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Sökning: WFRF:(McFarland HF)

  • Resultat 1-4 av 4
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1.
  • Bomprezzi, R, et al. (författare)
  • Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease
  • 2003
  • Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 12:17, s. 2191-2199
  • Tidskriftsartikel (refereegranskat)abstract
    • Multiple sclerosis (MS) and other T cell-mediated autoimmune diseases develop in individuals carrying a complex susceptibility trait, probably following exposure to various environmental triggers. Owing to the presumed weak influence of single genes on disease predisposition and the recognized genetic heterogeneity of autoimmune disorders in humans, candidate gene searches in MS have been difficult. In an attempt to identify molecular markers indicative of disease status rather than susceptibility genes for MS, we show that gene expression profiling of peripheral blood mononuclear cells by cDNA microarrays can distinguish MS patients from healthy controls. Our findings support the concept that the activation of autoreactive T cells is of primary importance for this complex organ-specific disorder and prompt further investigations on gene expression in peripheral blood cells aimed at characterizing disease phenotypes.
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2.
  • Polman, CH, et al. (författare)
  • Diagnostic criteria for multiple sclerosis: 2005 Revisions to the "McDonald Criteria"
  • 2005
  • Ingår i: Annals of Neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 58:6, s. 840-846
  • Tidskriftsartikel (refereegranskat)abstract
    • New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The "McDonald Criteria" have been extensively assessed and used since 2001. New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease. The 2005 Revisions to the McDonald Diagnostic Criteria for MS should simplify and speed diagnosis, whereas maintaining adequate sensitivity and specificity.
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3.
  • Niemi, MEK, et al. (författare)
  • 2021
  • swepub:Mat__t
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4.
  • Kanai, M, et al. (författare)
  • 2023
  • swepub:Mat__t
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  • Resultat 1-4 av 4

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