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- Kinnard, C., et al.
(författare)
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Climatic analysis of sea-ice variability in the Canadian Arctic from operational charts, 1980-2004
- 2006
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Ingår i: Annals of Glaciology. - : International Glaciological Society. - 0260-3055 .- 1727-5644. ; 44, s. 391-402
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Tidskriftsartikel (refereegranskat)abstract
- We present a complete climatic analysis of Sea-ice conditions in the Canadian Arctic based on digitized operational charts from the Canadian Ice Service for the period 1980–2004. The Seasonal climatology, Spatial variance and linear trends in total ice concentrations (CT) were calculated. The maximum reduction rate in CT was found in the Beaufort Sea (>24% decade–1) and in the Davis Strait/Labrador Sea region (>18% decade–1) during Spring and Summer. Empirical orthogonal function (EOF) analysis performed on monthly CT deviations yielded four Significant EOF modes explaining 32% of the total variance. The Spatial pattern, temporal behaviour and Seasonality of these four EOF modes are discussed and correlated with fields of Sea-level pressure, Surface winds, Surface air temperature and Sea-surface temperature monthly anomalies. These results point to the dominant influence of the North Atlantic Oscillation on CT decadal anomalies during the cold Season, while climate variability in the Pacific influences CT variations in the Beaufort Sea region during Spring–summer.
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- Zapotoczny, B, et al.
(författare)
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Tuning of Liver Sieve: The Interplay between Actin and Myosin Regulatory Light Chain Regulates Fenestration Size and Number in Murine Liver Sinusoidal Endothelial Cells
- 2022
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Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 23:17
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Tidskriftsartikel (refereegranskat)abstract
- Liver sinusoidal endothelial cells (LSECs) facilitate the efficient transport of macromolecules and solutes between the blood and hepatocytes. The efficiency of this transport is realized via transcellular nanopores, called fenestrations. The mean fenestration size is 140 ± 20 nm, with the range from 50 nm to 350 nm being mostly below the limits of diffraction of visible light. The cellular mechanisms controlling fenestrations are still poorly understood. In this study, we tested a hypothesis that both Rho kinase (ROCK) and myosin light chain (MLC) kinase (MLCK)-dependent phosphorylation of MLC regulates fenestrations. We verified the hypothesis using a combination of several molecular inhibitors and by applying two high-resolution microscopy modalities: structured illumination microscopy (SIM) and scanning electron microscopy (SEM). We demonstrated precise, dose-dependent, and reversible regulation of the mean fenestration diameter within a wide range from 120 nm to 220 nm and the fine-tuning of the porosity in a range from ~0% up to 12% using the ROCK pathway. Moreover, our findings indicate that MLCK is involved in the formation of new fenestrations—after inhibiting MLCK, closed fenestrations cannot be reopened with other agents. We, therefore, conclude that the Rho-ROCK pathway is responsible for the control of the fenestration diameter, while the inhibition of MLCK prevents the formation of new fenestrations.
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