| 1. |
- Librado, P., et al.
(författare)
-
The origins and spread of domestic horses from the Western Eurasian steppes
- 2021
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 598, s. 634-640
-
Tidskriftsartikel (refereegranskat)abstract
- Analysis of 273 ancient horse genomes reveals that modern domestic horses originated in the Western Eurasian steppes, especially the lower Volga-Don region. Domestication of horses fundamentally transformed long-range mobility and warfare(1). However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence of bridling, milking and corralling(2-4) at Botai, Central Asia around 3500 bc(3). Other longstanding candidate regions for horse domestication, such as Iberia(5) and Anatolia(6), have also recently been challenged. Thus, the genetic, geographic and temporal origins of modern domestic horses have remained unknown. Here we pinpoint the Western Eurasian steppes, especially the lower Volga-Don region, as the homeland of modern domestic horses. Furthermore, we map the population changes accompanying domestication from 273 ancient horse genomes. This reveals that modern domestic horses ultimately replaced almost all other local populations as they expanded rapidly across Eurasia from about 2000 bc, synchronously with equestrian material culture, including Sintashta spoke-wheeled chariots. We find that equestrianism involved strong selection for critical locomotor and behavioural adaptations at the GSDMC and ZFPM1 genes. Our results reject the commonly held association(7) between horseback riding and the massive expansion of Yamnaya steppe pastoralists into Europe around 3000 bc(8,9) driving the spread of Indo-European languages(10). This contrasts with the scenario in Asia where Indo-Iranian languages, chariots and horses spread together, following the early second millennium bc Sintashta culture(11,12).
|
|
| 2. |
|
|
| 3. |
- Olalde, I., et al.
(författare)
-
The Beaker phenomenon and the genomic transformation of northwest Europe
- 2018
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 555:7695, s. 190-196
-
Tidskriftsartikel (refereegranskat)abstract
- From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain's gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries.
|
|
| 4. |
- Angelopoulos, V., et al.
(författare)
-
First Results from the THEMIS Mission
- 2008
-
Ingår i: Space Science Reviews. - : Springer Science and Business Media LLC. - 0038-6308 .- 1572-9672. ; 141:1-4, s. 453-476
-
Forskningsöversikt (refereegranskat)abstract
- THEMIS was launched on February 17, 2007 to determine the trigger and large-scale evolution of substorms. During the first seven months of the mission the five satellites coasted near their injection orbit to avoid differential precession in anticipation of orbit placement, which started in September 2007 and led to a commencement of the baseline mission in December 2007. During the coast phase the probes were put into a string-of-pearls configuration at 100 s of km to 2 R-E along-track separations, which provided a unique view of the magnetosphere and enabled an unprecedented dataset in anticipation of the first tail season. In this paper we describe the first THEMIS substorm observations, captured during instrument commissioning on March 23, 2007. THEMIS measured the rapid expansion of the plasma sheet at a speed that is commensurate with the simultaneous expansion of the auroras on the ground. These are the first unequivocal observations of the rapid westward expansion process in space and on the ground. Aided by the remote sensing technique at energetic particle boundaries and combined with ancillary measurements and MHD simulations, they allow determination and mapping of space currents. These measurements show the power of the THEMIS instrumentation in the tail and the radiation belts. We also present THEMIS Flux Transfer Events (FTE) observations at the magnetopause, which demonstrate the importance of multi-point observations there and the quality of the THEMIS instrumentation in that region of space.
|
|
| 5. |
- Eastwood, J. P., et al.
(författare)
-
THEMIS observations of a hot flow anomaly : Solar wind, magnetosheath, and ground-based measurements
- 2008
-
Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 35:17, s. L17S03-
-
Tidskriftsartikel (refereegranskat)abstract
- The THEMIS spacecraft encountered a Hot Flow Anomaly ( HFA) on the dusk flank of the Earth's bow shock on 4 July 2007, observing it on both sides of the shock. Meanwhile, the THEMIS ground magnetometers traced the progress of the associated Magnetic Impulse Event along the dawn flank of the magnetosphere, providing a unique opportunity to study the transmission of the HFA through the shock and the subsequent downstream response. THEMIS-A, in the solar wind, observed classic HFA signatures. Isotropic electron distributions inside the upstream HFA are attributed to the action of the electron firehose instability. THEMIS-E, just downstream, observed a much more complex disturbance with the pressure perturbation decoupled from the underlying discontinuity. Simple calculations show that the pressure perturbation would be capable of significantly changing the magnetopause location, which is confirmed by the ground-based observations.
|
|
| 6. |
- Lui, A. T. Y., et al.
