| 1. |
- Celutkiene, Jelena, et al.
(författare)
-
Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies : a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC)
- 2020
-
Ingår i: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 22:9, s. 1504-1524
-
Tidskriftsartikel (refereegranskat)abstract
- Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed.
|
|
| 2. |
- Bucciarelli-Ducci, Chiara, et al.
(författare)
-
Cardiovascular disease in women : Insights from magnetic resonance imaging
- 2020
-
Ingår i: Journal of Cardiovascular Magnetic Resonance. - : Springer Science and Business Media LLC. - 1097-6647 .- 1532-429X. ; 22:1
-
Forskningsöversikt (refereegranskat)abstract
- The presentation and identification of cardiovascular disease in women pose unique diagnostic challenges compared to men, and underrecognized conditions in this patient population may lead to clinical mismanagement. This article reviews the sex differences in cardiovascular disease, explores the diagnostic and prognostic role of cardiovascular magnetic resonance (CMR) in the spectrum of cardiovascular disorders in women, and proposes the added value of CMR compared to other imaging modalities. In addition, this article specifically reviews the role of CMR in cardiovascular diseases occurring more frequently or exclusively in female patients, including Takotsubo cardiomyopathy, connective tissue disorders, primary pulmonary arterial hypertension and peripartum cardiomyopathy. Gaps in knowledge and opportunities for further investigation of sex-specific cardiovascular differences by CMR are also highlighted.
|
|
| 3. |
- Celma Tirado, Alberto, et al.
(författare)
-
Are preserved coastal water bodies in Spanish Mediterranean basin impacted by human activity? Water quality evaluation using chemical and biological analyses
- 2022
-
Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 165
-
Tidskriftsartikel (refereegranskat)abstract
- The Spanish Mediterranean basin is particularly susceptible to climate change and human activities, making it vulnerable to the influence of anthropogenic contaminants. Therefore, conducting comprehensive and exhaustive water quality assessment in relevant water bodies of this basin is pivotal. In this work, surface water samples from coastal lagoons or estuaries were collected across the Spanish Mediterranean coastline and subjected to target and suspect screening of 1,585 organic micropollutants by liquid chromatography coupled to ion mobility separation and high resolution mass spectrometry. In total, 91 organic micropollutants could be confirmed and 5 were tentatively identified, with pharmaceuticals and pesticides being the most prevalent groups of chemicals. Chemical analysis data was compared with data on bioanalysis of those samples (recurrent aryl hydrocarbon receptor (AhR) activation, and estrogenic receptor (ER) inhibition in wetland samples affected by wastewater streams). The number of identified organic contaminants containing aromatic rings could explain the AhR activation observed. For the ER antagonistic effects, predictions on estrogenic inhibition potency for the detected compounds were used to explain the activities observed. The integration of chemical analysis with bioanalytical observations allowed a comprehensive overview of the quality of the water bodies under study.
|
|
| 4. |
- Dürig, Wiebke, et al.
(författare)
-
Novel prioritisation strategies for evaluation of temporal trends in archived white-tailed sea eagle muscle tissue in non-target screening
- 2022
-
Ingår i: Journal of Hazardous Materials. - : Elsevier BV. - 0304-3894 .- 1873-3336. ; 424
-
Tidskriftsartikel (refereegranskat)abstract
- Environmental monitoring studies based on target analysis capture only a small fraction of contaminants of emerging concern (CECs) and miss pollutants potentially harmful to wildlife. Environmental specimen banks, with their archived samples, provide opportunities to identify new CECs by temporal trend analysis and nontarget screening. In this study, archived white-tailed sea eagle (Haliaeetus albicilla) muscle tissue was analysed by non-targeted high-resolution mass spectrometry. Univariate statistical tests (Mann-Kendall and Spearman rank) for temporal trend analysis were applied as prioritisation methods. A workflow for non-target data was developed and validated using an artificial time series spiked at five levels with gradient concentrations of selected CECs (n = 243). Pooled eagle muscle tissues collected 1965-2017 were then investigated with an eightpoint time series using the validated screening workflow. Following peak detection, peak alignment, and blank subtraction, 14 409 features were considered for statistical analysis. Prioritisation by time-trend analysis detected 207 features with increasing trends. Following unequivocal molecular formula assignment to prioritised features and further elucidation with MetFrag and EU Massbank, 13 compounds were tentatively identified, of which four were of anthropogenic origin. These results show that it is possible to prioritise new CECs in archived biological samples using univariate statistical approaches.
|
|
| 5. |
- Menger, Frank, et al.
