| 1. |
- Horger, B A, et al.
(författare)
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Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons
- 1998
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Ingår i: The Journal of Neuroscience. - 1529-2401. ; 18:13, s. 4929-4937
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Tidskriftsartikel (refereegranskat)abstract
- Glial cell line-derived neurotrophic factor (GDNF) exhibits potent effects on survival and function of midbrain dopaminergic (DA) neurons in a variety of models. Although other growth factors expressed in the vicinity of developing DA neurons have been reported to support survival of DA neurons in vitro, to date none of these factors duplicate the potent and selective actions of GDNF in vivo. We report here that neurturin (NTN), a homolog of GDNF, is expressed in the nigrostriatal system, and that NTN exerts potent effects on survival and function of midbrain DA neurons. Our findings indicate that NTN mRNA is sequentially expressed in the ventral midbrain and striatum during development and that NTN exhibits survival-promoting actions on both developing and mature DA neurons. In vitro, NTN supports survival of embryonic DA neurons, and in vivo, direct injection of NTN into the substantia nigra protects mature DA neurons from cell death induced by 6-OHDA. Furthermore, administration of NTN into the striatum of intact adult animals induces behavioral and biochemical changes associated with functional upregulation of nigral DA neurons. The similarity in potency and efficacy of NTN and GDNF on DA neurons in several paradigms stands in contrast to the differential distribution of the receptor components GDNF Family Receptor alpha1 (GFRalpha1) and GFRalpha2 within the ventral mesencephalon. These results suggest that NTN is an endogenous trophic factor for midbrain DA neurons and point to the possibility that GDNF and NTN may exert redundant trophic influences on nigral DA neurons acting via a receptor complex that includes GFRalpha1.
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| 2. |
- Ravanfar, P, et al.
(författare)
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In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia
- 2022
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Ingår i: Schizophrenia (Heidelberg, Germany). - : Springer Science and Business Media LLC. - 2754-6993. ; 8:1, s. 86-
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Tidskriftsartikel (refereegranskat)abstract
- Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in schizophrenia. The role of brain iron in schizophrenia and its potential link to oxidative stress has not been previously examined. In this study, we used 7-Tesla MRI quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and structural T1 imaging in 12 individuals with chronic schizophrenia and 14 healthy age-matched controls. In schizophrenia, there were higher QSM values in bilateral putamen and higher concentrations of phosphocreatine and lactate in caudal anterior cingulate cortex (caCC). Network-based correlation analysis of QSM across corticostriatal pathways as well as the correlation between QSM, MRS, and volume, showed distinct patterns between groups. This study introduces increased iron in the putamen in schizophrenia in addition to network-wide disturbances of iron and metabolic status.
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| 3. |
- Rosenblad, C, et al.
(författare)
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Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
- 1999
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Ingår i: European Journal of Neuroscience. - 1460-9568. ; 11:5, s. 1554-1566
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Tidskriftsartikel (refereegranskat)abstract
- Both glial cell line-derived neurotrophic factor (GDNF) and its recently discovered congener, neurturin (NTN), have been shown to exert neuroprotective effects on lesioned nigral dopamine (DA) neurons when administered at the level of the substantia nigra. In the present study, we have explored the relative in vivo potency of these two neurotrophic factors using two alternative routes of administration, into the striatum or the lateral ventricle, which may be more relevant in a clinical setting. In rats subjected to an intrastriatal (IS) 6-hydroxydopamine (6-OHDA) lesion, GDNF and NTN were injected every third day for 3 weeks starting on the day after the 6-OHDA injection. GDNF provided almost complete (90-92%) protection of the lesioned nigral DA neurons after both IS and intracerebroventricular (ICV) administration. NTN, by contrast, was only partially effective after IS injection (72% sparing) and totally ineffective after ICV injection. Although the trophic factor injections protected the nigral neurons from lesion-induced cell death, the level of expression of the phenotypic marker, tyrosine hydroxylase (TH), was markedly reduced in the rescued cell bodies. The extent of 6-OHDA-induced DA denervation in the striatum was unaffected by both types of treatment; consistent with this observation, the high rate of amphetamine-induced turning seen in the lesioned control animals was unaltered by either GDNF or NTN treatment. In the GDNF-treated animals, and to a lesser extent also after IS NTN treatment, prominent axonal sprouting was observed within the globus pallidus, at the level where the lesioned nigrostriatal axons are known to end at the time of onset of the neurotrophic factor treatment. The results show that GDNF is highly effective as a neuroprotective and axon growth-stimulating agent in the IS 6-OHDA lesion model after both IS and ICV administration. The lower efficacy of NTN after IS, and particularly ICV, administration may be explained by the poor solubility and diffusion properties at neutral pH.
