| 1. |
- Jensen, Simon S., et al.
(författare)
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Group 1 ITI Consensus Report : The role of bone dimensions and soft tissue augmentation procedures on the stability of clinical, radiographic, and patient-reported outcomes of implant treatment
- 2023
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Ingår i: Clinical Oral Implants Research. - : John Wiley & Sons. - 0905-7161 .- 1600-0501. ; 34, s. 43-49
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aims of Working Group 1 were to address the role (i) of the buccolingual bone dimensions after implant placement in healed alveolar ridge sites on the occurrence of biologic and aesthetic complications, and (ii) of soft tissue augmentation (STA) on the stability of clinical, radiographic, and patient-related outcomes of implant treatments.Materials and Methods: Two systematic reviews were prepared in advance of the Consensus Conference and were discussed among the participants of Group 1. Consensus statements, clinical recommendations, recommendations for future research, and reflections on patient perspectives were based on structured group discussions until consensus was reached among the entire group of experts. The statements were then presented and accepted following further discussion and modifications as required by the plenary.Results: Dimensional changes of the alveolar ridge occurred after implant placement in healed sites, and a reduction in buccal bone wall thickness (BBW) of 0.3 to 1.8 mm was observed. In healed sites with a BBW of <1.5 mm after implant placement, increased vertical bone loss, and less favorable clinical and radiographic outcomes were demonstrated. Implants with buccal dehiscence defects undergoing simultaneous guided bone regeneration, showed less vertical bone loss, and more favorable clinical and radiographic outcomes, compared to non-augmented dehiscence defects during initial healing. At healthy single implant sites, probing depths, bleeding and plaque scores, and interproximal bone levels evaluated at 1 year, remained stable for up to 5 years, with or without STA. When single implant sites were augmented with connective tissue grafts, either for soft tissue phenotype modification or buccal soft tissue dehiscence, stable levels of the soft tissue margin, and stable or even increased soft tissue thickness and/or width of keratinized mucosa could be observed from 1 to 5 years. In contrast, non-augmented sites were more prone to show apical migration of the soft tissue margin in the long-term. Favorable aesthetic and patient-reported outcomes after STA were documented to be stable from 1 to 5 years.Results: Dimensional changes of the alveolar ridge occurred after implant placement in healed sites, and a reduction in buccal bone wall thickness (BBW) of 0.3 to 1.8 mm was observed. In healed sites with a BBW of <1.5 mm after implant placement, increased vertical bone loss, and less favorable clinical and radiographic outcomes were demonstrated. Implants with buccal dehiscence defects undergoing simultaneous guided bone regeneration, showed less vertical bone loss, and more favorable clinical and radiographic outcomes, compared to non-augmented dehiscence defects during initial healing. At healthy single implant sites, probing depths, bleeding and plaque scores, and interproximal bone levels evaluated at 1 year, remained stable for up to 5 years, with or without STA. When single implant sites were augmented with connective tissue grafts, either for soft tissue phenotype modification or buccal soft tissue dehiscence, stable levels of the soft tissue margin, and stable or even increased soft tissue thickness and/or width of keratinized mucosa could be observed from 1 to 5 years. In contrast, non-augmented sites were more prone to show apical migration of the soft tissue margin in the long-term. Favorable aesthetic and patient-reported outcomes after STA were documented to be stable from 1 to 5 years. Conclusions: It is concluded that dimensional changes of the alveolar ridge occur after implant placement in healed sites and that sites with a thin BBW after implant placement are prone to exhibit less favorable clinical and radiographic outcomes. In addition, it is concluded that STA can provide stable clinical, radiographic, aesthetic, and patient-reported outcomes in the medium and long-term.
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| 2. |
- Asa'ad, Farah, 1983, et al.
(författare)
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Role of epigenetics in alveolar bone resorption and regeneration around periodontal and peri-implant tissues.
- 2019
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Ingår i: European journal of oral sciences. - : Wiley. - 1600-0722 .- 0909-8836. ; 127:6, s. 477-493
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Tidskriftsartikel (refereegranskat)abstract
- Periodontitis and peri-implantitis are multifactorial diseases characterized by alveolar bone destruction mediated by the host response to a microbial challenge. Alveolar bone resorption mediated by epigenetics could be one of the mechanismsresponsible for this destruction of alveolar bone. The relationship between epigenetic modifications and bone metabolism has been thoroughly investigated in bone remodeling, cancer, and rheumatoid arthritis, but evidence is low regarding the relationship between epigenetic modifications and alveolar bone loss related to periodontal and peri-implant diseases. Therefore, we conducted a review of the pertinent literature based on a priori-formulated focused questions and ascreening strategy, in an attempt to comprehend the role of different epigenetic mechanisms in alveolar bone loss and to determine the current state with respect to their possible therapeutic applications in regenerative medicine. The review showed that the roles of DNA methylation, histone modifications, and non-coding RNAs in bone loss have been investigated. The results indicate that epigenetic mechanisms can participate in periodontal and peri-implant alveolar bone breakdown, suggesting their potential as therapeutic targets in alveolar bone regeneration. However, there is still only preliminary information regarding the possible therapeutic utility of these epigenetic mechanisms, suggesting a need for basic and translational research to assess the potential of such mechanisms in promoting alveolar bone regeneration.
