| 1. |
- Nijkamp, P., et al.
(författare)
-
Towards a regional science academy : A manifesto
- 2016
-
Ingår i: Region. - : European Regional Science Association. - 2409-5370. ; 3:1, s. R1-R16
-
Tidskriftsartikel (refereegranskat)abstract
- This Manifesto provides a joint proposal to create a Regional Science Academy as a think-tank support platform for a strategic development of the spatial sciences. The Regional Science Academy is a strategic spatial knowledge catalyst: it acts as a global intellectual powerhouse for new knowledge network initiatives and scholarly views on regions and cities as vital centrepieces of interconnected spatial systems. This contribution highlights its role and presents various activity plans.
|
|
| 2. |
- Uijterwijk, Bas A., et al.
(författare)
-
The road to tailored adjuvant chemotherapy for all four non-pancreatic periampullary cancers: An international multimethod cohort study
- 2024
-
Ingår i: British Journal of Cancer. - : SPRINGERNATURE. - 0007-0920 .- 1532-1827.
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Despite differences in tumour behaviour and characteristics between duodenal adenocarcinoma (DAC), the intestinal (AmpIT) and pancreatobiliary (AmpPB) subtype of ampullary adenocarcinoma and distal cholangiocarcinoma (dCCA), the effect of adjuvant chemotherapy (ACT) on these cancers, as well as the optimal ACT regimen, has not been comprehensively assessed. This study aims to assess the influence of tailored ACT on DAC, dCCA, AmpIT, and AmpPB. Patients and methods: Patients after pancreatoduodenectomy for non-pancreatic periampullary adenocarcinoma were identified and collected from 36 tertiary centres between 2010 - 2021. Per non-pancreatic periampullary tumour type, the effect of adjuvant chemotherapy and the main relevant regimens of adjuvant chemotherapy were compared. The primary outcome was overall survival (OS). Results: The study included a total of 2866 patients with DAC (n = 330), AmpIT (n = 765), AmpPB (n = 819), and dCCA (n = 952). Among them, 1329 received ACT, and 1537 did not. ACT was associated with significant improvement in OS for AmpPB (P = 0.004) and dCCA (P < 0.001). Moreover, for patients with dCCA, capecitabine mono ACT provided the greatest OS benefit compared to gemcitabine (P = 0.004) and gemcitabine - cisplatin (P = 0.001). For patients with AmpPB, no superior ACT regime was found (P > 0.226). ACT was not associated with improved OS for DAC and AmpIT (P = 0.113 and P = 0.445, respectively). Discussion: Patients with resected AmpPB and dCCA appear to benefit from ACT. While the optimal ACT for AmpPB remains undetermined, it appears that dCCA shows the most favourable response to capecitabine monotherapy. Tailored adjuvant treatments are essential for enhancing prognosis across all four non-pancreatic periampullary adenocarcinomas.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Menkveld, Albert J., et al.
(författare)
-
Nonstandard Errors
- 2024
-
Ingår i: JOURNAL OF FINANCE. - : Wiley-Blackwell. - 0022-1082 .- 1540-6261. ; 79:3, s. 2339-2390
-
Tidskriftsartikel (refereegranskat)abstract
- In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty-nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
|
|
| 6. |
|
|
| 7. |
- Björkman, Mats P., et al.
(författare)
-
Nitrate dry deposition in svalbard
- 2013
-
Ingår i: Tellus. Series B, Chemical and physical meteorology. - : Stockholm University Press. - 0280-6509 .- 1600-0889. ; 65, s. 19071-
-
Tidskriftsartikel (refereegranskat)abstract
- Arctic regions are generally nutrient limited, receiving an extensive part of their bio-available nitrogen from the deposition of atmospheric reactive nitrogen. Reactive nitrogen oxides, as nitric acid (HNO3) and nitrate aerosols (p-NO3), can either be washed out from the atmosphere by precipitation or dry deposited, dissolving to nitrate (NO3-). During winter, NO3- is accumulated in the snowpack and released as a pulse during spring melt. Quantification of NO3- deposition is essential to assess impacts on Arctic terrestrial ecology and for ice core interpretations. However, the individual importance of wet and dry deposition is poorly quantified in the high Arctic regions where in-situ measurements are demanding. In this study, three different methods are employed to quantify NO3- dry deposition around the atmospheric and ecosystem monitoring site, Ny-Alesund, Svalbard, for the winter season (September 2009 to May 2010): (1) A snow tray sampling approach indicates a dry deposition of -10.27 +/- 3.84 mg m(-2) (+/- S.E.); (2) A glacial sampling approach yielded somewhat higher values -30.68 +/- 12.00 mg m(-2); and (3) Dry deposition was also modelled for HNO3 and p-NO3 using atmospheric concentrations and stability observations, resulting in a total combined nitrate dry deposition of -10.76 +/- 1.26 mg m(-2). The model indicates that deposition primarily occurs via HNO3 with only a minor contribution by p-NO3. Modelled median deposition velocities largely explain this difference: 0.63 cm s(-1) for HNO3 while p-NO3 was 0.0025 and 0.16 cm s(-1) for particle sizes 0.7 and 7 mm, respectively. Overall, the three methods are within two standard errors agreement, attributing an average 14% (total range of 2-44%) of the total nitrate deposition to dry deposition. Dry deposition events were identified in association with elevated atmospheric concentrations, corroborating recent studies that identified episodes of rapid pollution transport and deposition to the Arctic.
