| 1. |
- Iacopetta, B, et al.
(författare)
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Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.
- 2006
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Ingår i: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. - : Elsevier BV. - 0923-7534. ; 17:5, s. 842-7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Loss of TP53 function through gene mutation is a critical event in the development and progression of many tumour types including colorectal cancer (CRC). In vitro studies have found considerable heterogeneity amongst different TP53 mutants in terms of their transactivating abilities. The aim of this work was to evaluate whether TP53 mutations classified as functionally inactive (< or=20% of wildtype transactivation ability) had different prognostic and predictive values in CRC compared with mutations that retained significant activity. MATERIALS AND METHODS: TP53 mutations within a large, international database of CRC (n = 3583) were classified according to functional status for transactivation. RESULTS: Inactive TP53 mutations were found in 29% of all CRCs and were more frequent in rectal (32%) than proximal colon (22%) tumours (P < 0.001). Higher frequencies of inactive TP53 mutations were also seen in advanced stage tumours (P = 0.0003) and in tumours with the poor prognostic features of vascular (P = 0.006) and lymphatic invasion (P = 0.002). Inactive TP53 mutations were associated with significantly worse outcome only in patients with Dukes' stage D tumours (RR = 1.71, 95%CI 1.25-2.33, P < 0.001). Patients with Dukes' C stage tumours appeared to gain a survival benefit from 5-fluorouracil-based chemotherapy regardless of TP53 functional status for transactivation ability. CONCLUSIONS: Mutations that inactivate the transactivational ability of TP53 are more frequent in advanced CRC and are associated with worse prognosis in this stage of disease.
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| 3. |
- Craftman, Åsa, et al.
(författare)
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Home care assistants' attitudes and perceptions of caring for people at the end of life in their homes in Sweden
- 2022
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Ingår i: Health & Social Care in the Community. - : Hindawi Limited. - 0966-0410 .- 1365-2524. ; 30:5
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Tidskriftsartikel (refereegranskat)abstract
- The ageing population is increasing worldwide, with older people often having multimorbidity and a need for help with activities and personal care. Home Care Assistants (HCAs) are central to the provision of care in the home. They meet older people approaching the end of life and their relatives. Little is known about HCAs attitudes towards caring for a dying person and how aspects such as education, age, earlier care experiences, care education and experience of caring for dying older people affect their attitudes. The aim was to describe HCAs' attitudes towards the care of dying persons living in their ordinary homes. This cross-sectional study used the Frommelt Attitude Toward Care of the Dying Scale (FATCOD) for data collection during December 2017 and January 2018, and descriptive statistics and regression analysis for data analysis. The participants were HCAs (n = 127, 96% of those eligible) in a municipality in central Sweden. An overall positive attitude was reported. About 32% lacked formal HCA education although 93% had experience of interacting with a dying person. Age, HCA education, internal palliative care education, number of years' experience and previous experience of caring for a dying person were independently associated with HCAs' attitudes. In the multivariate regression analysis, age and years of experience were the only significant predictors of HCAs' attitudes towards caring for dying care recipients. Young employees without HCA education and experience of a dying person might be vulnerable in situations involving caring for a dying person. Communicating about death and dying, forming a relationship with the care recipient and the family, and providing care when a person is dying can be challenging. Implications: Young employees without HCA education and experience of interacting with a dying person needs to be prepared for the situation. This needs to be considered by stakeholders and social and healthcare organisations.
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| 6. |
- Mathiesen, T, et al.
(författare)
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Takanori Fukushima 1942 - 2024
- 2024
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Ingår i: Acta neurochirurgica. - 0942-0940. ; 166:1, s. 186-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Mossige, M., et al.
(författare)
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Time-aware test execution scheduling for cyber-physical systems
- 2019
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Ingår i: Lecture Notes in Informatics (LNI), Proceedings - Series of the Gesellschaft fur Informatik (GI). - : Gesellschaft fur Informatik (GI). - 9783885796862 ; , s. 121-122
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Konferensbidrag (refereegranskat)abstract
- The paper "Time-aware Test Execution Scheduling for Cyber-Physical Systems "first appeared in the application track of the 23rd International Conference on Principles and Practice of Constraint Programming (CP 2017). Testing cyber-physical systems involves the execution of test cases on target-machines equipped with the latest release of a software control system. When testing industrial robots, it is common that the target machines need to share some common resources, e.g., costly hardware devices, and so there is a need to schedule test case execution on the target machines, accounting for these shared resources. With a large number of such tests executed on a regular basis, this scheduling becomes difficult to manage manually. In fact, with manual test execution planning and scheduling, some robots may remain unoccupied for long periods of time and some test cases may not be executed. We introduce TC-Sched, a time-aware method for automated test case execution scheduling. TC-Sched uses Constraint Programming to schedule tests to run on multiple machines constrained by the tests' access to shared resources, such as measurement or networking devices. We will further discuss challenges and requirements encountered when automating testing for industrial robots.
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