| 1. |
- Ademuyiwa, Adesoji O., et al.
(författare)
-
Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
-
Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
|
|
| 2. |
- Dennis, Martin, et al.
(författare)
-
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS) : a pragmatic, double-blind, randomised, controlled trial
- 2019
-
Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 393:10168, s. 265-274
-
Tidskriftsartikel (refereegranskat)abstract
- Background Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.Methods FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762.Findings Between Sept 10,2012, and March 31,2017,3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99.3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0.951 [95% CI 0.839-1.079]; p=0.439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13.43%] patients vs 269 [17.21%]; difference 3.78% [95% CI 1.26-6.30]; p=0.0033), but they had more bone fractures (45 [2.88%] vs 23 [1.47%]; difference 1.41% [95% CI 0.38-2.43]; p=0.0070). There were no significant differences in any other event at 6 or 12 months.Interpretation Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function.
|
|
| 3. |
- Milligan, Tony, et al.
(författare)
-
Afterword
- 2018
-
Ingår i: Astrobiology and Society in Europe Today. - Cham : Springer International Publishing. - 9783319962641 - 9783319962658 ; , s. 55-60
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 4. |
- Milligan, Tony, et al.
(författare)
-
Introduction
- 2018
-
Ingår i: Astrobiology and Society in Europe Today. - Cham : Springer International Publishing. - 9783319962641 - 9783319962658 ; , s. 1-6
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 5. |
- Dunér, David, et al.
(författare)
-
Astrobiology and Society in Europe
- 2018
-
Ingår i: Astrobiology and Society in Europe Today. - Cham : Springer International Publishing. - 9783319962641 ; , s. 7-10
-
Bokkapitel (refereegranskat)
|
|
| 6. |
- Dunér, David, et al.
(författare)
-
Education, Training and Scholarship
- 2018
-
Ingår i: Astrobiology and Society in Europe Today. - Cham : Springer International Publishing. - 9783319962641 ; , s. 31-35
-
Bokkapitel (refereegranskat)
|
|
| 7. |
- Dunér, David, et al.
(författare)
-
Society, Worldview and Outreach
- 2018
-
Ingår i: Astrobiology and Society in Europe Today. - Cham : Springer International Publishing. - 9783319962641 - 9783319962658 ; , s. 19-24
-
Bokkapitel (refereegranskat)
|
|
| 8. |
- Persson, Erik, et al.
(författare)
-
Environment and Sustainability
- 2018
-
Ingår i: Astrobiology and Society in Europe Today. - Cham : Springer International Publishing. - 2191-9119 .- 2191-9100. - 9783319962641 - 9783319962658 ; , s. 25-30
-
Bokkapitel (refereegranskat)abstract
- There are strong links between astrobiology and environmental concern. Astrobiology is the study of the origin, evolution and distribution of life in the universe—including Earth. Understanding life, and in particular the basic conditions for life, is important for our ability to create a sustainable future on Earth. The connection goes both ways, however. The preservation of biodiversity and of pristine environments on Earth is of the greatest importance for our ability to study life, its origin, distribution and future. Of special interest from an astrobiology perspective is the preservation of areas with conditions that can serve as analogues to extraterrestrial environments, areas with conditions similar to those under which life originated on Earth, and in general environments where extreme adaptations can be studied. Astrobiology also presents some direct environmental challenges that need to be considered, namely in the form of forward and back contamination (discussed above in 2.3). Both issues need to be approached from a technical perspective, but also from a societal perspective. And both must be understood within a broader context of ensuring the sustainability of practices, both scientific and commercial.
|
|
| 9. |
- Prusti, T., et al.
(författare)
-
The Gaia mission
- 2016
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 595
-
Tidskriftsartikel (refereegranskat)abstract
- Gaia is a cornerstone mission in the science programme of the European Space Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia was launched on 19 December 2013 and arrived at its operating point, the second Lagrange point of the Sun-Earth-Moon system, a few weeks later. The commissioning of the spacecraft and payload was completed on 19 July 2014. The nominal five-year mission started with four weeks of special, ecliptic-pole scanning and subsequently transferred into full-sky scanning mode. We recall the scientific goals of Gaia and give a description of the as-built spacecraft that is currently (mid-2016) being operated to achieve these goals. We pay special attention to the payload module, the performance of which is closely related to the scientific performance of the mission. We provide a summary of the commissioning activities and findings, followed by a description of the routine operational mode. We summarise scientific performance estimates on the basis of in-orbit operations. Several intermediate Gaia data releases are planned and the data can be retrieved from the Gaia Archive, which is available through the Gaia home page.
|
|
| 10. |
- Sánchez-Cano, Beatriz, et al.
(författare)
-
Solar Energetic Particle Events Detected in the Housekeeping Data of the European Space Agency's Spacecraft Flotilla in the Solar System
- 2023
-
Ingår i: Space Weather. - : American Geophysical Union (AGU). - 1542-7390. ; 21:8
-
Tidskriftsartikel (refereegranskat)abstract
- Despite the growing importance of planetary Space Weather forecasting and radiation protection for science and robotic exploration and the need for accurate Space Weather monitoring and predictions, only a limited number of spacecraft have dedicated instrumentation for this purpose. However, every spacecraft (planetary or astronomical) has hundreds of housekeeping sensors distributed across the spacecraft, some of which can be useful to detect radiation hazards produced by solar particle events. In particular, energetic particles that impact detectors and subsystems on a spacecraft can be identified by certain housekeeping sensors, such as the Error Detection and Correction (EDAC) memory counters, and their effects can be assessed. These counters typically have a sudden large increase in a short time in their error counts that generally match the arrival of energetic particles to the spacecraft. We investigate these engineering datasets for scientific purposes and perform a feasibility study of solar energetic particle event detections using EDAC counters from seven European Space Agency Solar System missions: Venus Express, Mars Express, ExoMars-Trace Gas Orbiter, Rosetta, BepiColombo, Solar Orbiter, and Gaia. Six cases studies, in which the same event was observed by different missions at different locations in the inner Solar System are analyzed. The results of this study show how engineering sensors, for example, EDAC counters, can be used to infer information about the solar particle environment at each spacecraft location. Therefore, we demonstrate the potential of the various EDAC to provide a network of solar particle detections at locations where no scientific observations of this kind are available.
|
|
