| 1. |
- Kaluzhskikh, M. S., et al.
(författare)
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High-temperature crystal structure and transport properties of the layered cuprates Ln(2)CuO(4), Ln=Pr, Nd and Sm
- 2011
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Ingår i: Journal of Solid State Chemistry. - : Elsevier BV. - 0022-4596 .- 1095-726X. ; 184:3, s. 698-704
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Tidskriftsartikel (refereegranskat)abstract
- High-temperature crystal structure of the layered cuprates Ln(2)CuO(4), Ln = Pr, Nd and Sm with tetragonal T'-structure was refined using X-ray powder diffraction data. Substantial anisotropy of the thermal expansion behavior was observed in their crystal structures with thermal expansion coefficients (TEC) along a- and c-axis changing from TEC(a)/TEC(c)approximate to 1.37 (Pr) to 0.89 (Nd) and 0.72 (Sm). Temperature dependence of the interatomic distances in Ln(2)CuO(4) shows significantly lower expansion rate of the chemical bond between Pr and oxygen atoms (O1) belonging to CuO(2)-planes (TEC(Pr-O1)= 11.7 ppm K(-1)) in comparison with other cuprates: TEC (Nd-O1)=15.2 ppm K(-1) and TEC (Sm-O1)= 15.1 ppm K(-1). High-temperature electrical conductivity of Pr(2)CuO(4) is the highest one in the whole studied temperature range (298-1173 K): 0.1-108 S/cm for Pr(2)CuO(4), 0.07-23 S/cm for Nd(2)CuO(4) and 2 X 10(-4)-9 S/cm for Sm(2)CuO(4). The trace diffusion coefficient (D(T)) of oxygen for Pr(2)CuO(4) determined by isotopic exchange depth profile (IEDP) technique using secondary ion mass spectrometry (SIMS) varies in the range 7.2 X 10(-13) Cm(2)/S (973 K) and 3.8 X 10(-10) Cm(2)/S (1173 K) which are in between those observed for the manganese and cobalt-based perovskites.
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| 2. |
- Kotelnikova, E, et al.
(författare)
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Signaling networks in MS: a systems-based approach to developing new pharmacological therapies
- 2015
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Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 21:2, s. 138-146
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Tidskriftsartikel (refereegranskat)abstract
- The pathogenesis of multiple sclerosis (MS) involves alterations to multiple pathways and processes, which represent a significant challenge for developing more-effective therapies. Systems biology approaches that study pathway dysregulation should offer benefits by integrating molecular networks and dynamic models with current biological knowledge for understanding disease heterogeneity and response to therapy. In MS, abnormalities have been identified in several cytokine-signaling pathways, as well as those of other immune receptors. Among the downstream molecules implicated are Jak/Stat, NF-Kb, ERK1/3, p38 or Jun/Fos. Together, these data suggest that MS is likely to be associated with abnormalities in apoptosis/cell death, microglia activation, blood-brain barrier functioning, immune responses, cytokine production, and/or oxidative stress, although which pathways contribute to the cascade of damage and can be modulated remains an open question. While current MS drugs target some of these pathways, others remain untouched. Here, we propose a pragmatic systems analysis approach that involves the large-scale extraction of processes and pathways relevant to MS. These data serve as a scaffold on which computational modeling can be performed to identify disease subgroups based on the contribution of different processes. Such an analysis, targeting these relevant MS-signaling pathways, offers the opportunity to accelerate the development of novel individual or combination therapies.
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| 3. |
- Mazo, G. N., et al.
