| 1. |
- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 2. |
- Blokland, G. A. M., et al.
(författare)
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- 2022
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Ingår i: Biological Psychiatry. - : Elsevier BV. - 0006-3223 .- 1873-2402. ; 91:1, s. 102-117
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Tidskriftsartikel (refereegranskat)abstract
- Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10−6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels. © 2021 Society of Biological Psychiatry
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| 3. |
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| 4. |
- Matthaiou, Michail, 1981, et al.
(författare)
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Sum Rate Analysis of ZF Receivers in Distributed MIMO Systems
- 2013
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Ingår i: IEEE Journal on Selected Areas in Communications. - 0733-8716 .- 1558-0008. ; 31:2, s. 180-191
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Tidskriftsartikel (refereegranskat)abstract
- The performance of single-cell distributed multiple-input multiple-output (D-MIMO) systems is not only affected by small-scale Rayleigh fading but also from large-scale fading and path-loss. In this paper, we elaborate on the sum rate of D-MIMO systems employing linear zero-forcing receivers, accounting for both large and small-scale fading effects, as well as spatial correlation at the transmit side. In particular, we consider the classical lognormal model and propose closed-form upper and lower bounds on the achievable sum rate. Using these bounds as a starting point, we pursue a "large-system" analysis and provide asymptotic expressions when the number of antennas at the base station (BS) grow large, and when the number of antennas at both ends grow large with a fixed and finite ratio. A detailed characterization in the asymptotically high and low signal to noise ratio regimes is also provided. An interesting observation from our results is that in order to maximize the sum rate, the RPs should be placed at unequal distances to the BS when they experience the same level of shadowing. The resulting closed-form expressions are compared with the corresponding results on MIMO optimal receivers.
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| 5. |
- Matthaiou, Michail, 1981, et al.
(författare)
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Sum rate analysis of ZF receivers in distributed MIMO systems with Rayleigh/Lognormal fading
- 2012
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Ingår i: IEEE International Conference on Communications. - 1550-3607. - 9781457720529 ; , s. 3857-3861
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Konferensbidrag (refereegranskat)abstract
- This paper presents a detailed sum rate characterization of distributed multiple-input multiple-output systems operating over composite fading channels and employing linear zero-forcing receivers. We consider the Rayleigh/Lognormal fading model and also take into account the effects of path-loss and spatial correlation at the transmit side. New closed-form upper and lower bounds on the achievable sum rate are proposed that apply for arbitrary numbers of antennas. Moreover, we investigate the concept of large-scale multiple-antenna systems when the number of receive antennas grow large. In this asymptotic regime, it is shown that the effects of Rayleigh fading are averaged out and the channel is dominated by the much more slowly varying shadowing. An interesting observation from our results is that in order to maximize capacity, the radio ports should be placed at unequal distances to the base station when they experience the same level of shadowing.
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| 6. |
- Zhang, Y., et al.
(författare)
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Galaxies in X-ray selected clusters and groups in Dark Energy Survey data - II. Hierarchical Bayesian modelling of the red-sequence galaxy luminosity function
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 488:1, s. 1-17
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Tidskriftsartikel (refereegranskat)abstract
- Using similar to 100 X-ray selected clusters in the Dark Energy Survey Science Verification data, we constrain the luminosity function ( LF) of cluster red-sequence galaxies as a function of redshift. This is the first homogeneous optical/X-ray sample large enough to constrain the evolution of the LF simultaneously in redshift ( 0.1 < z < 1.05) and cluster mass ( 13.5 <= log(10)( M-200crit) similar to< 15.0). We pay particular attention to completeness issues and the detection limit of the galaxy sample. We then apply a hierarchical Bayesian model to fit the cluster galaxy LFs via a Schechter function, including its characteristic break ( m*) to a faint end power-law slope ( alpha). Our method enables us to avoid known issues in similar analyses based on stacking or binning the clusters. We find weak and statistically insignificant (similar to 1.9 sigma) evolution in the faint end slope alpha versus redshift. We also find no dependence in alpha or m* with the X-ray inferred cluster masses. However, the amplitude of the LF as a function of cluster mass is constrained to similar to 20 per cent precision. As a by-product of our algorithm, we utilize the correlation between the LF and cluster mass to provide an improved estimate of the individual cluster masses as well as the scatter in true mass given the X-ray inferred masses. This technique can be applied to a larger sample of X-ray or optically selected clusters from the Dark Energy Survey, significantly improving the sensitivity of the analysis.
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