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| 4. |
- Wade, G. A., et al.
(författare)
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The MiMeS survey of magnetism in massive stars : introduction and overview
- 2016
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 456:1, s. 2-22
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The MiMeS (Magnetism in Massive Stars) project is a large-scale, high-resolution, sensitive spectropolarimetric investigation of the magnetic properties of O- and early B-type stars. Initiated in 2008 and completed in 2013, the project was supported by three Large Program allocations, as well as various programmes initiated by independent principal investigators, and archival resources. Ultimately, over 4800 circularly polarized spectra of 560 O and B stars were collected with the instruments ESPaDOnS (Echelle SpectroPolarimetric Device for the Observation of Stars) at the Canada-France-Hawaii Telescope, Narval at the Telescope Bernard Lyot and HARPSpol at the European Southern Observatory La Silla 3.6 m telescope, making MiMeS by far the largest systematic investigation of massive star magnetism ever undertaken. In this paper, the first in a series reporting the general results of the survey, we introduce the scientific motivation and goals, describe the sample of targets, review the instrumentation and observational techniques used, explain the exposure time calculation designed to provide sensitivity to surface dipole fields above approximately 100 G, discuss the polarimetric performance, stability and uncertainty of the instrumentation, and summarize the previous and forthcoming publications.
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| 5. |
- Weigelt, G., et al.
(författare)
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VLTI-MATISSE chromatic aperture-synthesis imaging of eta Carinae's stellar wind across the Br alpha line Periastron passage observations in February 2020
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 652
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Tidskriftsartikel (refereegranskat)abstract
- Context. Eta Carinae is a highly eccentric, massive binary system (semimajor axis similar to 15.5 au) with powerful stellar winds and a phase-dependent wind-wind collision (WWC) zone. The primary star, eta Car A, is a luminous blue variable (LBV); the secondary, eta Car B, is a Wolf-Rayet or O star with a faster but less dense wind. Aperture-synthesis imaging allows us to study the mass loss from the enigmatic LBV eta Car. Understanding LBVs is a crucial step toward improving our knowledge about massive stars and their evolution. Aims. Our aim is to study the intensity distribution and kinematics of eta Car's WWC zone. Methods. Using the VLTI-MATISSE mid-infrared interferometry instrument, we perform Br alpha imaging of eta Car's distorted wind. Results. We present the first VLTI-MATISSE aperture-synthesis images of eta Car A's stellar windin several spectral channels distributed across the Br alpha 4.052 mu m line (spectral resolving power R similar to 960). Our observations were performed close to periastron passage in February 2020 (orbital phase similar to 14.0022). The reconstructed iso-velocity images show the dependence of the primary stellar wind on wavelength or line-of-sight (LOS) velocity with a spatial resolution of 6 mas (similar to 14 au). The radius of the faintest outer wind regions is similar to 26 mas (similar to 60 au). At several negative LOS velocities, the primary stellar wind is less extended to the northwest than in other directions. This asymmetry is most likely caused by the WWC. Therefore, we see both the velocity field of the undisturbed primary wind and the WWC cavity. In continuum spectral channels, the primary star wind is more compact than in line channels. A fit of the observed continuum visibilities with the visibilities of a stellar wind CMFGEN model (CMFGEN is an atmosphere code developed to model the spectra of a variety of objects) provides a full width at half maximum fit diameter of the primary stellar wind of 2.84 +/- 0.06 mas (6.54 +/- 0.14 au). We comparethe derived intensity distributions with the CMFGEN stellar wind model and hydrodynamic WWC models.
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| 8. |
- Gaffney, K J, et al.
