| 1. |
- Hudson, Lawrence N, et al.
(författare)
-
The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
-
Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
-
Tidskriftsartikel (refereegranskat)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
|
|
| 2. |
- Alay, Özgü, et al.
(författare)
-
Monitoring and Analytics (Release B)
- 2021
-
Rapport (refereegranskat)abstract
- This document describes the design and implementation of the 5GENESIS Monitoring & Analytics (M&A) framework in its Release B, developed within Task T3.3 of the project work plan. M&A Release B leverages and extends M&A Release A, which has been documented in the previous Deliverable D3.5 [1]. In particular, we present new features and enhancements introduced in this new Release compared to the Release A. We also report some examples of usage of the M&A framework, in order to showcase its integrated in the 5GENESIS Reference Architecture.
|
|
| 3. |
- Pinese, Mark, et al.
(författare)
-
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
- 2020
-
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Population health research is increasingly focused on the genetic determinants of healthy ageing, but there is no public resource of whole genome sequences and phenotype data from healthy elderly individuals. Here we describe the first release of the Medical Genome Reference Bank (MGRB), comprising whole genome sequence and phenotype of 2570 elderly Australians depleted for cancer, cardiovascular disease, and dementia. We analyse the MGRB for single-nucleotide, indel and structural variation in the nuclear and mitochondrial genomes. MGRB individuals have fewer disease-associated common and rare germline variants, relative to both cancer cases and the gnomAD and UK Biobank cohorts, consistent with risk depletion. Age-related somatic changes are correlated with grip strength in men, suggesting blood-derived whole genomes may also provide a biologic measure of age-related functional deterioration. The MGRB provides a broadly applicable reference cohort for clinical genetics and genomic association studies, and for understanding the genetics of healthy ageing. Healthspan and healthy aging are areas of research with potential socioeconomic impact. Here, the authors present the Medical Genome Reference Bank (MGRB) which consist of over 4,000 individuals aged 70 years and older without a history of the major age-related diseases and report on results from whole-genome sequencing and association analyses.
|
|
| 4. |
- Rabitsch, Alexander, et al.
(författare)
-
Integrated Network and End-host Policy Management for Network Slicing
- 2022
-
Ingår i: The 18th International Conference on Network and Service Management (CNSM). - New York, USA : IEEE Communications Society.
-
Konferensbidrag (refereegranskat)abstract
- 5G mobile networks introduce the concept of network slicing, the functionality of creating virtual networks on top of shared physical infrastructure. Such slices can be tailored to various vertical services. A single User Equipment (UE) may be served by multiple network slice instances simultaneously, which opens up the possibility of dynamically steering traffic in response to the specific needs of individual applications -- and as a reaction to events inside the network, e.g., network failures. This paper presents the PoLicy-based Architecture for Network Slicing (PLANS). In this policy framework, the network slice management entity in the 5G core and the UE can cooperatively optimize the usage of the available network slices via policy systems installed both inside the network and on the UE. The PLANS architecture has been implemented and evaluated in a 5G testbed. For two different case studies, we show how such a system can be leveraged to provide optimized services and increased robustness against network failures. First, we consider a drone autopilot scenario, and demonstrate how PLANS can reduce network-slice recovery time by more than 90%. Second, we illustrate for a 360-degree video streaming scenario how PLANS can help prevent video quality degradation when a network slice becomes unavailable.
|
|
| 5. |
- Rabitsch, Alexander, et al.
(författare)
-
Integrated Network and End-host Policy Management for Network Slicing
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- 5G mobile networks introduce the concept of network slicing, the functionality of creating virtual networks on top of shared physical infrastructure. Such slices can be tailored to various vertical services. A single User Equipment (UE) may be served by multiple network slice instances simultaneously, which opens up the possibility of dynamically steering traffic in response to the specific needs of individual applications - and as a reaction to events inside the network, e.g., network failures. This paper presents the PoLicy-based Architecture for Network Slicing (PLANS). In this policy framework, the network slice management entity in the 5G core and the UE can cooperatively optimize the usage of the available network slices via policy systems installed both inside the network and on the UE. The PLANS architecture has been implemented and evaluated in a 5G testbed. For three different case studies, we show how such a system can be leveraged to provide optimized services and increased robustness against network failures. First, we consider a drone autopilot scenario and we demonstrate how PLANS can reduce network-slice recovery time by more than 90 %. We then study a bulk-transfer scenario and show how PLANS enables a sustained high throughput during a network-slice failure. Finally, for a 360-degree video streaming scenario, we illustrate how PLANS can help prevent video quality degradation due to a network-slice becoming unavailable.
|
|
| 6. |
- Sartelli, Massimo, et al.
(författare)
-
Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action
- 2023
-
Ingår i: WORLD JOURNAL OF EMERGENCY SURGERY. - 1749-7922. ; 18:1
-
Forskningsöversikt (refereegranskat)abstract
- Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or "golden rules," for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice.
|
|