(författare)
-
Beyond the Tip of the Iceberg: Suspect Screening Reveals Point Source-Specific Patterns of Emerging and Novel Per- and Polyfluoroalkyl Substances in German and Chinese Rivers br
- 2022
-
Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 56, s. 5456-5465
-
Tidskriftsartikel (refereegranskat)abstract
- Only a few dozens of the several thousand existing per- and polyfluoroalkyl substances (PFAS) are monitored usingconventional target analysis. This study employed suspectscreening to examine patterns of emerging and novel PFAS inGerman and Chinese river water affected by industrial pointsources. In total, 86 PFAS were (tentatively) identified andgrouped into 18 structure categories. Homologue patterns revealeddistinct differences betweenfluoropolymer production sites of thetwo countries. In the Chinese Xiaoqing River Basin, the C8homologue was the most prevalent compound of the emergingseries of chlorinated perfluoroalkyl carboxylic acids (Cl-PFCAs)and perfluoroalkylether carboxylic acids (PFECAs). In contrast, C6and shorter homologues were dominant in the German Alz River.This indicates that the phaseout of long-chain compounds in Europe and their ongoing production in Asian countries also apply tounregulated emerging PFAS classes. Additional characteristics to differentiate the point sources were the peak area ratio ofperfluorobutane sulfonic acid (PFBS) versus the emerging compound hydro-substituted PFBS (H-PFBS) as well as the occurrenceof byproducts of the sulfonated tetrafluoroethylene-based polymer Nafion. The large number of identified unregulated PFASunderlines the importance of a grouping approach on a regulatory level, whereas the revealed contamination patterns can be used toestimate, prioritize, and minimize contributions of specific sources
|
|
| 6. |
- Menger, Frank, et al.
(författare)
-
Enhancing spectral quality in complex environmental matrices: Supporting suspect and non-target screening in zebra mussels with ion mobility
- 2022
-
Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 170
-
Tidskriftsartikel (refereegranskat)abstract
- Identification of bioaccumulating contaminants of emerging concern (CECs) via suspect and non-target screening remains a challenging task. In this study, ion mobility separation with high-resolution mass spectrometry (IM-HRMS) was used to investigate the effects of drift time (DT) alignment on spectrum quality and peak annotation for screening of CECs in complex sample matrices using data independent acquisition (DIA). Data treatment approaches (Binary Sample Comparison) and prioritisation strategies (Halogen Match, co-occurrence of features in biota and the water phase) were explored in a case study on zebra mussel (Dreissena polymorpha) in Lake Ma center dot laren, Sweden's largest drinking water reservoir. DT alignment evidently improved the fragment spectrum quality by increasing the similarity score to reference spectra from on average (+/- standard deviation) 0.33 +/- 0.31 to 0.64 +/- 0.30 points, thus positively influencing structure elucidation efforts. Thirty-two features were tenta-tively identified at confidence level 3 or higher using MetFrag coupled with the new PubChemLite database, which included predicted collision cross-section values from CCSbase. The implementation of predicted mobility data was found to support compound annotation. This study illustrates a quantitative assessment of the benefits of IM-HRMS on spectral quality, which will enhance the performance of future screening studies of CECs in complex environmental matrices.
|
|
| 7. |
- Menger, Frank
(författare)
-
Hidden in the Water : Development of screening strategies to identify new organic contaminants of emerging concern
- 2021
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Man-made chemicals enable and sustain our modern quality of life. These chemicals can, however, become contaminants of emerging concern (CECs). There is currently a considerable lag time between release of chemicals to the environment and their identification as CECs. In fact, many CECs may already be present in the environment but have not been identified. High-resolution mass spectrometry (HRMS) is currently the technique of choice to identify new CECs. In this thesis, efforts were made to reduce the lag time between release and detection by developing new screening strategies for identification of CECs using HRMS. In an initial critical review of the literature on existing HRMS-based water screening strategies, knowledge gaps on sampling approaches, data processing and prioritisation strategies were identified. Liquid chromatography-HRMS was then used to (tentatively) identify different potential CECs in the Swedish aquatic environment, particularly organohalogen compounds and pesticide transformation products in different time-integrated water samples and bioaccumulating compounds in zebra mussels (Dreissena polymorpha). Structural information on e.g. characteristic isotopic profiles and structural relation to known pollutants, combined with new forms of metadata and ion mobility separation, proved to be powerful tools for identification of new potential CECs.The new strategies for identification of novel CECs presented in this thesis improve our understanding of CECs in the aquatic environment.
|
|
| 8. |
- Menger, Frank, et al.
