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- Do, Ron, et al.
(författare)
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Common variants associated with plasma triglycerides and risk for coronary artery disease
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1345-
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Tidskriftsartikel (refereegranskat)abstract
- Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
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| 4. |
- Moilanen, Sanna, et al.
(författare)
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Do parenthood worries impede the birth of a second child? Differences according to the parent's gender and spousal support in Finland
- 2024
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Ingår i: JFR journal of family research. - 2699-2337. ; 36, s. 103-125
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study examines the extent to which the experience of parenthood worries among Finnish firsttime parents predicts the probability of a second birth, and whether the associations differ according to the parent's gender or the sufficiency of spousal support in parenting. Background: First-time parents' withdrawal from having a second child has been connected to declining fertility rates in Finland and many other high -income countries; consequently, more understanding is needed about why parents potentially refrain from subsequent childbearing. Method: We utilize longitudinal survey data collected from Finnish parents ( N = 544) in three waves (2016- 2020). Results: The results show that experiencing parenthood worries significantly predicts the probability of a second birth. Specifically, the accumulation of parenthood worries predicted a lower probability of a second birth, and each additional worry decreased the probability significantly more for fathers compared to mothers. Although we found no gender differences regarding the associations between specific parenthood worries and the probability of a second birth, our results showed that fathers who worried about loneliness or having sole responsibility for parenting were less likely to have a second child than fathers with no such worries. In terms of the sufficiency of spousal support in parenting, we found, first, that among parents who received insufficient spousal support, those who worried about their parenting skills adequacy had a lower probability of a second birth than those with no such worries. Second, among parents with sufficient spousal support, worrying about their own ability to cope was associated with decreased probability of a second birth compared to those who did not experience such worry. Conclusion: Our findings provide new insights into the potential influence of parenthood worries experienced by first-time parents and the role of spousal support in subsequent childbearing.
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| 5. |
- Willer, Cristen J., et al.
(författare)
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Discovery and refinement of loci associated with lipid levels
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1274-1283
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Tidskriftsartikel (refereegranskat)abstract
- Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
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