| 1. |
- Molin, Karl, 1944-, et al.
(författare)
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Historieatlasen
- 2010. - 1
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Bok (populärvet., debatt m.m.)
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| 2. |
- Andersson, Kristina E, et al.
(författare)
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Diverse effects of oats on cholesterol metabolism in C57BL/6 mice correlate with expression of hepatic bile acid-producing enzymes.
- 2013
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Ingår i: European Journal of Nutrition. - : Springer Science and Business Media LLC. - 1436-6215 .- 1436-6207. ; 52:7, s. 1755-1769
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: We previously reported that two substrains of C57BL/6 mice respond differently to oats with respect to reduction in plasma cholesterol. Analysis of this difference might offer clues to mechanisms behind the cholesterol-lowering effect of oats. Here, we address the possible roles of hepatic steroid metabolism and the intestinal microbiota in this respect. METHODS: Female C57BL/6 mice were fed an atherogenic diet with oat bran (27 %) or control fibres for 4 weeks. RESULTS: C57BL/6 NCrl mice responded to oat bran with 19 ± 1 % (P < 0.001) lower plasma cholesterol, 40 ± 5 % (P < 0.01) higher excretion of bile acids and increased expression of the bile acid-producing hepatic enzymes CYP7A1 and CYP8B1, but none of these effects were found in C57BL/6JBomTac mice. However, on control diet, C57BL/6JBomTac had tenfold higher expression of CYP7A1 and levels of hepatic cholesterol esters than C57BL/6NCrl mice. Plasma levels of fructosamine indicated improved glycemic control by oat bran in C57BL/6NCrl but not in C57BL/6JBomTac. C57BL/6JBomTac had higher intestinal microbiota diversity, but lower numbers of Enterobacteriaceae, Akkermansia and Bacteroides Fragilis than C57BL/6NCrl mice. Oat bran increased bacterial numbers in both substrains. Microbiota diversity was reduced by oats in C57BL/6JBomTac, but unaffected in C57BL/6NCrl. CONCLUSIONS: Our data do not support a connection between altered microbiota diversity and reduced plasma cholesterol, but the bacterial composition in the intestine may influence the effects of added fibres. The cholesterol-lowering properties of oats involve increased production of bile acids via the classical pathway with up-regulation of CYP7A1 and CYP8B1. Altered cholesterol or bile acid metabolism may interfere with the potential of oats to reduce plasma cholesterol.
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| 3. |
- Barré, Benjamin P., et al.
(författare)
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Intragenic repeat expansion in the cell wall protein gene HPF1 controls yeast chronological aging
- 2020
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Ingår i: Genome Research. - : Cold Spring Harbor Laboratory. - 1088-9051 .- 1549-5469. ; 30:5, s. 697-710
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Tidskriftsartikel (refereegranskat)abstract
- Aging varies among individuals due to both genetics and environment, but the underlying molecular mechanisms remain largely unknown. Using a highly recombined Saccharomyces cerevisiae population, we found 30 distinct quantitative trait loci (QTLs) that control chronological life span (CLS) in calorie-rich and calorie-restricted environments and under rapamycin exposure. Calorie restriction and rapamycin extended life span in virtually all genotypes but through different genetic variants. We tracked the two major QTLs to the cell wall glycoprotein genes FLO11 and HPF1. We found that massive expansion of intragenic tandem repeats within the N-terminal domain of HPF1 was sufficient to cause pronounced life span shortening. Life span impairment by HPF1 was buffered by rapamycin but not by calorie restriction. The HPF1 repeat expansion shifted yeast cells from a sedentary to a buoyant state, thereby increasing their exposure to surrounding oxygen. The higher oxygenation altered methionine, lipid, and purine metabolism, and inhibited quiescence, which explains the life span shortening. We conclude that fast-evolving intragenic repeat expansions can fundamentally change the relationship between cells and their environment with profound effects on cellular lifestyle and longevity.
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| 4. |
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| 5. |
- Eliasson, Ulf, 1965-
(författare)
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Övervakning i försvarets intresse : Säkerhetspolisens övervakning och registrering av ytterlighetspartier 1917-1945
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is focusing on two key questions. 1. Why and to what extent did the Swedish security service monitor and register sympathizers of the extremist political parties at the end of World War I and in the subsequent inter-war period? 2. To what extent did the Swedish government - by means of inspection, observation and management - control the surveillance and registration of the extremist political parties by the security service in 1917-1945? The study compares the development in Sweden with a trajectory of development that is formulated in the literature from observations mainly in Canada and Australia. The characteristics of this trajectory are that security agencies in the 20thcentury were autonomous in their relation with the government and expansionist in terms of their surveillance activities. This dissertation comes to two key conclusions. The first is that the surveillance and registration of Communists during the inter-war period intensified in 1930 when the military’s perception of the communist threat shifted. In 1928 the Communist movement formulated a new tactic of infiltrating the armed forces; in consequence the military introduced loyalty tests of its personnel (security vetting). The second conclusion is that the military’s and, in the winter of 1939, the government’s expansionist view of the need for surveillance and registration of the extremist political parties stands in sharp contrast to the restrictive view on this issue that was formulated by the security service. Partly as a result of this attitude of the security service, the Minister of Justice and the Minister of Social Affairs controlled the Swedish security service during World War II. I argue that the Swedish security service was restrictive rather than expansionist in its view of the surveillance and registration of the political extremist parties in 1917-1945. I also make the case that its relationship with the government on issues related to these activities was characterized by control rather than by autonomy.