|
|
| 8. |
- Chirico, Francesco, et al.
(författare)
-
Entrepreneurial Orientation, Generational Involvement and Participative Strategy: A Configurational Approach to Performance in Family Firms
- 2011
-
Ingår i: Academy of Management 2011 Annual Meeting. - New York : Academy of Management.
-
Konferensbidrag (refereegranskat)abstract
- To better understand the entrepreneurship in family firms, we consider the joint interaction effect of entrepreneurial orientation (EO), generational involvement and participative strategy. Drawing on the logic of resource orchestration, we argue that participative strategy acts as a coordinating mechanism that not only mitigates the relational conflict that increased generational involvement generates when mobilized EO, but also enhances family firms' ability to utilize the heterogeneous, yet complementary knowledge and experiences generational involvement offers. Configuring participative strategy and EO with generational involvement provides the direction and coordination needed to unlock the potential value of these unique resources. Our theory suggests that realizing the benefits from entrepreneurship in family firms is a complicated matter, affected by the configuration of EO, generational involvement and participative strategy.
|
|
| 9. |
- Chirico, Francesco, et al.
(författare)
-
Resource orchestration in family firms : Investigating how entrepreneurial orientation, generational involvement, and participative strategy affect performance
- 2011
-
Ingår i: Strategic Entrepreneurship Journal. - : John Wiley & Sons. - 1932-4391 .- 1932-443X. ; 5:4, s. 307-326
-
Tidskriftsartikel (refereegranskat)abstract
- Drawing on the process of resource orchestration, we argue a co-alignment of multiple factors is needed for family firms to increase performance through entrepreneurship. Specifically, we posit that entrepreneurial orientation provides the mobilizing vision to use the heterogeneous yet complementary knowledge and experiences offered by increased generational involvement toward entrepreneurship. However, without a coordinating mechanism, generational involvement leads to conflict and negative outcomes. When, instead, it is also coordinated via a participative strategy, performance gains are achieved. In sum, results suggest that realizing the benefits from entrepreneurship in family firms is a complicated matter affected by the synchronization of entrepreneurial orientation, generational involvement, and participative strategy. Copyright © 2011 Strategic Management Society.
|
|
| 10. |
- Krieger, Jonas A., et al.
(författare)
-
Weyl spin-momentum locking in a chiral topological semimetal
- 2024
-
Ingår i: Nature Communications. - 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Spin-orbit coupling in noncentrosymmetric crystals leads to spin-momentum locking – a directional relationship between an electron’s spin angular momentum and its linear momentum. Isotropic orthogonal Rashba spin-momentum locking has been studied for decades, while its counterpart, isotropic parallel Weyl spin-momentum locking has remained elusive in experiments. Theory predicts that Weyl spin-momentum locking can only be realized in structurally chiral cubic crystals in the vicinity of Kramers-Weyl or multifold fermions. Here, we use spin- and angle-resolved photoemission spectroscopy to evidence Weyl spin-momentum locking of multifold fermions in the chiral topological semimetal PtGa. We find that the electron spin of the Fermi arc surface states is orthogonal to their Fermi surface contour for momenta close to the projection of the bulk multifold fermion at the Γ point, which is consistent with Weyl spin-momentum locking of the latter. The direct measurement of the bulk spin texture of the multifold fermion at the R point also displays Weyl spin-momentum locking. The discovery of Weyl spin-momentum locking may lead to energy-efficient memory devices and Josephson diodes based on chiral topological semimetals.
|
|
