| 1. |
- Casolino, M., et al.
(författare)
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Cosmic ray measurements with Pamela experiment
- 2009
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Konferensbidrag (refereegranskat)abstract
- PAMELA is a satellite borne experiment designed to study with great accuracy cosmic rays of galactic, solar, and trapped nature hi a wide energy range (protons: 80 MeV-700 GeV, electrons 50 MeV-400 GeV). Main objective is the study of the antimatter component: antiprotons (80 MeV-190 GeV), positrons (50 MeV-270 GeV) and search for antinuclei with a precision of the order of 10(-8)). The experiment, housed on board the Russian Resurs-DK1 satellite, was launched on June, 15(th) 2006 in a 350 X 600 km orbit with an inclination of 70 degrees. In this work we describe the scientific objectives awl the performance of PAMELA in its first two years of operation. Data oil protons of trapped, secondary and galactic nature - as well as measurements of the December 13(th) 2006 Solar Particle Event - are also provided.
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| 2. |
- Bramsen, Jesper B., et al.
(författare)
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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
- 2009
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Ingår i: Nucleic Acids Research. - : Oxford University Press. - 0305-1048 .- 1362-4962. ; 37:9, s. 2867-2881
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Tidskriftsartikel (refereegranskat)abstract
- The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is expectably required for successful application in vivo. Several studies have aimed at improving siRNA performance through the introduction of chemical modifications but a direct comparison of these results is difficult. We have directly compared the effect of 21 types of chemical modifications on siRNA activity and toxicity in a total of 2160 siRNA duplexes. We demonstrate that siRNA activity is primarily enhanced by favouring the incorporation of the intended antisense strand during RNA-induced silencing complex (RISC) loading by modulation of siRNA thermodynamic asymmetry and engineering of siRNA 3'-overhangs. Collectively, our results provide unique insights into the tolerance for chemical modifications and provide a simple guide to successful chemical modification of siRNAs with improved activity, stability and low toxicity.
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| 3. |
- Mikhailov, Sergey A, et al.
(författare)
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Microwave response of a two-dimensional electron stripe
- 2005
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 71§:3, s. 035320-
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Tidskriftsartikel (refereegranskat)abstract
- Electromagnetic response of a finite-width two-dimensional electron stripe is theoretically studied. It is shown that retardation and radiative effects substantially modify the absorption spectrum of the system at microwave frequencies, leading to a nontrivial zigzag behavior of the magnetoplasmon-polariton modes in magnetic fields, similar to that recently observed by Kukushkin [Phys. Rev. Lett. 90, 156801 (2003)].
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| 4. |
- Mikhailov, Sergey, et al.
(författare)
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Influence of contacts on the microwave response of a two-dimensional electron stripe
- 2006
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 74:4
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Tidskriftsartikel (refereegranskat)abstract
- Electromagnetic response of a finite-width two-dimensional electron stripe with attached metallic side contacts is theoretically studied. It is shown that contacts substantially influence the position, the linewidth, and the amplitude of plasmon-polariton resonances in the stripe. In finite magnetic fields, absorption of the wave with the inactive circular polarization (which is not absorbed in an infinite system without contacts) may become larger than that of the wave with the active polarization. The results are discussed in view of recent microwave experiments in two-dimensional electron systems.
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| 5. |
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