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| 3. |
- Asa'ad, Farah, 1983, et al.
(författare)
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Scaffolds for periodontal tissue engineering
- 2019
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Ingår i: Handbook of Tissue Engineering Scaffolds: Volume One 1st Edition. - Cambridge, UK : Elsevier. - 9780081025642 ; , s. 479-496
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Bokkapitel (refereegranskat)
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| 4. |
- Buser, Daniel, et al.
(författare)
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Guided bone regeneration in implant dentistry: Basic principle, progress over 35 years, and recent research activities
- 2023
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Ingår i: Periodontology 2000. - 0906-6713 .- 1600-0757. ; 93:1, s. 9-25
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Forskningsöversikt (refereegranskat)abstract
- Bone augmentation procedures are frequent today in implant patients, since an implant should be circumferentially anchored in bone at completion of bone healing to have a good long-term stability. The best documented surgical technique to achieve this goal is guided bone regeneration (GBR) utilizing barrier membranes in combination with bone fillers. This clinical review paper reflects 35 years of development and progress with GBR. In the 1990s, GBR was developed by defining the indications for GBR, examining various barrier membranes, bone grafts, and bone substitutes. Complications were identified and reduced by modifications of the surgical technique. Today, the selection criteria for various surgical approaches are much better understood, in particular, in post-extraction implant placement. In the majority of patients, biodegradable collagen membranes are used, mainly for horizontal bone augmentation, whereas bioinert PTFE membranes are preferred for vertical ridge augmentation. The leading surgeons are using a composite graft with autogenous bone chips to accelerate bone formation, in combination with a low-substitution bone filer to better maintain the augmented bone volume over time. In addition, major efforts have been made since the millenium change to reduce surgical trauma and patient morbidity as much as possible. At the end, some open questions related to GBR are discussed.
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| 5. |
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| 6. |
- Monje, Alberto, et al.
(författare)
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Strategies for implant surface decontamination in peri-implantitis therapy
- 2022
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Ingår i: International journal of oral implantology. - : QUINTESSENCE PUBLISHING CO INC. - 2631-6420 .- 2631-6439. ; 15:3, s. 213-249
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Forskningsöversikt (refereegranskat)abstract
- Peri-implantitis is an infectious disease that leads to progressive bone loss. Surgical therapy has been advocated as a way of halting its progression and re-establishing peri-implant health. One of the most challenging but crucial tasks in the management of peri-implantitis is biofilm removal to achieve reosseointegration and promote the reduction of peri-implant pockets. A wide var-iety of strategies have been used for implant surface decontamination. Mechanical means have been demonstrated to be effective in eliminating calculus deposits and residual debris; however, the presence of undercuts and the grooves and porosities along the roughened implant surface make it difficult to achieve an aseptic surface. In conjunction with mechanical measures, use of chemical adjuncts has been advocated to dilute bacterial concentrations, destroy the bacteria's organic components and eliminate endotoxins. Pharmacological adjuncts have also been recommended to diminish the bacterial load. Other strategies, such as use of lasers, implantoplasty and electrolysis, have been suggested for implant surface decontamination to promote predictable clinical and radiographic outcomes.
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| 7. |
- Monje Real, Alberto, et al.
(författare)
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Holey Glide-Symmetric Filters for 5G at Millimeter-Wave Frequencies
- 2020
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Ingår i: IEEE Microwave and Wireless Components Letters. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1531-1309 .- 1558-1764. ; 30:1, s. 31-34
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Tidskriftsartikel (refereegranskat)abstract
- A fully metallic glide-symmetric waveguide filter with transmission in Ka -band and attenuation at its second harmonic is proposed. The filter is low-loss and cost-effective for high frequencies, and it can be easily integrated with an antenna. Glide symmetry and the possibility of breaking this symmetry provide an additional degree of freedom for passband and stopband control. A new kind of 2-D glide symmetry, referred to as braided glide symmetry, is presented, showing an increased attenuation per unit cell
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| 8. |
- Monje Real, Alberto, et al.
(författare)
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Holey Glide-Symmetric Waveguide Filters for 5G Communication Systems at Millimetre Wave Frequencies
- 2020
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Ingår i: 2020 14TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION (EUCAP 2020). - : Institute of Electrical and Electronics Engineers (IEEE).
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Konferensbidrag (refereegranskat)abstract
- In this paper, we present a holey, fully-metallic, glide symmetric waveguide filter. This solution is low-loss, cost-effective, robust and suitable for applications at millimetre wave frequencies (e.g. Ka band). We also explore here the possibility to break the glide symmetry as an additional degree of freedom to control the pass and stopbands. Finally, a denser kind of glide symmetry, named braided glide symmetry, is introduced to enhance the attenuation per unit cell.
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