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| 6. |
- Erlandsson, Susanna, 1970-
(författare)
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Window of opportunity : Dutch and Swedish security ideas and strategies 1942–1948
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The period treated in this thesis is one which is often characterized as a transition between World War II and the Cold War. By approaching it instead as a window of opportunity – a period in which the governments of small states perceived both an unusual space and an urgent need to reevaluate security – the security policies of two small northwestern European countries, the Netherlands and Sweden, are subjected to a critical reappraisal. Through a systematic comparison of the security ideas and strategies in two countries that ended up with different positions on alignment/non-alignment during the Cold War, this dissertation sheds new light on the reasons for the development of those security policies as well as on their significance. Not only does it uncover a number of concrete security strategies that were remarkably similar regardless of different circumstances, but it shows that the Swedish and Dutch governments formed similar ideas about the needs for future security in spite of different war experiences. Both concluded that small states could no longer survive in isolation and instead aimed for a better functioning system of collective security, built on the close cooperation of regional groups. This thesis argues that the different choices regarding security in 1948, when the Dutch signed the Treaty of Brussels and the Swedish reclaimed a policy of non-alignment, were in fact motivated by the same wish to maintain as wide a margin for manoeuvre as possible for the cooperation envisioned during the war, seeing this as the best guarantee of peace and independence.
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| 7. |
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| 8. |
- Fällström, Karl-Evert, et al.
(författare)
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Mechanical and thermal effects in a steel plate impacted by a focused laser pulse
- 1997
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Ingår i: Nondestructive Testing and Evaluation. - : Informa UK Limited. - 1058-9759 .- 1477-2671. ; 13:5, s. 293-307
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Tidskriftsartikel (refereegranskat)abstract
- A short laser pulse from a 1 J ruby laser is focused at a steel plate. The effect will be that the material surface at the impact point becomes very rapidly heated. Metal vapour leaves the surface at a very high velocity. That is, both a mechanical impulse and local thermal energy are transferred to the plate. The mechanical impulse creates propagating bending waves in the plate, which in turn creates transient sound waves in the surrounding air. The heated spot at the plate surface creates thermal stresses in the plate which give rise to an out-of-plane deformation of the plate. This deformation is added up to the propagating bending waves. These effects are studied in experiments using pulsed holographic interferometry.
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| 9. |
- Fällström, Karl-Evert, et al.
(författare)
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Nondestructive method to determine material properties in orthotropic plates
- 1987
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Ingår i: Polymer Composites. - : Wiley. - 0272-8397 .- 1548-0569. ; 8:2, s. 103-108
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Tidskriftsartikel (refereegranskat)abstract
- An electronic speckle pattern interferometer (ESPI) is used to determine modes of vibration in rectangular, orthotropic, free-free-plates; that is using a noncontact, nondestructive, optical method. It is shown, using the finite element method (FEM), that each of the first three modes of vibration in rectangular orthotropic plates has a strong dependence upon only one of the main material parameters, namely the in-plane shear modulus and the two Young's moduli, respectively. With this one-variable dependence it is a simple task to determine the effective material parameters. This method has several obvious advantages compared to the use of test bars and it can be extended to give a measure of the damping parameters and probably also be used for production control. Preliminary results are presented and discussed
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| 10. |
- Fällström, Karl-Evert, et al.
(författare)
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Transient bending waves in anisotropic plates studied by hologram interferometry
- 1989
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Ingår i: Experimental mechanics. - 0014-4851 .- 1741-2765. ; 29:4, s. 409-413
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Tidskriftsartikel (refereegranskat)abstract
- Propagating bending waves are studied in plates made of glass-fiber reinforced polyester. The waves are generated by the impact of a ballistic pendulum. Hologram interferometry, with a double pulsed ruby laser as light source, is used to record the out of plane motion of the waves. The interferograms have an elliptic-like symmetry for an orthotropic plate, while the wave pattern for a symmetric angle-ply reinforced plate has a symmetry about the axes of reinforcements. Experimental data are compared on one hand to analytical results obtained by assuming that the orthotropic plate can be described as if isotropic along the main axes, and on the other hand to numerical results from calculations using the finite-element method. The effective Young's modulus raised to power 1/4 is shown to be an important parameter for the description of the dispersive wave pattern. A defect in the plate alters the wave pattern in the interferograms significantly. This may have technical use.
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