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Sökning: WFRF:(Meschke J. S.)

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1.
  • Munk, P., et al. (författare)
  • Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
  • 2022
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
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2.
  • Gasparinetti, S., et al. (författare)
  • Fast Electron Thermometry for Ultrasensitive Calorimetric Detection
  • 2015
  • Ingår i: Physical Review Applied. - 2331-7019. ; 3:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We demonstrate radio-frequency thermometry on a micrometer-sized metallic island below 100 mK. Our device is based on a normal-metal-insulator-superconductor tunnel junction coupled to a resonator with transmission readout. In the first generation of the device, we achieve 90 mu K/root Hz noise-equivalent temperature with 10 MHz bandwidth. We measure the thermal relaxation time of the electron gas in the island, which we find to be of the order of 100 mu s. Such a calorimetric detector, upon optimization, can be seamlessly integrated into superconducting circuits, with immediate applications in quantum-thermodynamics experiments down to single quanta of energy.
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