| 1. |
- Balling, Gitte, et al.
(författare)
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E-bogen. Skandinaviske perspektiver på forskning og uddannelse
- 2014
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Ingår i: Nordisk Tidsskrift for informations- og kulturformidling. - : Det Informationsvidenskablige Akademi, Köbenhavns Universitet. - 2245-2931 .- 2245-294X. ; 3:1, s. 5-19
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: De skandinaviske lande har endnu ikke oplevet den samme udbredelse af e-bogen og påvirkning af bogmarkedet som det er tilfældet i de engelsksprogede lande. Alligevel er der en voksende interesse i e-bøger, ikke mindst i forsknings- og folkebibliotekerne. Denne artikel giver en oversigt over tre skandinaviske biblioteks- og informationsvidenskabelige skoler og deres forskning og undervisning i e-bøger. De respektive institutioner præsenterer deres aktuelle forskningsinteresser og -perspektiver på e-bøger og digital læsning, og hvorledes e-bøger er integreret i curriculum og uddannelser. Artiklen ender med at fremhæve fire områder, som artiklens forfattere mener, kalder på yderligere forskning inden for bibliotek- og informationsvidenskab:•Deep reading og læseoplevelser på digitale læseenheder • Den fysiske bogkulturs betydning for læsere • Aftalegrundlaget for udlån af e-bøger og ophavsret i biblioteker • E-bogens integration med andre teknologier
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| 2. |
- Balliu, Aleksandra, et al.
(författare)
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Exploring Non-obvious Hydrophobic Binding Pockets on Protein Surfaces : Increasing Affinities in Peptide–Protein Interactions
- 2017
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Ingår i: ChemBioChem. - : Wiley. - 1439-4227 .- 1439-7633. ; 18:14, s. 1396-1407
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Tidskriftsartikel (refereegranskat)abstract
- A 42-residue polypeptide conjugated to a small-molecule organic ligand capable of targeting the phosphorylated side chain of Ser15 was shown to bind glycogen phosphorylase a (GPa) with a KD value of 280 nm. The replacement of hydrophobic amino acids by Ala reduced affinities, whereas the incorporation of l-2-aminooctanoic acid (Aoc) increased them. Replacing Nle5, Ile9 and Leu12 by Aoc reduced the KD value from 280 to 27 nm. “Downsizing” the 42-mer to an undecamer gave rise to an affinity for GPa an order of magnitude lower, but the undecamer in which Nle5, Ile9 and Leu12 were replaced by Aoc showed a KD value of 550 nm, comparable with that of the parent 42-mer. The use of Aoc residues offers a convenient route to increased affinity in protein recognition as well as a strategy for the “downsizing” of peptides essentially without loss of affinity. The results show that hydrophobic binding sites can be found on protein surfaces by comparing the affinities of polypeptide conjugates in which Aoc residues replace Nle, Ile, Leu or Phe with those of their unmodified counterparts. Polypeptide conjugates thus provide valuable opportunities for the optimization of peptides and small organic compounds in biotechnology and biomedicine.
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| 3. |
- Baudoin, Eric, et al.
(författare)
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Comparison of LES Models Applied to a Bluff Body Stabilized Flame
- 2009
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Ingår i: Conference Proceeding Series, Digital.
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Konferensbidrag (refereegranskat)abstract
- Present-day demands on combustion equipment are increasing the need for improved understanding and prediction of turbulent combustion. Large Eddy Simulation (LES), in which the large-scale flow is resolved on the grid, leaving only the small-scale flow to be modeled, provides a natural framework for combustion calculations as the transient nature of the flow is resolved. In most situations, however, the flame is thinner than the LES grid, and subgrid modeling is required to handle the turbulence-chemistry interaction. Here, we examine the predictive capabilities and the theoretical links between LES flamelet models, such as the G-equation model (G-LES), and LES finite rate chemistry models, such as the Thickened Flame Model (TFM-LES), the Partially Stirred Reactor model (PaSR-LES), the Eddy Dissipation Concept (EDC-LES) model, a Presumed Probability Density Function (PPDF-LES) model and the Implicit LES (QL-LES) model. The models are described, and theoretical links between these are discussed in terms of the turbulent flame speed and flame thickness. In addition, the different models are used to study a bluff-body stabilized flame and the resulting predictions are compared with experimental data for two operating conditions.
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| 4. |
- Baudoin, Eric, et al.
(författare)
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Effect of partial premixing on stabilization and local extinction of turbulent methane/air flames
- 2011
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Ingår i: Proceedings of the 17th Mediterranean Combustion symposium, MCS 7. - 9788888104126
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Konferensbidrag (refereegranskat)abstract
- The stabilization characteristics and local extinction structures of partially premixed methane/air flames were studied using simultaneous OH-PLIF/PIV techniques, and large eddy simulations employing a two-scalar flamelet model. Partial premixing was made in a mixing chamber comprised of two concentric tubes, where the degree of partial premixing of fuel and air was controlled by varying the mixing length of the chamber. At the exit of the mixing chamber a cone was mounted to stabilize the flames at high turbulence intensities. The stability regime of flames was determined for different degree of partial premixing and Reynolds numbers. It was found that in general partially premixed flames at low Reynolds numbers become more stable when the level of partial premixing of air to the fuel stream decreases. At high Reynolds numbers, for the presently studied burner configuration there is an optimal partial premixing level of air to the fuel stream at which the flame is most stable. OH-PLIF images revealed that for the stable flames not very close to the blowout regime,significant local extinction holes appear already. By increasing premixing air to fuel stream successively, local extinction holes grow in size leading to eventual flame blowout. Local flame extinction was found to frequently attain to locations where locally high velocity flows impinging to the flame. The local flame extinction poses a future challenge for model simulations and the present flames provide a possible test case for such study.
