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- Forsberg, A., et al.
(författare)
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The Immune Response of the Human Brain to Abdominal Surgery
- 2017
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Ingår i: Annals of Neurology. - : Wiley. - 0364-5134 .- 1531-8249. ; 81:4, s. 572-582
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. Although preclinical studies have in part described this systemic-to-brain signaling pathway, we lack information on how these changes appear in humans. This study examines the short-and long-term impact of abdominal surgery on the human brain immune system by positron emission tomography (PET) in relation to blood immune reactivity, plasma inflammatory biomarkers, and cognitive function. Methods: Eight males undergoing prostatectomy under general anesthesia were included. Prior to surgery (baseline), at postoperative days 3 to 4, and after 3 months, patients were examined using [C-11]PBR28 brain PET imaging to assess brain immune cell activation. Concurrently, systemic inflammatory biomarkers, ex vivo blood tests on immunoreactivity to lipopolysaccharide (LPS) stimulation, and cognitive function were assessed. Results: Patients showed a global downregulation of gray matter [C-11]PBR28 binding of 26 +/- 26% (mean +/- standard deviation) at 3 to 4 days postoperatively compared to baseline (p=0.023), recovering or even increasing after 3 months. LPS-induced release of the proinflammatory marker tumor necrosis factor-a in blood displayed a reduction (41 +/- 39%) on the 3rd to 4th postoperative day, corresponding to changes in [C-11]PBR28 distribution volume. Change in Stroop Color-Word Test performance between postoperative days 3 to 4 and 3 months correlated to change in [C-11]PBR28 binding (p=0.027). Interpretation: This study translates preclinical data on changes in the brain immune system after surgery to humans, and suggests an interplay between the human brain and the inflammatory response of the peripheral innate immune system. These findings may be related to postsurgical impairments of cognitive function.
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- Holmquist, Lars Erik, et al.
(författare)
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Building Intelligent Environments with Smart-Its
- 2004
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Ingår i: IEEE Computer Graphics and Applications. - 0272-1716 .- 1558-1756. ; 24:1, s. 56-64
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Tidskriftsartikel (refereegranskat)abstract
- The development of Smart-Its for building smart environments is discussed. Smart-Its are small, self-contained, stick-on computers that attach to everyday objects. These augmented objects become soft media, enabling dynamic digital relationships with users and each other. A Smart-Its consists of a core board with a wireless transceiver to let the device communicate with other Smart-Its, plus a sensor board that gives the Smart-Its data about its sorroundings. The major advantage of the system is that it allows designers and researchers to construct responsive or intelligent environments.
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- Jacobs, M., et al.
(författare)
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Design-by-doing: workshops for designing interaction
- 2004. - 4
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Ingår i: Proceedings of the eighth conference on Participatory design.
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Konferensbidrag (refereegranskat)abstract
- We have been developing methods that will support us, as designers, in approaching the complex and indeterminate factors that come into play in the design of new computational things for everyday life. In our investigation, we have involved students from diverse design educations in workshops inspired by participatory methods. Through hands-on and situated activity formats, these workshops have provided examples and perspectives on working with computation as a design material in combination with experiential notions of materials, use and context.
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| 10. |
- Mazé, Ramia, et al.
(författare)
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Mixers: A participatory approach to design prototyping
- 2002. - 10
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Ingår i: Proceedings of DIS. ; , s. 341-344
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Konferensbidrag (refereegranskat)abstract
- In this design exhibit, we describe methods we have used to design a noticeboard interface for an older community in London. Three low-fidelity methods of prototyping interaction provided shared and accessible means for us and our end users to communicate design ideas, explore qualities of the user experience, and evaluate them within situations of use. This approach facilitated the development of an appropriate, innovative and feasible solution for a unique context.
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