(författare)
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Observation of structural anisotropy and the onset of liquidlike motion during the nonthermal melting of InSb
- 2005
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 95:12
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Tidskriftsartikel (refereegranskat)abstract
- The melting dynamics of laser excited InSb have been studied with femtosecond x-ray diffraction. These measurements observe the delayed onset of diffusive atomic motion, signaling the appearance of liquidlike dynamics. They also demonstrate that the root-mean-squared displacement in the [111] direction increases faster than in the [110] direction after the first 500 fs. This structural anisotropy indicates that the initially generated fluid differs significantly from the equilibrium liquid.
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| 9. |
- Hareter, M., et al.
(författare)
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MOST discovers a multimode delta Scuti star in a triple system : HD 61199
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 492:1, s. 185-195
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Tidskriftsartikel (refereegranskat)abstract
- Context. A field star, HD61199 (V approximate to 8), simultaneously observed with Procyon by the MOST (Microvariability & Oscillations of STars) satellite in continuous runs of 34, 17, and 34 days in 2004, 2005, and 2007, was found to pulsate in 11 frequencies in the delta Scuti range with amplitudes from 1.7 down to 0.09 mmag. The photometry also showed variations with a period of about four days. To investigate the nature of the longer period, 45 days of time-resolved spectroscopy was obtained at the Thuringer Landessternwarte Tautenburg in 2004. The radial velocity measurements indicate that HD61199 is a triple system. Aims. A delta Scuti pulsator with a rich eigenspectrum in a multiple system is promising for asteroseismology. Our objectives were to identify which of the stars in the system is the delta Scuti variable and to obtain the orbital elements of the system and the fundamental parameters of the individual components, which are constrained by the pulsation frequencies of the delta Scuti star.Methods. Classical Fourier techniques and least-squares multi-sinusoidal fits were applied to the MOST photometry to identify the pulsation frequencies. The groundbased spectroscopy was analysed with least-squares-deconvolution (LSD) techniques, and the orbital elements derived with the KOREL and ORBITX routines. Asteroseismic models were also generated. Results. The photometric and spectroscopic data are compatible with a triple system consisting of a close binary with an orbital period of 3.57 days and a d Scuti companion (HD61199 A) as the most luminous component. The d Scuti star is a rapid rotator with about v sin i = 130 km s(-1) and an upper mass limit of about 2.1 M-circle dot. For the close binary components, we find they are of nearly equal mass, with lower mass limits of about 0.7 M-circle dot. Comparisons to synthetic spectra indicate these stars have a late-F spectral type. The observed oscillation frequencies are compared to pulsation models to further constrain the evolutionary state and mass of HD61199 A. The orbit frequency of the close binary corresponds to the difference of the two d Scuti frequencies with the highest amplitudes a coincidence that is remarkable, but not explained.
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| 10. |
- Knudsen, D. J., et al.
(författare)
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Thermal ion imagers and Langmuir probes in the Swarm electric field instruments
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 122:2, s. 2655-2673
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Tidskriftsartikel (refereegranskat)abstract
- The European Space Agency's three Swarm satellites were launched on 22 November 2013 into nearly polar, circular orbits, eventually reaching altitudes of 460 km (Swarm A and C) and 510 km (Swarm B). Swarm's multiyear mission is to make precision, multipoint measurements of low-frequency magnetic and electric fields in Earth's ionosphere for the purpose of characterizing magnetic fields generated both inside and external to the Earth, along with the electric fields and other plasma parameters associated with electric current systems in the ionosphere and magnetosphere. Electric fields perpendicular to the magnetic field.B are determined through ion drift velocity v(i) and magnetic field measurements via the relation.E. = -.vi x.B. Ion drift is derived from two-dimensional images of low-energy ion distribution functions provided by two Thermal Ion Imager (TII) sensors viewing in the horizontal and vertical planes;v(i) is corrected for spacecraft potential as determined by two Langmuir probes (LPs) which also measure plasma density ne and electron temperature T-e. The TII sensors use a microchannel-plate-intensified phosphor screen imaged by a charge-coupled device to generate high-resolution distribution images (66 x 40 pixels) at a rate of 16 s(-1). Images are partially processed on board and further on the ground to generate calibrated data products at a rate of 2 s(-1); these include.vi,.E., and ion temperature T-i in addition to electron temperature Te and plasma density n(e) from the LPs.
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