(författare)
-
Cluster observation of plasma flow reversal in the magnetotail during a substorm
- 2006
-
Ingår i: Annales Geophysicae. - 0992-7689 .- 1432-0576. ; 24:7, s. 2005-2013
-
Tidskriftsartikel (refereegranskat)abstract
- We investigate in detail a reversal of plasma flow from tailward to earthward detected by Cluster at the downstream distance of similar to 19 RE in the midnight sector of the magnetotail on 22 August 2001. This flow reversal was accompanied by a sign reversal of the B-z component and occurred during the late substorm expansion phase as revealed by simultaneous global view of auroral activity from IMAGE. We examine the associated Hall current system signature, current density, electric field, Lorentz force, and current dissipation/dynamo term, the last two parameters being new features that have not been studied previously for plasma flow reversals. It is found that (1) there was no clear quadrupole Hall current system signature organized by the flow reversal time, (2) the x-component of the Lorentz force did not change sign while the other two did, (3) the timing sequence of flow reversal from the Cluster configuration did not match tailward motion of a single plasma flow source, (4) the electric field was occasionally dawnward, producing a dynamo effect, and (5) the electric field was occasionally larger at the high-latitude plasma sheet than near the neutral sheet. These observations are consistent with the current disruption model for substorms in which these disturbances are due to shifting dominance of multiple current disruption sites and turbulence at the observing location.
|
|
| 7. |
- Schulz, S., et al.
(författare)
-
Classical and cubic Rashba effect in the presence of in-plane 4f magnetism at the iridium silicide surface of the antiferromagnet GdIr2Si2
- 2021
-
Ingår i: Physical Review B. - 2469-9950. ; 103:3
-
Tidskriftsartikel (refereegranskat)abstract
- We present a combined experimental and theoretical study of the two-dimensional electron states at the iridium-silicide surface of the antiferromagnet GdIr2Si2 above and below the Néel temperature. Using angle-resolved photoemission spectroscopy (ARPES) we find a significant spin-orbit splitting of the surface states in the paramagnetic phase. By means of ab initio density-functional-theory (DFT) calculations we establish that the surface electron states that reside in the projected band gap around the M¯ point exhibit very different spin structures which are governed by the conventional and the cubic Rashba effect. The latter is reflected in a triple spin winding, i.e., the surface electron spin reveals three complete rotations upon moving once around the constant energy contours. Below the Néel temperature, our ARPES measurements show an intricate photoemission intensity picture characteristic of a complex magnetic domain structure. The orientation of the domains, however, can be clarified from a comparative analysis of the ARPES data and their DFT modeling. To characterize a single magnetic domain picture, we resort to the calculations and scrutinize the interplay of the Rashba spin-orbit coupling field with the in-plane exchange field, provided by the ferromagnetically ordered 4f moments of the near-surface Gd layer.
|
|
| 8. |
- Alonso-Sáez, Laura, et al.
(författare)
-
Role for urea in nitrification by polar marine Archaea
- 2012
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 109:44, s. 17989-17994
-
Tidskriftsartikel (refereegranskat)abstract
- Despite the high abundance of Archaea in the global ocean, their metabolism and biogeochemical roles remain largely unresolved. We investigated the population dynamics and metabolic activity of Thaumarchaeota in polar environments, where these microorganisms are particularly abundant and exhibit seasonal growth. Thaumarchaeota were more abundant in deep Arctic and Antarctic waters and grew throughout the winter at surface and deeper Arctic halocline waters. However, in situ single-cell activity measurements revealed a low activity of this group in the uptake of both leucine and bicarbonate (<5% Thaumarchaeota cells active), which is inconsistent with known heterotrophic and autotrophic thaumarchaeal lifestyles. These results suggested the existence of alternative sources of carbon and energy. Our analysis of an environmental metagenome from the Arctic winter revealed that Thaumarchaeota had pathways for ammonia oxidation and, unexpectedly, an abundance of genes involved in urea transport and degradation. Quantitative PCR analysis confirmed that most polar Thaumarchaeota had the potential to oxidize ammonia, and a large fraction of them had urease genes, enabling the use of urea to fuel nitrification. Thaumarchaeota from Arctic deep waters had a higher abundance of urease genes than those near the surface suggesting genetic differences between closely related archaeal populations. In situ measurements of urea uptake and concentration in Arctic waters showed that small-sized prokaryotes incorporated the carbon from urea, and the availability of urea was often higher than that of ammonium. Therefore, the degradation of urea may be a relevant pathway for Thaumarchaeota and other microorganisms exposed to the low-energy conditions of dark polar waters.
|
|
| 9. |
- Kaczmarczyk, Lech, et al.
(författare)
-
Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9
- 2016
-
Ingår i: PLOS ONE. - San Francisco, United States : Public Library of Science. - 1932-6203. ; 11:4
-
Tidskriftsartikel (refereegranskat)abstract
- The mammalian prion protein (PrP, encoded by Prnp) is most infamous for its central role in prion diseases, invariably fatal neurodegenerative diseases affecting humans, food animals, and animals in the wild. However, PrP is also hypothesized to be an important receptor for toxic protein conformers in Alzheimer's disease, and is associated with other clinically relevant processes such as cancer and stroke. Thus, key insights into important clinical areas, as well as into understanding PrP functions in normal physiology, can be obtained from studying transgenic mouse models and cell culture systems. However, the Prnp locus is difficult to manipulate by homologous recombination, making modifications of the endogenous locus rarely attempted. Fortunately in recent years genome engineering technologies, like TALENs or CRISPR/Cas9 (CC9), have brought exceptional new possibilities for manipulating Prnp. Herein, we present our observations made during systematic experiments with the CC9 system targeting the endogenous mouse Prnp locus, to either modify sequences or to boost PrP expression using CC9-based synergistic activation mediators (SAMs). It is our hope that this information will aid and encourage researchers to implement gene-targeting techniques into their research program.
|
|
| 10. |
|
|
