| 1. |
- Qin, Jian, et al.
(författare)
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A high-performance magnetic resonance imaging T2 contrast agent
- 2007
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 19:14, s. 1874-1878
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Tidskriftsartikel (refereegranskat)abstract
- A high-performance magnetic resonance imaging T-2 contrast agent has been prepared via phase transfer of hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) to an aqueous solution by using Pluronic F127 copolymers. As seen in the figure, a hierarchical structure of the surface coating is formed and proven to be a crucial characteristic to enhance not only water dispersibility, but also the efficacy as a T-2 contrast agent.
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| 2. |
- Reinthaler, Eva M., et al.
(författare)
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TPP2 mutation associated with sterile brain inflammation mimicking MS
- 2018
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Ingår i: NEUROLOGY-GENETICS. - 2376-7839. ; 4:6
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Tidskriftsartikel (refereegranskat)abstract
- Objective To ascertain the genetic cause of a consanguineous family from Syria suffering from a sterile brain inflammation mimicking a mild nonprogressive form of MS.Methods We used homozygosity mapping and next-generation sequencing to detect the disease-causing gene in the affected siblings. In addition, we performed RNA and protein expression studies, enzymatic activity assays, immunohistochemistry, and targeted sequencing of further MS cases from Austria, Germany, Canada and Jordan.Results In this study, we describe the identification of a homozygous missense mutation (c.82T>G, p.Cys28Gly) in the tripeptidyl peptidase II (TPP2) gene in all 3 affected siblings of the family. Sequencing of all TPP2-coding exons in 826 MS cases identified one further homozygous missense variant (c.2027C>T, p.Thr676Ile) in a Jordanian MS patient. TPP2 protein expression in whole blood was reduced in the affected siblings. In contrast, TPP2 protein expression in postmortem brain tissue from MS patients without TPP2 mutations was highly upregulated.Conclusions The homozygous TPP2 mutation (p.Cys28Gly) is likely responsible for the inflammation phenotype in this family. TPP2 is an ubiquitously expressed serine peptidase that removes tripeptides from the N-terminal end of longer peptides. TPP2 is involved in various biological processes including the destruction of major histocompatibility complex Class I epitopes. Recessive loss-of-function mutations in TPP2 were described in patients with Evans syndrome, a rare autoimmune disease affecting the hematopoietic system. Based on the gene expression results in our MS autopsy brain samples, we further suggest that TPP2 may play a broader role in the inflammatory process in MS.
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| 3. |
- Salih, Sami, et al.
(författare)
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A novel spectrum sensing scheduler algorithm for Cognitive Radio Networks
- 2013
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Konferensbidrag (refereegranskat)abstract
- Cognitive Radios' is recognized as a novel approach to improve the utilization of a precious wireless communication natural resource; the radio frequency spectrum. Historically, telecom regulators assigned fixed spectrum bands to the licensee wireless network operators, this spectrum management approach is guarantee interference free environment, except of some configurations faults or illegal usage. However, with the increasing demand for more bandwidth in the finite radio spectrum, the concept of secondary operator's was emerged, but with emphases to not influence licensed operators. Consequently, Cognitive Radio Networks (CRN) architecture enters the market as an intelligent solution to these issues, with concentration on the spectrum sensing procedures to achieve the regulatory constraint. The most successful sensing algorithms is those applying cooperation and scheduling to have better scanning information, however those algorithms are developed base on the primary network activities which is good in terms of reducing the expected interference, but it lay more computational loads on the CRN. In this paper, a novel sensing scheduler algorithm is proposed, the idea is to utilize the CRN by fairly distribute the sensing task among the sensors, then utilizing the radio spectrum shared with the primary networks.
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| 4. |
- Salih, Sami, et al.
(författare)
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Implementation of adaptive modulation for broadband wireless access networks using cognitive radio approaches
- 2013
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Konferensbidrag (refereegranskat)abstract
- Broadband Wireless Access (BWA) has become the best way to meet escalating business demand for rapid Internet connection and integrated 'triple play' services. In addition, not only for topographic but also for technological limitations, alternative wireless solutions have been found. These systems are designed based on Cognitive Radio (CR) approaches, which can adjust its operation according to the environment and technical variations. This tracking feature allows the communication system to deliver the Best Ever, compare to Best Effort, services to the users. In this paper, an implementation of a cognitive engine for adaptive modulation and coding (AMC) is presented. This engine will track the radio channel variations in terms of SNR and be able to select a suitable modulation order among predefined Modulation and Coding Schemes (MCS) to maintain the specified BER by the user requirements.
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