| 1. |
- Engel, J., et al.
(författare)
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Mechanistic Insights into the Iridium-Catalyzed Hydrogenations of alpha,beta-Unsaturated Ketones
- 2016
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Ingår i: Chemcatchem. - : Wiley. - 1867-3880. ; 8:19, s. 3099-3106
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Tidskriftsartikel (refereegranskat)abstract
- The highly enantioselective hydrogenation of linear enones catalyzed by Ir complexes that bear a chiral P,N ligand have been investigated computationally. Compared to the results of previous studies, the mechanism is different because of the coordination of the substrate. In the favored pathway Ir stays in the +3 oxidation state throughout the entire catalytic cycle, the olefinic group is coordinated trans to the ligand N atom, and the carbonyl group binds trans to a spectator hydride. After migratory insertion, a H-2 coordinates and delivers the second H atom by sigma-metathesis. The calculated path rationalizes the observed enantioselectivities and allows the development of a predictive quadrant model for this class of substrate-ligand combination.
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| 2. |
- Rossaint, J, et al.
(författare)
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Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education
- 2021
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 218:7
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Tidskriftsartikel (refereegranskat)abstract
- Beyond hemostasis, platelets actively participate in immune cell recruitment and host defense, yet their potential in the resolution of inflammatory processes remains unknown. Here, we demonstrate that platelets are recruited into the lung together with neutrophils during the onset of inflammation and alongside regulatory T (T reg) cells during the resolution phase. This partnering dichotomy is regulated by differential adhesion molecule expression during resolution. Mechanistically, intravascular platelets form aggregates with T reg cells, a prerequisite for their recruitment into the lung. This interaction relies on platelet activation by sCD40L and platelet P-selectin binding to PSGL-1 on T reg cells. Physical platelet–T reg cell interactions are necessary to modulate the transcriptome and instruct T reg cells to release the anti-inflammatory mediators IL-10 and TGFβ. Notably, the presence of platelet–T reg cell aggregates in the lung was also required for macrophage transcriptional reprogramming, polarization toward an anti-inflammatory phenotype, and effective resolution of pulmonary inflammation. Thus, platelets partner with successive immune cell subsets to orchestrate both the initiation and resolution of inflammation.
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