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- Jansen, Nathalie W. D., et al.
(författare)
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The Combination of the Biomarkers Urinary C-Terminal Telopeptide of Type II Collagen, Serum Cartilage Oligomeric Matrix Protein, and Serum Chondroitin Sulfate 846 Reflects Cartilage Damage in Hemophilic Arthropathy
- 2009
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 1529-0131 .- 0004-3591. ; 60:1, s. 290-298
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Tidskriftsartikel (refereegranskat)abstract
- Objective. Hemophilic arthropathy, with characteristics of inflammatory (rheumatoid arthritis) and degenerative (osteoarthritis) joint damage, occurs at an early age, is associated with minor comorbidity, and is restricted to 3 pairs of large joints. The aim of this study was to determine whether commonly used serum and/or urinary biomarkers of cartilage and bone turnover for which assay kits are commercially available are associated with the severity of joint damage in patients with various degrees of hemophilic arthropathy and, thus, whether this disease could be useful in the identification and evaluation of such biomarkers. Methods. Blood and urine samples were collected from 36 patients with various degrees of hemophilic arthropathy. Commercially available assays for the most frequently investigated serum and urine biomarkers were performed: urinary C-terminal telopeptide of type I collagen (CTX-I), urinary CTX-II, serum CTX-I, serum CTX-II, serum cartilage oligomeric matrix protein (COMP), serum cartilage cleavage products C1,2C and C2C, and serum chondroitin sulfate 846 (CS-846). Radiographs of the ankles, knees, and elbows in all patients were evaluated for the degree of joint damage according to the Pettersson score, which is based on cartilage and periarticular bone changes and is specific for hemophilic arthropathy. Results. Urinary CTX-II, serum C1,2C, and serum CS-846 levels correlated with the overall Pettersson score and with the joint space narrowing component. Regression analysis showed that combined indexes of different markers increased the degree of correlation for the combination of urinary CTX-II, serum COMP, and serum CS-846. Bone-specific markers (urinary/serum CTX-I and serum C1,2C) did not correlate with specific bone-related items of the Pettersson score (osteoporosis and erosions). Conclusion. These results support the idea that a combination of biomarkers relates significantly better to the severity of joint damage than do individual biomarkers. The combination of urinary CTX-II, serum COMP, and serum CS-846 correlated best with the degree of arthropathy. Because of its specific characteristics and restricted involvement, hemophilic arthropathy may prove useful in the screening of newly developed biomarkers of joint damage.
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- Barthel, Roland, 1967, et al.
(författare)
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An integrated modelling framework for simulating regional-scale actor responses to global change in the water domain
- 2008
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Ingår i: Environmental Modelling & Software. - : Elsevier BV. - 1364-8152. ; 23:9, s. 1095-1121
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Tidskriftsartikel (refereegranskat)abstract
- Within coupled hydrological simulation systems, taking socio-economic processes into account is still a challenging task. In particular, systems that aim at evaluating impacts of climatic change on large spatial and temporal scales cannot be based on the assumption that infrastructure, economy, demography and other human factors remain constant while physical boundary conditions change. Therefore, any meaningful simulation of possible future scenarios needs to enable socio-economic systems to react and to adapt to climatic changes. To achieve this it is necessary to simulate decision-making processes of the relevant actors in a way which is adequate for the scale, the catchment specific management problems to be investigated and finally the data availability. This contribution presents the DEEPACTOR approach for representing such human decision processes, which makes use of a multi-actor simulation framework and has similarities to agent-based approaches. This DEEPACTOR approach is embedded in DANUBIA, a coupled simulation system comprising 16 individual models to simulate Global Change impacts on the entire water cycle of the Upper Danube Catchment (Germany, 77,000 km(2)). The applicability of DANUBIA and in particular the DEEPACTOR approach for treating the socio-economic part of the water cycle in a process-based way is demonstrated by means of concrete simulation models of the water supply sector and of the domestic water users. Results from scenario simulations are used to demonstrate the capabilities and limitations of the approach. (c) 2008 Elsevier Ltd. All rights reserved.
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- Barthel, Roland, 1967, et al.
(författare)
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Global change impacts on groundwater in Southern Germany-Part 1: Natural aspects
- 2011
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Ingår i: Grundwasser. - : Springer Science and Business Media LLC. - 1430-483X .- 1432-1165. ; 16:4, s. 247-257
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Tidskriftsartikel (refereegranskat)abstract
- In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube (www. glowa-danube. de) has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article represents part 1 of an article series and describes groundwater and natural aspects of the investigations, while part 2 describes socio-economic aspects (Barthel et al. in Grundwaser 16(4), doi:10. 1007/s00767-011-0180-y, 2011). Here we describe concepts of GLOWA-Danube and DANUBIA as well as groundwater-related model components. This leads to selected simulation results for water balance, groundwater quantity and quality. The chosen scenarios show decreasing precipitation, increasing temperatures, and changes in the annual distribution that lead to significant decreases in groundwater recharge. Regional predictions of groundwater quality were difficult to achieve because of complex soil and groundwater processes. However, climatic change will probably have little impact. © 2011 Springer-Verlag.
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- Barthel, Roland, 1967, et al.
(författare)
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Global change impacts on groundwater in Southern Germany-Part 2: Socioeconomic aspects
- 2011
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Ingår i: Grundwasser. - : Springer Science and Business Media LLC. - 1430-483X .- 1432-1165. ; 16:4, s. 259-268
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Tidskriftsartikel (refereegranskat)abstract
- In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube http://www. glowa-danube. de has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article describes part 2 of an article series with investigations of socio-economic aspects, while part 1 (Barthel et al. in Grundwasser 16(4), doi:10. 1007/s007-011-01794, 2011) deals with natural-spatial aspects. The principles of socio-economic actor-modeling and interactions between socio-economic and natural science model components are described here. We present selected simulations that show impacts on groundwater from changes in agriculture, tourism, economy, domestic water users and water supply. Despite decreases in water consumption, the scenario simulations show significant decreases in groundwater quantity. On the other hand, groundwater quality will likely be influenced more severely by land use changes compared to direct climatic causes. However, overall changes will not be dramatic. © 2011 Springer-Verlag.
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