(författare)
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Influence of structural arrangement of R2O2 slabs of layered cuprates on high-temperature properties important for application in IT-SOFC
- 2014
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Ingår i: Solid State Ionics. - : Elsevier BV. - 0167-2738 .- 1872-7689. ; 257, s. 67-74
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Tidskriftsartikel (refereegranskat)abstract
- Layered cuprates Pr2 - xSrxCuO4-delta with T* (x = 0.3, 0.4) and T (x = 1.0, 13) structures were prepared in air at 1273-1373 K. Oxygen content (4 - delta) of the as-prepared phases decreases from 3.96 (x = 03) and 3.98 (x = 0.4) to 3.69 (x = 1.0) and 3.49 (x = 1.3), respectively, as determined by chemical titration. Dilatometry measurements revealed non-linear expansion with low- and high-temperature regions occurring due to thermogravimetrically detected oxygen loss. Different expansion behaviors in low- and high-temperature regions of T- and T*-phases are attributed to various distributions of oxygen vacancies in their crystal structures. Both x = 0.4 and 1.0 ceramic samples exhibit lower conductivity values at high temperatures in comparison with undoped Pr2CuO4. The temperature dependences of the electrical conductivity at variable oxygen partial pressure (Po-2 = 10(-4)-0.21 atm) reveal different mechanisms of the holes generation in x = 0.4 and 1.0 compounds. The tracer diffusion coefficient of oxygen (D-T) in Pr1.6Sr0.4CuO3.98 determined by isotopic exchange depth profile (IEDP) technique using secondary ion mass spectrometry (SIMS) is in the range 6.7 x 10(-10)-5.7 x 10(-8) cm(2)/s at 973-1223 K. Obtained values are in between those for La2CuO4 and Pr2CuO4 with pure rock-salt and fluorite slabs in the crystal structure, respectively. This shows the importance of rock-salt slabs for high oxygen conductivity in R2MO4 oxides.
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| 4. |
- Sanabria-Mazo, Juan P., et al.
(författare)
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Efficacy, cost-utility and physiological effects of Acceptance and Commitment Therapy (ACT) and Behavioural Activation Treatment for Depression (BATD) in patients with chronic low back pain and depression : study protocol of a randomised, controlled trial including mobile-technology-based ecological momentary assessment (IMPACT study)
- 2020
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 10:7
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Tidskriftsartikel (refereegranskat)abstract
- Introduction The IMPACT study focuses on chronic low back pain (CLBP) and depression symptoms, a prevalent and complex problem that represents a challenge for health professionals. Acceptance and Commitment Therapy (ACT) and Brief Behavioural Activation Treatment for Depression (BATD) are effective treatments for patients with persistent pain and depression, respectively. The objectives of this 12 month, multicentre, randomised, controlled trial (RCT) are (i) to examine the efficacy and cost-utility of adding a group-based form of ACT or BATD to treatment-as-usual (TAU) for patients with CLBP and moderate to severe levels of depressive symptoms; (ii) identify pre-post differences in levels of some physiological variables and (iii) analyse the role of polymorphisms in theFKBP5gene, psychological process measures and physiological variables as mediators or moderators of long-term clinical changes. Methods and analysis Participants will be 225 patients with CLBP and moderate to severe depression symptoms recruited at Parc Sanitari Sant Joan de Deu (St. Boi de Llobregat, Spain) and Hospital del Mar (Barcelona, Spain), randomly allocated to one of the three study arms: TAU vs TAU+ACT versus TAU+BATD. A comprehensive assessment to collect clinical variables and costs will be conducted pretreatment, post-treatment and at 12 months follow-up, being pain interference the primary outcome measure. The following physiological variables will be considered at pretreatment and post-treatment assessments in 50% of the sample: immune-inflammatory markers, hair cortisol and cortisone, serum cortisol, corticosteroid-binding globulin and vitamin D. Polymorphisms in theFKBP5gene (rs3800373, rs9296158, rs1360780, rs9470080 and rs4713916) will be analysed at baseline assessment. Moreover, we will include mobile-technology-based ecological momentary assessment, through the Pain Monitor app, to track ongoing clinical status during ACT and BATD treatments. Linear mixed-effects models using restricted maximum likelihood, and a full economic evaluation applying bootstrapping techniques, acceptability curves and sensitivity analyses will be computed. Ethics and dissemination This study has been approved by the Ethics Committee of the Fundacio Sant Joan de Deu and Hospital del Mar. The results will be actively disseminated through peer-reviewed journals, conference presentations, social media and various community engagement activities.
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