(författare)
-
Identification of Pesticide Transformation Products in Surface Water Using Suspect Screening Combined with National Monitoring Data
- 2021
-
Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 55, s. 10343-10353
-
Tidskriftsartikel (refereegranskat)abstract
- Pesticides are widespread anthropogenic chemicals and well-known environmental contaminants of concern. Much less is known about transformation products (TPs) of pesticides and their presence in the environment. We developed a novel suspect screening approach for not well-explored pesticides (n = 16) and pesticide TPs (n = 242) by integrating knowledge from national monitoring with high-resolution mass spectrometry data. Weekly time-integrated samples were collected in two Swedish agricultural streams using the novel Time-Integrating, MicroFlow, In-line Extraction (TIMFIE) sampler. The integration of national monitoring data in the screening approach increased the number of prioritized compounds approximately twofold (from 23 to 42). Ultimately, 11 pesticide TPs were confirmed by reference standards and 12 TPs were considered tentatively identified with varying levels of confidence. Semiquantification of the newly confirmed TPs indicated higher concentrations than their corresponding parent pesticides in some cases, which highlights concerns related to (unknown) pesticide TPs in the environment. Some TPs were present in the environment without co-occurrence of their corresponding parent compounds, indicating higher persistency or mobility of the identified TPs. This study showcased the benefits of integrating monitoring knowledge in this type of studies, with advantages for suspect screening performance and the possibility to increase relevance of future monitoring programs.
|
|
| 9. |
- Menger, Frank, et al.
(författare)
-
Review and analysis of PMT substances in water
- 2022
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med den här studien var att studera förekomst av persistenta, mobila organiska miljöföroreningar (PMOC) i svensk vattenmiljö med fokus på risk för förorening av dricksvatten. Kända punktkällor och råvatten för dricksvattenproduktion i Mälarens närområde provtogs och analyserades med hjälp av högupplöst masspektrometeri (HRMS). Avrinning från flygplatser (n = 2), dagvatten (n = 7), lakvatten från deponier (n = 9) avloppsvatten från reningsverk (n = 15) och råvatten för dricksvattenproduktion (n = 3) ingick i studien och analyserades med metoder speciellt anpassade för mobila (polära) ämnen. Screeningen utgick från listor av tänkbara föroreningar som tagits fram genom in silico metoder och omfattade totalt 249 ämnen. Åtta PMOCs bekräftades och 24 identifierades (preliminärt) i vatten från punktkällor och/eller dricksvatten. Varje (preliminärt) identifierad substans som upptäcktes i råvatten återfanns även i flera typer av de påverkade miljöproverna (punktkällorna). De (preliminärt) identifierade substanserna bör undersökas vidare med avseende på ursprung och förekomst i miljön samt bedömas utifrån potentiella risker för miljön och som föroreningar i dricksvatten.
|
|
| 10. |
- Menger, Frank, et al.
(författare)
-
Suspect screening based on market data of polar halogenated micropollutants in river water affected by wastewater
- 2021
-
Ingår i: Journal of Hazardous Materials. - : Elsevier BV. - 0304-3894 .- 1873-3336. ; 401
-
Tidskriftsartikel (refereegranskat)abstract
- Wastewater treatment plants (WWTPs) are known point sources of contaminants of emerging concern (CECs) to the aquatic environment, but current knowledge is mostly limited to well-known chemical structures. In this study, we sought to identify unknown CECs polluting the aquatic environment through a novel suspect screening approach for organohalogens, i.e. organic halogenated molecules often toxic and resistant to transformation and characterised as persistent organic pollutants (POPs). Surface water samples were collected with passive samplers in the Fyris River catchment (Uppsala, Sweden), analysed using liquid chromatography high-resolution mass spectrometry (LC-HRMS) and screened for organohalogens using a suspect screening approach based on market data obtained from a regulatory authority. Thirteen suspects from very different application areas were confirmed or tentatively identified with high confidence, including seven previously unknown structures (diflufenican, chlorzoxazone, 3-(3,4-dichlorophenyl)-1,1-dimethylurea, 2,4-disulfamyl-5-trifluoromethylaniline, 5-amino-2-chlorotoluene-4-sulfonic acid, perfluoropentane-1-sufonic acid, (2-chlorophenyl)(hydroxy)methanesulfonic acid). Spatiotemporal occurrence patterns were detected, which helped to understand the usage pattern of the chemicals and pinpoint potential pollution sources, e.g. specific WWTPs in the catchment. Several of the newly identified structures had virtually no information publicly available and were detected years after their last registered use, which highlights the knowledge gaps and concerns about POPs.
|
|
