| 1. |
- Mogi, Kazumasa, et al.
(författare)
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9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins
- 2023
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Ingår i: Scientific Reports. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Mucosal human papillomavirus (HPV) subtypes 16 and 18 are causative agents of cervical cancer, a leading cause of cancer-related deaths among women worldwide. In Japan, eggplant calyx is a folk remedy used to treat common warts. 9-oxo-(10E,12E)-octadecadienoic acid, isolated from eggplant calyx, may have antitumor effects. This study investigated the antitumor effects of 9-oxo-(10E, 12Z)-octadecadienoic acid and 9-oxo-(10E,12E)-octadecadienoic acid (9-oxo-ODAs) on human cervical cancer cells. 9-oxo-ODAs suppressed the proliferation of human cervical cancer cell lines (HeLa, and SiHa) in a concentration-dependent manner (IC50 = 25–50 µM). FCM analysis revealed that 9-oxo-ODAs induced apoptosis. Transcriptome, proteomics, and enrichment analyses revealed that treatment with 9-oxo-ODAs significantly altered the cell cycle and p53 pathways and decreased cyclin-dependent kinase 1 (CDK1) protein expression. Real-time PCR analysis demonstrated that 9-oxo-ODAs reduced CDK1 mRNA expression in a concentration-dependent manner. In vitro, 9-oxo-ODAs reduced the HPV oncoprotein expression. In ex vivo human cervical cancer tissues, 9-oxo-ODAs decreased CDK1 expression and increased cleaved caspase 3, an apoptosis marker. Further, 9-oxo-ODAs showed the potential to suppressed metastatic formation and growth of cervical cancer in vivo. These findings suggest that 9-oxo-ODAs induce cell cycle arrest and apoptosis in HPV-positive human cervical cancer cells, and this process involves CDK1. Consequently, 9-oxo-ODAs may be potential therapeutic agents for cervical cancer.
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| 2. |
- Morokuma, Tomoki, et al.
(författare)
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OISTER optical and near-infrared monitoring observations of peculiar radio-loud active galactic nucleus SDSSJ110006.07+442144.3
- 2017
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Ingår i: Nippon Tenmon Gakkai obun kenkyu hokoku. - : Oxford University Press (OUP). - 0004-6264. ; 69:5
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Tidskriftsartikel (refereegranskat)abstract
- We present monitoring campaign observations at optical and near-infrared (NIR) wavelengths for a radio-loud active galactic nucleus (AGN) at z = 0.840, SDSSJ110006.07+442144.3 (hereafter, J1100+4421), which was identified during a flare phase in late 2014 February. The campaigns consist of three intensive observing runs from the discovery to 2015 March, mostly within the scheme of the OISTER collaboration. Optical-NIR light curves and simultaneous spectral energy distributions (SEDs) are obtained. Our measurements show the strongest brightening in 2015 March. We found that the optical-NIR SEDs of J1100+4421 show an almost steady shape despite the large and rapid intranight variability. This constant SED shape is confirmed to extend to similar to 5 mu m in the observed frame using the archival WISE data. Given the lack of absorption lines and the steep power-law spectrum of alpha(upsilon) similar to -1.4, where f(v) proportional to v(alpha upsilon), synchrotron radiation by a relativistic jet with no or small contributions from the host galaxy and the accretion disk seemsmost plausible as an optical-NIR emission mechanism. The steep optical-NIR spectral shape and the large amplitude of variability are consistent with this object being a low.peak jet-dominated AGN. In addition, sub-arcsecond resolution optical imaging data taken with Subaru Hyper Suprime-Cam does not show a clear extended component and the spatial scales are significantly smaller than the large extensions detected at radio wavelengths. The optical spectrum of a possible faint companion galaxy does not show any emission lines at the same redshift, and hence a merging hypothesis for this AGN-related activity is not supported by our observations.
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| 3. |
- Salak, Dragan, et al.
(författare)
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Molecular Outflow in the Reionization-epoch Quasar J2054-0005 Revealed by OH 119 μ m Observations
- 2024
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 962:1
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Tidskriftsartikel (refereegranskat)abstract
- Molecular outflows are expected to play a key role in galaxy evolution at high redshift. To study the impact of outflows on star formation at the epoch of reionization, we performed sensitive Atacama Large Millimeter/submillimeter Array observations of OH 119 mu m toward J2054-0005, a luminous quasar at z = 6.04. The OH line is detected and exhibits a P-Cygni profile that can be fitted with a broad blueshifted absorption component, providing unambiguous evidence of an outflow, and an emission component at near-systemic velocity. The mean and terminal outflow velocities are estimated to be v(out )approximate to 670 and 1500 km s(-1), respectively, making the molecular outflow in this quasar one of the fastest at the epoch of reionization. The OH line is marginally spatially resolved for the first time in a quasar at z > 6, revealing that the outflow extends over the central 2 kpc region. The mass outflow rate is comparable to the star formation rate (M-out/SFR similar to 2), indicating rapid (similar to 10(7 )yr) quenching of star formation. The mass outflow rate in a sample of star-forming galaxies and quasars at 4 < z < 6.4 exhibits a positive correlation with the total infrared luminosity, although the scatter is large. Owing to the high outflow velocity, a large fraction (up to similar to 50%) of the outflowing molecular gas may be able to escape from the host galaxy into the intergalactic medium.
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| 4. |
- Wang, Hongjing, et al.
(författare)
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Synthesis of Mesoporous Pt Films with Tunable Pore Sizes from Aqueous Surfactant Solutions
- 2012
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Ingår i: Chemistry of Materials. - : American Chemical Society (ACS). - 0897-4756 .- 1520-5002. ; 24:9, s. 1591-1598
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Tidskriftsartikel (refereegranskat)abstract
- Platinum (Pt) is widely used as battery electrodes, catalysts for chemicals, and catalysts for exhaust gas decomposition in industries. Increasing need and very limited supply of rare Pt is a serious problem in the world. Here, we propose new synthetic way for reducing the use of Pt in a catalytic system by increasing the surface area and modifying the Pt surface structure. Several types of mesoporous Pt films with different pore sizes ranging from 5 to 30 nm are prepared by electrochemical plating in aqueous surfactant solutions. The mesopore walls are composed of connected Pt nanoparticles with around 3 nm in diameter. The Pt atomic crystallinity is coherently extending across over several Pt nanoparticles, showing a large number of atomic steps, which can accelerate methanol oxidation reaction. As a result of a high surface area and unique Pt surface, our mesoporous Pt film exhibits high potentiality as a superior electrocatalyst.
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