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| 2. |
- Gustafson, Stefan, et al.
(författare)
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ICAM-1 is a cell-surface receptor for hyaluronan.
- 1995
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Ingår i: 6th Interscience World Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators, Geneva, Switzerland, 28-30 March, Abstract. ; 160, s. 28-
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Recension (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Gustafson, Stefan, et al.
(författare)
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Targeting of hyaluronan to tumours via binding to ICAM-1
- 1995
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Ingår i: 3rd International Workshop on Hyaluronan in Drug Delivery, Royal Society of Medicine Press, Round Table Series. ; 40
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Annan publikation (övrigt vetenskapligt/konstnärligt)
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| 6. |
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| 7. |
- Heinemeyer, Gerhard, et al.
(författare)
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Towards further harmonization of a glossary for exposure science-an ISES Europe statement
- 2022
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Ingår i: Journal of Exposure Science and Environmental Epidemiology. - : Springer Science and Business Media LLC. - 1559-0631 .- 1559-064X. ; 32:4, s. 526-529
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Tidskriftsartikel (refereegranskat)abstract
- The use of aligned exposure science terminology is crucial for ease of comparison and appropriate interpretation of exposure information, regulatory reports, and scientific publications. Sometimes the use of different terminology in different contexts and areas of exposure science results in diverging interpretations of the same descriptor. During the development of the European strategy for exposure science, the need was identified to agree on a defined terminology requiring an evaluation of the commonly used terms, synonymous uses, and their relationships between each other. This paper presents the first steps in compiling the most important exposure-related terms from existing guidance documents and publications for exposure and risk assessment and adapting them to be useful for different contexts and areas. This initial step is intended to trigger discussion on terminology among exposure scientists around the globe and across regulatory and methodological silos. The glossary itself is intended as a living document to be hosted by the International Society for Exposure Science.
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| 8. |
- McCourt, Peter A. G.
(författare)
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Hyaluronan receptors of liver endothelial cells, their purification and characterisation
- 1999
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Hyaluronan (HA) is a polysaccharide common throughout the connective tissues. and is found at low concentrations in the blood. The major site of its clearance is via an endocytic receptor on liver endothelial cells (LEC). This process is vital, as excessive serum levels of HA lead to clotting disorders and overly viscous blood. This thesis details studies towards the identification and characterisation of this receptor. A 100 kDa protein, previously identified as a candidate HA receptor on LEC using HA-Sepharose chromatography, was purified, sequenced and identified as ICAM-1. However, examination of its affinity for HA-Sepharose suggested that it actually interacted with blocked diaminohexane based linkers that would otherwise couple HA to Sepharose, and not with the HA itself. Furthermore, it was found that HA also had an affinity for the same blockedlinkers, and could displace ICAM-1 from them. The HA-binding moiety was identified as l-amino-6-acetoamidohexane, which may serve as a useful aid in the study of HA and its interactions with other bio-molecules.In the search for a means of purifying the LEC HA receptor, it was found that HA coupled to Sepharose via a shorter ethylenediamine based linker could specifically purify two HA binding proteins of approximately 200 and 400 kDa from the surface of LEC. These proteins were also found to have an affinity for scavenger receptor (SR) ligands, and have been purified on a large scale. Polyclonal antibodies to these proteins do not stain culturedhepatocytes, but do stain endocytic vesicles in cultured LEC, and specifically inhibit their uptake of HA and some scavenger receptor ligands. The potential role of the HA receptor in the clearance of SR ligands may have implications for diseases involving the pathological deposition of SR ligands.
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