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- Macfarlane, M. D., et al.
(författare)
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Shape abnormalities of the caudate nucleus correlate with poorer gait and balance: Results from a subset of the ladis study
- 2015
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Ingår i: The American journal of geriatric psychiatry. - : Elsevier BV. - 1064-7481. ; 23:1, s. 59-U90
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Tidskriftsartikel (refereegranskat)abstract
- Objective Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in frontostriatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter hyperintensities (WMHs) on magnetic resonance imaging has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction. Methods Magnetic resonance imaging scans and clinical gait/balance data (scores from the Short Physical Performance Battery [SPPB]) were sourced from 66 subjects in the previously published LADIS trial, performed in nondisabled individuals older than age 65 years with WMHs at study entry. Data were obtained at study entry and at 3-year follow-up. Caudate nuclei and putamina were manually traced using a previously published method and volumes calculated. The relationships between volume and physical performance on the SPPB were investigated with shape analysis using the spherical harmonic shape description toolkit. Results There was no correlation between the severity of WMHs and striatal volumes. Caudate nuclei volume correlated with performance on the SPPB at baseline but not at follow-up, with subsequent shape analysis showing left caudate changes occurred in areas corresponding to inputs of the dorsolateral prefrontal, premotor, and motor cortex. There was no correlation between putamen volumes and performance on the SPPB. Conclusion Disruption in frontostriatal circuits may play a role in mediating poorer physical performance in individuals with WMHs. Striatal volume and shape changes may be suitable biomarkers for functional changes in this population. © 2015 American Association for Geriatric Psychiatry.
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| 3. |
- Faisal, Shaikh Nayeem, et al.
(författare)
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3D copper-confined N-Doped graphene/carbon nanotubes network as high-performing lithium-ion battery anode
- 2021
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Ingår i: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 850
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Tidskriftsartikel (refereegranskat)abstract
- A facile synthesis of three-dimensional (3D) network of copper confined nitrogen-doped graphene (NG)/carbon nanotube (CNT) with high atomic percentage of nitrogen (10.1 at.%) has been reported. The homogenous intercalation of the CNT network in-between the graphene layers decorated with copper nanoparticles take place which inhibits the self-agglomeration within the lattice and enhance the volumetric storage capability. The composite electrode demonstrates exceptionally high specific capacitance of 1250 mA h/g obtained at a current density of 0.1 A/g which is 3.4 times greater than the theoretical capacity of graphite (372 mA h/g). The discharge-charge profiles (from 0.002 to 3 V) with reversible battery capacity exhibit a stable state of the lithium-ion batteries which were observed at high rate capability of 420 mA h/g at a current density of 1 A/g even after 500 cycles. The enhancement of the electrochemical performance could be attributed to the 3D electrically conductive networks of copper confined nitrogen-doped graphene/carbon nanotubes (Cu@[N-Gr/CNT]).
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