| 1. |
- Larik, Fayaz Ali, et al.
(författare)
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Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives
- 2017
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Ingår i: Steroids. - : Elsevier BV. - 0039-128X .- 1878-5867. ; 118, s. 76-92
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Forskningsöversikt (refereegranskat)abstract
- Spironolactone is a well-known multi-target drug and is specifically used for the treatment of high blood pressure and heart failure. It is also used for the treatment of edema, cirrhosis of the liver, malignant, pediatric, nephrosis and primary hyperaldosteronism. Spironolactone in association with thiazide diuretics treats hypertension and in association with furosemide treats bronchopulmonary dyspepsia. The therapeutic mechanism of action of spironolactone involves binding to intracellular mineralocorticoids receptors (MRs) in kidney epithelial cells, thereby inhibiting the binding of aldosterone. Since its first synthesis in 1957 there are several synthetic approaches have been reported throughout the years, Synthetic community has devoted efforts to improve the synthesis of spironolactone and to synthesize its analogues and derivatives. This review aims to provide comprehensive insight for the synthetic endeavors devoted towards the synthesis of a versatile drug spironolactone and its analogues/derivatives.
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| 2. |
- Larik, Fayaz Ali, et al.
(författare)
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The role of Lawesson's reagent in the total synthesis of macrocyclic natural products
- 2017
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Ingår i: Phosphorus Sulfur and Silicon and the Related Elements. - : TAYLOR & FRANCIS LTD. - 1042-6507 .- 1563-5325. ; 192:5, s. 490-502
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Forskningsöversikt (refereegranskat)abstract
- This review, including 111 references, describes the applications of Lawesson's reagent (LR) [2,4-bis(p-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-dithione] for the total synthesis of macrocyclic natural products. LR is a versatile reagent and shows excellent regioselectivity, chemoselectivity, and offers the products in high yield. The thionation of carbonyl moieties present in macrocyclic natural products, and cyclization to construct key heterocyclic fragments is described. Moreover, this review highlights the medicinal significance of the natural products. [GRAPHICS] .
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| 3. |
- Saeed, Aamer, et al.
(författare)
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Advances in transition-metal-catalyzed synthesis of 3-substituted isocoumarins
- 2017
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Ingår i: Journal of Organometallic Chemistry. - : ELSEVIER SCIENCE SA. - 0022-328X .- 1872-8561. ; 834, s. 88-103
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Forskningsöversikt (refereegranskat)abstract
- 3-Substituted isocoumarins are the most abundant class of naturally isocoumarins, found in several biologically active scaffolds and are precursors towards complex natural products. Considerable attempts have been devoted to the synthesis of these isocoumarins both by metal free or transition-metalcatalyzed reactions. Among the metal catalyzed reactions, the use of palladium, copper, gold, iron, nickel, rhodium, ruthenium, zinc, chromium, iridium, silver or thallium salts/complexes for the construction of 3-substituted isocoumarin ring is noteworthy due to being economical and good functional group tolerance. The current review focusses the recent reports on the Pd-, Cu-, Ag-, Fe-, Ni-, Rh-, Ru-, Zn, Cr-, Ir-, Ag- and Ti -catalyzed synthesis of isocoumarins.
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