| 1. |
- Kanai, M, et al.
(författare)
-
- 2023
-
swepub:Mat__t
|
|
| 2. |
- Thoma, B, et al.
(författare)
-
An international, interprofessional investigation of the self-reported podcast listening habits of emergency clinicians: A METRIQ Study
- 2020
-
Ingår i: CJEM. - : Springer Science and Business Media LLC. - 1481-8043 .- 1481-8035. ; 22:1, s. 112-117
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectivesPodcasts are increasingly being used for medical education. A deeper understanding of usage patterns would inform both producers and researchers of medical podcasts. We aimed to determine how and why podcasts are used by emergency medicine and critical care clinicians.MethodsAn international interprofessional sample (medical students, residents, physicians, nurses, physician assistants, and paramedics) was recruited through direct contact and a multimodal social media (Twitter and Facebook) campaign. Each participant completed a survey outlining how and why they utilize medical podcasts. Recruitment materials included an infographic and study website.Results390 participants from 33 countries and 4 professions (medicine, nursing, paramedicine, physician assistant) completed the survey. Participants most frequently listened to medical podcasts to review new literature (75.8%), learn core material (75.1%), and refresh memory (71.8%). The majority (62.6%) were aware of the ability to listen at increased speeds, but most (76.9%) listened at 1.0 x (normal) speed. All but 25 (6.4%) participants concurrently performed other tasks while listening. Driving (72.3%), exercising (39.7%), and completing chores (39.2%) were the most common. A minority of participants used active learning techniques such as pausing, rewinding, and replaying segments of the podcast. Very few listened to podcasts multiple times.ConclusionsAn international cohort of emergency clinicians use medical podcasts predominantly for learning. Their listening habits (rarely employing active learning strategies and frequently performing concurrent tasks) may not support this goal. Further exploration of the impact of these activities on learning from podcasts is warranted.
|
|
| 3. |
- de Jong, S, et al.
(författare)
-
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
- 2018
-
Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 1, s. 163-
-
Tidskriftsartikel (refereegranskat)abstract
- Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Purcell, Shaun M., et al.
(författare)
-
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
- 2009
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 460:7256, s. 748-752
-
Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%(1,2). We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.
|
|
| 9. |
|
|
| 10. |
- Bennett, A. I., et al.
(författare)
-
Contact Measurements of Randomly Rough Surfaces
- 2017
-
Ingår i: Tribology letters. - : Springer Science and Business Media, LLC. - 1023-8883 .- 1573-2711. ; 65:4
-
Tidskriftsartikel (refereegranskat)abstract
- This manuscript presents an experimental effort to directly measure contact areas and the details behind these scaled experiments on a randomly rough model surface used in the “Contact Mechanics Challenge” (2017). For these experiments, the randomly rough surface model was scaled up by a factor of 1000× to give a 100 mm square sample that was 3D printed from opaque polymethylmethacrylate (PMMA). This sample was loaded against various optically smooth and transparent samples of PDMS that were approximately 15 mm thick and had a range in elastic modulus from 14 kPa to 2.1 MPa. During loading, a digital camera recorded contact locations by imaging the scattering of light that occurs off of the PMMA rough surface when it was in contact with the PDMS substrate. This method of illuminating contact areas is called frustrated total internal reflection and is performed by creating a condition of total internal reflection within the unperturbed PDMS samples. Contact or deformation of the surface results in light being diffusely transmitted from the PDMS and detected by the camera. For these experiments, a range of reduced pressure (nominal pressure/elastic modulus) from below 0.001 to over 1.0 was examined, and the resulting relative contact area (real area of contact/apparent area of contact) was found to increase from below 0.1% to over 60% at the highest pressures. The experimental uncertainties associated with experiments are discussed, and the results are compared to the numerical results from the simulation solution to the “Contact Mechanics Challenge.” The simulation results and experimental results of the relative contact areas as a function of reduced pressure are in agreement (within experimental uncertainties).
|
|
