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| 2. |
- Bousquet, Jean, et al.
(författare)
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ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
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Forskningsöversikt (refereegranskat)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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| 3. |
- Chhor, Vibol, et al.
(författare)
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Role of microglia in a mouse model of paediatric traumatic brain injury.
- 2017
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Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 1090-2139 .- 0889-1591. ; 63, s. 197-209
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Tidskriftsartikel (refereegranskat)abstract
- The cognitive and behavioural deficits caused by traumatic brain injury (TBI) to the immature brain are more severe and persistent than TBI in the mature brain. Understanding this developmental sensitivity is critical as children under four years of age sustain TBI more frequently than any other age group. Microglia (MG), resident immune cells of the brain that mediate neuroinflammation, are activated following TBI in the immature brain. However, the type and temporal profile of this activation and the consequences of altering it are still largely unknown. In a mouse model of closed head weight drop paediatric brain trauma, we characterized i) the temporal course of total cortical neuroinflammation and the phenotype of ex vivo isolated CD11B-positive microglia/macrophage (MG/MΦ) using a battery of 32 markers, and ii) neuropathological outcome 1 and 5days post-injury. We also assessed the effects of targeting MG/MΦ activation directly, using minocycline a prototypical microglial activation antagonist, on these processes and outcome. TBI induced a moderate increase in both pro- and anti-inflammatory cytokines/chemokines in the ipsilateral hemisphere. Isolated cortical MG/MΦ expressed increased levels of markers of endogenous reparatory/regenerative and immunomodulatory phenotypes compared with shams. Blocking MG/MΦ activation with minocycline at the time of injury and 1 and 2days post-injury had only transient protective effects, reducing ventricular dilatation and cell death 1day post-injury but having no effect on injury severity at 5days. This study demonstrates that, unlike in adults, the role of MG/MΦ in injury mechanisms following TBI in the immature brain may not be negative. An improved understanding of MG/MΦ function in paediatric TBI could support translational efforts to design therapeutic interventions.
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| 4. |
- Rezaei, Fatemeh, et al.
(författare)
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Water uptake and permeability in sapwood and heartwood of hydro-thermally proceed Turkey oak
- 2024
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Ingår i: Wood Material Science & Engineering. - : Taylor & Francis. - 1748-0272 .- 1748-0280.
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to investigate the combined effect of steaming and heating on the equilibrium moisture content (EMC) of Turkey oak (Quercus cerris L.) wood over a nine-year period. The study also aimed to determine the impact of steaming on water absorption and water permeability, crucial for the durability of the species against environmental factors. The specimens underwent thermal modification with and without steaming, then were stored under laboratory conditions for ten years. The mass of the specimens was monitored throughout the ten-year period. To measure the water uptake capacity, the specimens were soaked in water for 120 hours. The water permeability of the specimens was assessed using a pressurised chamber. The results showed that the moisture content of thermally-modified oak was constant under laboratory conditions after nine years, further improved by steam treatment. The research also revealed that the steamed wood absorbed more water during water submersion compared to the unmodified wood. When the steaming treatment was applied, there was a significant increase in permeability in the sapwood compared to the heartwood, due to anatomical variations. Despite this, statistical noise, and material variability, alongside tylosis presence, underline the need for examining more specimens in future studies.
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| 5. |
- Zlatkovikj, Milan, et al.
(författare)
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Development of feed-forward model predictive control for applications in biomass bubbling fluidized bed boilers
- 2022
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Ingår i: Journal of Process Control. - : ELSEVIER SCI LTD. - 0959-1524 .- 1873-2771. ; 115, s. 167-180
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Tidskriftsartikel (refereegranskat)abstract
- In order to accommodate more intermittent renewable energy sources, biomass fueled combined heat and power plants (bio-CHPs) can contribute towards sustainable and flexible energy systems. However, the varying properties of biomass, such as moisture contents and heating values, can clearly affect the combustion in boilers, which further affects the flexibility provided by bio-CHPs. In order to achieve better control, this paper proposes a feed-forward model predictive controller (FF MPC) to handle the variation of biomass properties. A dynamic model was built in Dymola to simulate the performance of a bubbling fluidized bed boiler, which was validated against the real operation data. Based on the simulation, the key manipulated variables were optimized for the given controlled variables. The advantages of the proposed FF MPC were demonstrated through comparisons with proportional- integral (PI), FF PI and MPC. The results of FF MPC show the best performance, such as the lowest magnitude of fluctuations for 3 outputs (thermal load, steam and fluidized bed temperature), and the most stable operation. Consequently, FF MPC can potentially increase the electricity generation and further lead to an economic benefit. Using one week in winter as an example, compared to PI, FF PI and MPC, FF MPC can generate more electricity and improve revenues by 14.77 MWh/590 =C, 4.1 MWh/164 =C and 5.03 MWh/211.2 =C respectively.
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| 6. |
- Zlatkovikj, Milan, et al.
(författare)
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Influence of fuel properties on the performance of the feed forward model predictive control (FF MPC) for biomass boilers
- 2023
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Ingår i: Energy Proceedings. - : Scanditale AB. - 2004-2965. ; 32, s. 1-6
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Tidskriftsartikel (refereegranskat)abstract
- The growing share of renewable energy sources drives the need for increased flexibility in the energy systems. The flexibility provision from thermal plants is limited by the boiler’s thermal inertia as a bottleneck. Advanced controllers, such as model predictive control (MPC), have been identified as potential flexibility enablers. Fuel properties are crucial input for controllers. This work investigated the feasibility of using the properties obtained online by using near infrared spectroscopy based soft sensor to further improve the control performance. The performance of the existing proportional integral (PI) controller is compared with those of 2 feed forward (FF) MPC controllers. Both FF MPCs have significant improvement compared to PI controller and the FF MPC based on the full elemental composition shows the best performance due to more complete fuel information. There is a potential for revenues improvement with advanced control up to 1050 euros for one operation day.
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| 7. |
- Zlatkovikj, Milan, et al.
(författare)
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Influence of the transient operation of a large-scale thermal energy storage system on the flexibility provided by CHP plants
- 2023
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Ingår i: e-Prime - Advances in Electrical Engineering, Electronics and Energy. - : Elsevier Ltd. - 2772-6711. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Among many technical options to improve the flexibility in combined heat and power (CHP) plants, thermal energy storage (TES) has attracted the most attention with its high applicability and benefit. Previous studies normally adopted a simplified approach for modelling a TES system, which assumes the optimized charged or discharged rate of heat can always be realized within the rated capacity. However, this may yield unfeasible results as the charging and discharging rates are dependent on the dynamic status of a TES, such as the state of charge (SOC) and water temperature, and the water flowrate for charging and discharging. In order to consider the transient operation of a TES, a 1D dynamic model was developed and validated against measured data from a real CHP plant. To analyze the dynamic performance of a TES, two key performance indicators (KPI), the maximum charging/discharging rate (C/D-ratemax) and the constant maximum charging/discharging rate that can be maintained constantly for one hour (CC/CD-ratemax) were employed. By doing simulations, it has been found that the CC/CD-ratemax was lower than the C/D-ratemax for most given SOCs of the studied TES. The developed model was also used to examine the optimized operation of a TES for providing flexibility. Some unfeasible results have been identified, as the optimized hourly charging/discharging rates were constrained by the CC/CD-ratemax. Therefore, it is of great importance to integrate a detailed dynamic model when optimizing the dispatch of electricity and heat for a CHP plant.
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