| 1. |
- Gross, Sean M., et al.
(författare)
-
A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses
- 2022
-
Ingår i: Communications Biology. - : Springer Nature. - 2399-3642. ; 5:1
-
Tidskriftsartikel (refereegranskat)abstract
- The phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix proteins. While these signals are normally tightly controlled, their dysregulation leads to phenotypic and molecular states associated with diverse diseases. To develop a detailed understanding of the linkage between molecular and phenotypic changes, we generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB and BMP2. Systematic assessment of the molecular and cellular phenotypes induced by these ligands comprise the LINCS Microenvironment (ME) perturbation dataset, which has been curated and made publicly available for community-wide analysis and development of novel computational methods ( synapse.org/LINCS_MCF10A ). In illustrative analyses, we demonstrate how this dataset can be used to discover functionally related molecular features linked to specific cellular phenotypes. Beyond these analyses, this dataset will serve as a resource for the broader scientific community to mine for biological insights, to compare signals carried across distinct molecular modalities, and to develop new computational methods for integrative data analysis.
|
|
| 2. |
- Filho, W. L., et al.
(författare)
-
Innovation systems and sustainability : An approach for regional clustering and MNCs subsidiaries
- 2012
-
Ingår i: World Review of Science, Technology and Sustainable Development. - 1741-2242 .- 1741-2234. ; 9:1, s. 56-73
-
Forskningsöversikt (refereegranskat)abstract
- Innovation systems significantly contribute to the goals of sustainable development. Observed at the regional level, innovation systems show a tendency that exists in technology intensive production to become spatially concentrated in clusters, allowing the enterprises to have a higher degree of specialisation, collective efficiency and competitive advantage. This paper aims to analyse knowledge interactions for sustainability-oriented regional innovation systems. It is empirically examined in the context of the regional innovation system of Campinas, which represents Brazil's leading telecom agglomeration, fostered by governmental policies, endogenous efforts by the region's scientific institutions, equally by extra sources such as the setup of subsidiaries of multinational corporations (MNCs). The results from this study may assist in both innovation systems research and sustainability policy making, especially in emerging economies.
|
|
| 3. |
- Santos, Rita, et al.
(författare)
-
Technological trajectories and sustainability : An intersector analysis of Brazilian subsidiaries of Swedish multinational corporations
- 2012
-
Ingår i: Handbook of Sustainability Management. - : World Scientific Pub Co Pte Ltd. ; , s. 765-782
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Evolutionary theories on technological change are particularly useful for understanding technological regime shifts toward the environment and its sustainability. It is argued that fundamental changes in production processes and consumption patterns underpinned by alternative technological trajectories are required for achieving environmental sustainable direction. Such changes, which go beyond the control of particular pollutants and eco-efficiency improvements, are referred to as technological regime shifts. The focuses of this chapter is to review the relationship between technological trajectories to the issue of environmental technological change. This is illustrated by certain selected sectors of Brazilian subsidiaries of Swedish multinational corporations (MNCs). Technological trajectories are expressed through process innovations: (i) a sequence of steps on incremental innovation; (ii) a sequence of steps oriented toward radical innovation, associated with products to redefine the market, exposing structural change. The chapter seeks to enlarge the understanding of the intricate process of sustainability and technological paths of the subsidiaries of MNCs in newly industrialized countries.
|
|
| 4. |
- von Mackensen, S., et al.
(författare)
-
Development of a disease-specific quality of life questionnaire for children & adolescents with idiopathic thrombocytopenic purpura (ITP-QoL)
- 2006
-
Ingår i: Pediatric Blood & Cancer. - : Wiley. - 1545-5017 .- 1545-5009. ; 47:Suppl.5, s. 688-691
-
Tidskriftsartikel (refereegranskat)abstract
- Quality of life (QoL) assessment in children with coagulation disorders is a relatively unstudied area. While hemophilia-specific questionnaires (such as Haemo-QoL) are available, no instrument for children with idiopathic thrombocytopenic purpura (ITP) has been validated yet. A disease-specific questionnaire for children with ITP was therefore developed (ITP-QoL) in three phases: (a) a preparatory phase; (b) a developmental phase; (c) a pilot testing phase. Since dimensions of Haemo-QoL were considered important for children with ITP, items were adapted, reformulated and additional dimensions were included. Two age-group versions were designed for children (aged 3-7, 8-18 years) and parents in Italian, German, and Swedish languages and were pilot tested. Pediatr Blood Cancer 2006;47:688-691. (c) 2006 Wiley-Liss, Inc.
|
|
