| 1. |
- Wang, Zhaoming, et al.
(författare)
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Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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| 2. |
- Bousquet, Jean, et al.
(författare)
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ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
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Forskningsöversikt (refereegranskat)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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| 3. |
- Bousquet, J. Jean, et al.
(författare)
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Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases
- 2019
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Ingår i: Clinical and Translational Allergy. - : BMC. - 2045-7022 .- 2045-7022. ; 9
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Forskningsöversikt (refereegranskat)abstract
- Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy.Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care.Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
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| 4. |
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| 5. |
- Eberl, Jakob-Moritz, et al.
(författare)
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Media Framing Effects on Policy Preferences Towards Free Movement : A Comparative Approach
- 2019
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Konferensbidrag (refereegranskat)abstract
- In a time when freedom of movement is being challenged by an increasing number of European Union member states, and where immigration has been dominating public debate for the past years, this study investigates the effect of media framing (i.e., frame salience and frame sentiment) of migration news on individuals’ attitudes about free movement. Findings indicate that the salience of specific frames (i.e., labor market and security) as well as sentiment, positively influence free movement attitudes of citizens. However, there are country-specific differences. The importance of our findings for our understanding of media effects on policy preferences, as well as for comparative media effects research, are discussed.
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| 6. |
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| 7. |
- Eberl, Jakob-Moritz, et al.
(författare)
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The European Media Discourse on Immigration and Its Effects : A Literature Review
- 2018
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Ingår i: Annals of the International Communication Association. - New York : Routledge. - 2380-8985 .- 2380-8977. ; 42:3, s. 207-223
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Tidskriftsartikel (refereegranskat)abstract
- To understand public opinion about immigration in Europe, one has to understand the media’s role in it. We present a literature review on research on media discourse on immigration and their effects. Despite differences in the way immigration and migrant groups are represented in European media, we can observe common patterns. Migrants are generally under-represented and shown as delinquents or criminals. Although, media framing differs based on specific migrant groups the discourse is focusing on, immigration coverage is often negative and conflict-centred. Frequent exposure to such media messages leads to negative attitudes towards migration, may activate stereotypical cognitions of migrant groups, and even influence vote choice. In addition to discussing these issues in depth, the present review also focuses on comparative findings.
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| 8. |
- Hameleers, Michael, et al.
(författare)
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Mistakenly misinformed or intentionally deceived? Mis- and Disinformation perceptions on the Russian War in Ukraine among citizens in 19 countries
- 2023
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Ingår i: European Journal of Political Research. - 0304-4130.
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Tidskriftsartikel (refereegranskat)abstract
- In information environments characterized by institutional distrust, fragmentation and the widespread dissemination of conspiracies and disinformation, citizens perceive misinformation as a salient and threatening issue. Especially amidst disruptive events and crises, news users are likely to believe that information is inaccurate or deceptive. Using an original 19-country comparative survey study across diverse regions in the world (N = 19,037), we find that news users are likely to regard information on the Russian war in Ukraine as false. They are more likely to attribute false information to deliberative deception than to a lack of access to the war area or inaccurate expert knowledge. Russian sources are substantially more likely to be blamed for falsehoods than Ukrainian or Western sources – but these attribution biases depend on a country’s position on the war. Our findings reveal that people mostly believe that falsehoods are intended to deceive them, and selectively associate misinformation with the opposed camp.
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| 9. |
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| 10. |
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Media and Public Attitudes Toward Migration in Europe. A Comparative Approach
- 2021
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- This comparative volume provides a comprehensive cross-national account of media coverage and public attitudes toward migration both within and into the European Union. Using empirical research from across Germany, Hungary, Poland, Spain, Sweden, and the United Kingdom, Media and Public Attitudes Toward Migration in Europe offers an in-depth exploration of one of the most prominent social and political topics of the decade in Europe. Drawing on a large scale, cross-national panel survey, experiments, and media content analysis of migration discourse in both traditional news media and social media, expert contributors from across the continent investigate topics such as the linguistic features of migration coverage, the public perception of migrants, and the effects of journalistic communication strategies. Other topics addressed include a discussion of news framing effects on migration coverage and politicians’ postings on social media coverage about the issue. This is a valuable resource for academics, students, and policymakers interested in media coverage of migration, news framing effects, and public attitudes to migration generally.
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