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| 5. |
- Baudoin, Eric
(författare)
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Large Eddy Simulation of Turbulent Premixed and Partially Premixed Combustion
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this thesis, a computational fluid dynamics (CFD) approach is used to study turbulent premixed and partially premixed combustion. The CFD approach is based on large eddy simulation (LES) in which the large-scale structures of the flow are resolved on a grid, leaving only the small-scale structures (subgrid scales) to be modeled. The combustion modelling is based on the flamelet concept in which the scale separation of the flow and the chemistry is assumed. This thesis work is made up of the following parts. First, focusing on the turbulent premixed combustion, the level-set G-equation flamelet model is applied to study high density ratio flames without explicit filter in order to capture the effect of thin reaction zone embedded in the LES subgrid. Conventional fractional step methods are shown to be numerically instable for high density ratio flames. A highly robust numerical method, which is known as the ghost fluid method (GFM), is implemented. The G-equation based flamelet model and the ghost fluid method are evaluated on a lean propane/air premixed flame stabilized by a bluff body. The methods are shown to be able to capture the density ratio effect on the flame dynamics, including the near flame holder wrinkling due to Kelvin Helmholtz (KH) instabilities, the downstream large scale wrinkling due to the lower frequency Bénard/von-Karman (BVK) instability at low density ratio conditions, and the suppression of BVK instability at high density ratio conditions. In LES, spatial filtering of the reaction zone leads to thickening of the reaction zone. It is shown that thickening of the reaction zone can lead to significant under-prediction of the turbulence intensity at high density ratio conditions. The effects of flame thickening are further studied for the cases of the flame/vortex interaction and hydrodynamic instability. Essentially, with thickening of the reaction zones, the development of flame wrinkling and hydrodynamic instability are suppressed. Second, focusing on the partially premixed combustion, a two-scalar flamelet approach for LES is developed. In this approach, the trailing edge of the flame is assumed to be controlled by diffusion of mass and heat and thereby it is modelled using a steady diffusion flamelet model. The stabilization of the flame is due to the propagation of the leading premixed flame front (triple flame) in turbulent flows. The leading premixed flame is modelled using the level-set G-equation. This model is applied to simulate partially premixed flames of various fuels in a conical burner to understand the structure and the dynamics of the turbulent partially premixed flames operating in the flamelet regime and in certain cases with thicker reaction zones and local flame extinction. It is found that in general partially premixed flames are more stable when the level of partial premixing of air to the fuel stream decreases. However, at high Reynolds number conditions, an optimal level of partial premixing is found where the flame is most stable. There are two possible flammable surfaces in the partially premixed flames in the conical burner, where the mixture is in stoichiometric condition. At low Reynolds number flows, the inner flame is observed experimentally whereas it is not possible to stabilize at high Reynolds number flows. Numerical results based on the two-scalar flamelet model correctly predicted the blowoff of the inner flame at high Reynolds number conditions. It is well known that LES results are sensitive to the inflow conditions. The sensitivity of LES results to inflow turbulence and the mean flow profiles is systematically investigated based on the conical burner. It is shown that in the proximity of the burner the onset of the flow instability is not only dependent on the shape of the mean profiles, but also on the anisotropy of the inflow turbulence and the integral length scale of the inflow turbulence. This calls for special care in validation of LES models and more detailed experimental data for the inflow conditions when preparing for the database for model development and validation.
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| 6. |
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| 7. |
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| 8. |
- Baudoin, Y., et al.
(författare)
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View-finder : Robotics assistance to fire-fighting services and crisis management
- 2009
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Ingår i: Safety, Security & Rescue Robotics (SSRR), 2009 IEEE International Workshop on. - 9781424456291 ; , s. 1-6
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Konferensbidrag (refereegranskat)abstract
- In the event of an emergency due to a fire or other crisis, a necessary but time consuming pre-requisite, that could delay the real rescue operation, is to establish whether the ground or area can be entered safely by human emergency workers. The objective of the VIEW-FINDER project is to develop robots which have the primary task of gathering data. The robots are equipped with sensors that detect the presence of chemicals and, in parallel, image data is collected and forwarded to an advanced Control station (COC). The robots will be equipped with a wide array of chemical sensors, on-board cameras, Laser and other sensors to enhance scene understanding and reconstruction. At the Base Station (BS) the data is processed and combined with geographical information originating from a web of sources; thus providing the personnel leading the operation with in-situ processed data that can improve decision making. This paper will focus on the Crisis Management Information System that has been developed for improving a Disaster Management Action Plan and for linking the Control Station with a out-site Crisis Management Centre, and on the software tools implemented on the mobile robot gathering data in the outdoor area of the crisis.
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| 9. |
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| 10. |
- Borg, Markus, et al.
(författare)
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Analyzing Networks of Issue Reports
- 2013
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Ingår i: [Host publication title missing]. - 1944-2793 .- 1534-5351. ; , s. 79-88
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Konferensbidrag (refereegranskat)abstract
- Completely analyzed and closed issue reports in software development projects, particularly in the development of safety-critical systems, often carry important information about issue-related change locations. These locations may be in the source code, as well as traces to test cases affected by the issue, and related design and requirements documents. In order to help developers analyze new issues, knowledge about issue clones and duplicates, as well as other relations between the new issue and existing issue reports would be useful. This paper analyses, in an exploratory study, issue reports contained in two Issue Management Systems (IMS) containing approximately 20.000 issue reports. The purpose of the analysis is to gain a better understanding of relationships between issue reports in IMSs. We found that link-mining explicit references can reveal complex networks of issue reports. Furthermore, we found that textual similarity analysis might have the potential to complement the explicitly signaled links by recommending additional relations. In line with work in other fields, links between software artifacts have a potential to improve search and navigation in large software engineering projects.
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