. Every MSP decision may entail a local shift of environmental impact, causing positive or negative consequences for ecosystem components. The results from Swedish MSP in the North Sea and Baltic Sea illustrate that MSP certainly has the potential to lower net cumulative environmental impact, both locally and across sea basins, as long as environmental values are rated high and prevailing pressures derive from activities that are part of MSP. By synthesizing innumerous data into comprehensible decision support that informs marine planners of the likely environmental consequences of different options, CIA enables ecosystem-based MSP in practice.
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| 3. |
- Jansen, Willemijn J, et al.
(författare)
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Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
- 2015
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Ingår i: JAMA. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 313:19, s. 1924-38
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.
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| 4. |
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| 5. |
- Abugabbara, Marwan, et al.
(författare)
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How to develop fifth-generation district heating and cooling in Sweden? : Application review and best practices proposed by middle agents
- 2023
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Ingår i: Energy Reports. - : Elsevier Ltd. - 2352-4847. ; 9, s. 4971-4983
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Tidskriftsartikel (refereegranskat)abstract
- Sweden has an ambitious plan to fully decarbonise district heating by 2030 and to contribute with negative emissions of greenhouse gases in 2050. The vagaries of the energy market associated with climate, political, and social changes entail cross-sectoral integration that can fulfill these national targets. Fifth-generation district heating and cooling (5GDHC) is a relatively new concept of district energy systems that features a simultaneous supply of heating and cooling using power-to-heat technologies. This paper presents best practices for developing 5GDHC systems in Sweden to reach a consensus view on these systems among all stakeholders. A mixed-method combining best practice and roadmapping workshops has been used to disseminate mixed knowledge and experience from middle agents representing industry professionals and practitioners. Four successful implementations of 5GDHC systems are demonstrated and the important learned lessons are shared. The best practices are outlined for system planning, system modeling and simulation, prevailing business models for energy communities, and system monitoring. A roadmap from the middle agents’ point of view is composed and can be utilised to establish industry standards and common regulatory frameworks. © 2023 The Author(s)
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| 6. |
- Almqvist, Bjarne, et al.
(författare)
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Magnetic characterisation of magnetite and hematite from the Blötberget apatite-iron-oxide deposits (Bergslagen), south-central Sweden
- 2019
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Ingår i: Canadian journal of earth sciences (Print). - : Canadian Science Publishing. - 0008-4077 .- 1480-3313. ; 56:9, s. 948-957
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Tidskriftsartikel (refereegranskat)abstract
- Rock magnetic measurements were carried out on drill core material and hand specimens from the Blötberget apatite-iron oxide deposit in the Bergslagen ore province, south-central Sweden, to characterise their magnetic properties. Measurements included several kinds of magnetic susceptibility and hysteresis parameters. Petrographic and scanning electron microscopy (SEM) were used to independently identify and quantify the amount and type of magnetite and hematite. Two hematite-rich samples were studied with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to quantify the trace element chemistry in hematite and investigate the potential influence of trace elements on magnetic properties. Three aspects of this study are noteworthy. 1) Hematite-rich samples display strong anisotropy of magnetic susceptibility, which is likely to affect the appearance and modelling of magnetic anomalies. 2) The magnitude-drop in susceptibility across Curie and Néel temperature transitions show significant correlation with the respective weight percent (wt%) of magnetite and hematite. Temperature dependent magnetic susceptibility measurements can therefore be used to infer the amounts of both magnetite and hematite. 3) observations of a strongly depressed Morin transition at ca -60 to -70 C (200 to 210 K) are made during low-temperature susceptibility measurements. This anomalous Morin transition is most likely related to trace amounts of V and Ti that substitute for Fe in the hematite. When taken together, these magnetic observations improve the understanding of the magnetic anomaly signature of the Blötberget apatite-iron oxide deposits and may potentially be utilised in a broader context when assessing similar (Paleoproterozoic) apatite-iron oxide systems.
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| 7. |
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| 8. |
- Axelsson, Charlotte, 1970, et al.
(författare)
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SpringFlow: A Digital Spring-sign
- 2002
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Ingår i: Proceedings of the second Nordic conference on Human-computer interaction , Aarhus, Denmark, Jun. 2005.. - 1581136161 ; , s. 297-298
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Konferensbidrag (refereegranskat)abstract
- We present SpringFlow, a digital Spring-sign, which, from February to May, changes its characteristics to indicate how far gone spring is. With the aid of our Spring-sign, you navigate through time just like you would with a calendar. Its construction resembles a hollow ball, while the appearance of it depends on the users interactions. By tilting it, changes in sound, light, heat and cold will be produced. Based upon prior work in ubiquitous computing, SpringFlow incorporates old techniques to create something new. This paper describes the components, interaction, implementation, conceptual approach, but most of all the aesthetics
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| 9. |
- Azar, Christian, 1969, et al.
(författare)
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Meeting global temperature targets-the role of bioenergy with carbon capture and storage
- 2013
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9318 .- 1748-9326. ; 8:3
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Tidskriftsartikel (refereegranskat)abstract
- In order to meet stringent temperature targets, active removal of CO2 from the atmosphere may be required in the long run. Such negative emissions can be materialized when well-performing bioenergy systems are combined with carbon capture and storage (BECCS). Here, we develop an integrated global energy system and climate model to evaluate the role of BECCS in reaching ambitious temperature targets. We present emission, concentration and temperature pathways towards 1.5 and 2 degrees C targets. Our model results demonstrate that BECCS makes it feasible to reach temperature targets that are otherwise out of reach, provided that a temporary overshoot of the target is accepted. Additionally, stringent temperature targets can be met at considerably lower cost if BECCS is available. However, the economic benefit of BECCS nearly vanishes if an overshoot of the temperature target is not allowed. Finally, the least-cost emission pathway over the next 50 years towards a 1.5 degrees C overshoot target with BECCS is almost identical to a pathway leading to a 2 degrees C ceiling target.
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| 10. |
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